Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Michael C. Venuti"'
Autor:
Peppi Prasit, James T. Palmer, Robert G. Strickley, M. David Percival, Liang Liu, Dan-Xiong Wang, Rohan Mendonca, Donald B. Kimmel, Leland C. Ii Burrill, Oballa Renata Marcella, Denis Riendeau, Colena Johnson, Tobee Chung, Young Robert N, Mary E. McGrath, John McCarter, Gregg Wesolowski, Michael C. Venuti, Eric B. Springman, Sevgi B. Rodan, Robert M. Rydzewski, James W. Janc, Bryant Clifford M, Z. Walter Yu, Harry Cheung, Eduardo L. Setti, Tian Zong-Qiang, Dana E. Davis, Jean-Pierre Falgueyret, Philip Enriquez, John R. Somoza, Gideon A. Rodan, Shankar Venkatraman
Publikováno v:
Journal of Medicinal Chemistry. 48:7520-7534
We have prepared a series of achiral aminoacetonitriles, bearing tri-ring benzamide moieties and an aminocyclohexanecarboxylate residue at P2. This combination of binding elements resulted in sub-250 pM, reversible, selective, and orally bioavailable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162e31c572aa51cc7d9a1b06687fc694
https://doi.org/10.1021/jm058198r
https://doi.org/10.1021/jm058198r
Autor:
Steven M. Chamow, Timothy P. Kogan, David H. Peers, Michael C. Venuti, Reed J. Harris, Joyce Mordenti, Steven Shak, Thomas Gadek, Avi Ashkenazi
Publikováno v:
Bioconjugate Chemistry. 5:133-140
CD4 immunoadhesin (CD4-IgG) is a chimeric glycoprotein molecule comprised of the gp120-binding portion of human CD4 fused to the hinge and Fc portions of human IgG. As a candidate for human therapeutic use, CD4-IgG represents an important advance ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642304d37eccf9d6dd02cf6e971f17b
https://doi.org/10.1021/bc00026a005
https://doi.org/10.1021/bc00026a005
Autor:
Thomas R. Gadek, Rob Webb, Mark Reynolds, Todd C. Somers, Thomas E. Rawson, Robert S. McDowell, Maureen H. Tischler, Eugene D. Thorsett, Lawrence Mcgee, Michael C. Venuti, Kirk Robarge, Brent Blackburn
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::964bdbc9d9745e58a64143fa2eee280f
https://doi.org/10.1002/chin.199447184
https://doi.org/10.1002/chin.199447184
Autor:
Michael C. Venuti, Rob Webb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:457-460
The synthesis of 5,6-substituted teleocidin analogue 3 is reported. Reduction of oxime 7 (obtained from indole 6 ) gave diastereomeric amines 8 and 9 which were cyclized to give esters 10 and 11 , respectively. Reduction of 10 yielded teleocidin anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96d0c36925856a1a1070f919b1bd6aa
https://doi.org/10.1016/s0960-894x(00)80169-9
https://doi.org/10.1016/s0960-894x(00)80169-9
Publikováno v:
The Journal of Organic Chemistry. 56:4706-4713
A simplified tetramethyl analogue 3 of Teleocidin B-4 (1) has been synthesized from dinitrotoluene 6 via indole 4. The valine moiety of analogue 3 was provided by the coupling of (N-methylamino)indole 16 derived from 4 with the triflate of (R)-2-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8767e91636d20f675d978d246ce212ee
https://doi.org/10.1021/jo00015a026
https://doi.org/10.1021/jo00015a026
Publikováno v:
Tetrahedron. 46:6623-6632
(-)-Indolactam-V (IL-V) ( 1 ) -was prepared in 10 steps from L-tryptophan methyl ester in 17.1% overall yield. The key steps involve regiospecific thallation of the acylindole intermediate ( 4 ), followed by azide displacement and reduction to introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d454469c4cb4fd387d470b15e59734c4
https://doi.org/10.1016/s0040-4020(01)87853-4
https://doi.org/10.1016/s0040-4020(01)87853-4
Autor:
Nathalie Chauret, Robert Zamboni, Denis Riendeau, Sevgi B. Rodan, Joel Robichaud, Gideon A. Rodan, Michel Therien, Sylvie Desmarais, Michael C. Venuti, W. Cameron Black, Tammy LeRiche, Donald B. Kimmel, Chun Sing Li, Daniel J. McKay, Gregg Wesolowski, Robert N. Young, Le T. Duong, Sonia Lamontagne, M. David Percival, Serge Leger, Jean-Pierre Falgueyret, Wanda Cromlish, Deborah A. Nicoll-Griffith, Frédéric Massé, Renata Oballa, James T. Palmer, Vouy-Linh Truong, Carmai Seto, Jacques Yves Gauthier
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(3)
Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to address the metabolic liabilities of the Cat K inhibitor L-873724. Substituting P1 and modifying the P2 side chain led to a metabolically robust inhibitor wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03360c5f33ba76a597de35d2b38012a
https://pubmed.ncbi.nlm.nih.gov/18226527
https://pubmed.ncbi.nlm.nih.gov/18226527
Autor:
Michael C. Venuti
Publisher Summary The evolution of recombinant DNA technology, from scientific innovation to pharmaceutical discovery process, has occurred in parallel with the development of contemporary medicinal chemistry. The products of biotechnology research,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f36d8fe12de3254a1cc19cf04a53c3
https://doi.org/10.1016/s0065-7743(08)61607-3
https://doi.org/10.1016/s0065-7743(08)61607-3
Autor:
Joseph M. Muchowski, Michael C. Venuti
Publikováno v:
The Journal of Organic Chemistry. 45:4798-4801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b47dfcd4bc796d9c55558c0d189089e4
https://doi.org/10.1021/jo01311a059
https://doi.org/10.1021/jo01311a059