Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Michael Caffrey"'
Autor:
Michael Caffrey, Nitin Jayakumar, Veronique Caffrey, Varada Anirudhan, Lijun Rong, Igor Paprotny
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT The recent COVID-19 pandemic has underscored the danger of airborne viral pathogens. The lack of model systems to study airborne pathogens limits the understanding of airborne pathogen distribution as well as potential surveillance and mitig
Externí odkaz:
https://doaj.org/article/faa1d1f5818e4ad6a546e1ebd40135b0
Autor:
Michael Caffrey, Arnon Lavie
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Influenza hemagglutinin (HA) is a viral membrane bound protein that plays a critical role in the viral life cycle by mediating entry into target cells. HA exploits the lowering of the pH in the endosomal compartment to initiate a series of conformati
Externí odkaz:
https://doaj.org/article/a2defce49ed0421694a5d313c29ac94a
Autor:
Adam Schafer, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E Ramirez, Norton P Peet, Michael Caffrey, Gregory R J Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009312 (2021)
Many small molecules have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these molecules limits further their development as anti-filoviral agents. Here we provide evidence that tor
Externí odkaz:
https://doaj.org/article/513584dcab26402ea212101359422d10
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 587 (2021)
Hemagglutinin (HA) plays a critical role during influenza virus receptor binding and subsequent membrane fusion process, thus HA has become a promising drug target. For the past several decades, we and other researchers have discovered a series of HA
Externí odkaz:
https://doaj.org/article/2b07a42cd1f04e549cc9443705fb5b50
Autor:
Kiira Ratia, Samuel H Light, Aleksandar Antanasijevic, Wayne F Anderson, Michael Caffrey, Arnon Lavie
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89356 (2014)
A vibrant and healthy gut flora is essential for preventing the proliferation of Clostridium difficile, a pathogenic bacterium that causes severe gastrointestinal symptoms. In fact, most C. difficile infections (CDIs) occur after broad-spectrum antib
Externí odkaz:
https://doaj.org/article/9c5dcf45f6e44ba8b49617f278a29cd1
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76363 (2013)
The recent outbreak of H7N9 influenza in China is of high concern to public health. H7 hemagglutinin (HA) plays a critical role in influenza entry and thus HA presents an attractive target for antivirals. Previous studies have suggested that the smal
Externí odkaz:
https://doaj.org/article/5632306ec7944481a40b1805a19fd9ce
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e33958 (2012)
In influenza, the envelope protein hemagglutinin (HA) plays a critical role in viral entry by first binding to sialic acid receptors on the cell surface and subsequently mediating fusion of the viral and target membranes. In this work, the receptor b
Externí odkaz:
https://doaj.org/article/49e983819f4947babd9b41db7dfe7a09
Autor:
Arnon Lavie, Pieter Van Vlierberghe, Yogen Saunthararajah, Bradley J. Merrill, Alexander V. Lyubimov, Kasim K. Kabirov, Michael J. Schlicht, Steven Goossens, Barbara De Moerloose, Veerle Mondelaers, Tim Lammens, Sofie Peirs, Andre Kajdacsy-Balla, Maarten C. Bosland, Dolores L. Mahmud, Annie Oh, Damiano Rondelli, Li Liu, Amanda M. Schalk, Michael Caffrey, Aleksandar Antanasijevic, Jenny Y. Zhang, Ying Su, Hien Anh Nguyen
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug l-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine dependency of ALL ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ce5dcf2ef313cf6c08af831f69df03
https://doi.org/10.1158/0008-5472.c.6509787
https://doi.org/10.1158/0008-5472.c.6509787
Autor:
August Gula, Daniel Arnold, Jonathan Barney, Kerry Boyd, Michael Caffrey, Michael Holloway, Martin Kroupa, Brian A. Larsen, Carlos A. Maldonado, Susan Mendel, Zachary Miller, Rachel Simms
Publikováno v:
2023 IEEE Aerospace Conference.
Autor:
Carlos A. Maldonado, Jonathan Deming, Brooke N. Mosley, Justin McGlown, Anthony Nelson, Phil A. Fernandes, Anthony J. Rogers, Douglas Patrick, Martin Kroupa, Michael Caffrey, Susan Mendel, Kerry Boyd, August Gula, Kim Katko, Markus P. Hehlen, Daniel Arnold, Jonathan Barney, Ted Schultz, Dan Reisenfeld, Ruth Skoug, Angus Guider, Michael Holloway, Heidi Morning, John T. Steinberg, Erik Krause, Andrew Kirby, Darrel Beckman, Justin Tripp, Keith S. Morgan, Zachary Miller, Rob Merl, Paul S. Graham, Bradley Hoose, Joshua Ortner, Quinn Cole, Chuck Clanton, Brian A. Larsen, Tom Fairbanks, Jeff George, Rory Scobie, Kasidit Subsomboon, Kristina McKeown, Katherine Alano, John Michel
Publikováno v:
2023 IEEE Aerospace Conference.