Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael C. Regan"'
Autor:
Nami Tajima, Noriko Simorowski, Remy A. Yovanno, Michael C. Regan, Kevin Michalski, Ricardo Gómez, Albert Y. Lau, Hiro Furukawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders. Here, the authors report identification of a functional antibody that specifically targets and alloster
Externí odkaz:
https://doaj.org/article/1cf9e3b9914747658d1ba71b8d1cc3e8
Autor:
Michael C. Regan, Zongjian Zhu, Hongjie Yuan, Scott J. Myers, Dave S. Menaldino, Yesim A. Tahirovic, Dennis C. Liotta, Stephen F. Traynelis, Hiro Furukawa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Context-dependent inhibition of NMDA receptors has important therapeutic implications for treatment of neurological diseases. Here, the authors use structural biology and biophysics to describe the basis for pH-dependent inhibition for a class of all
Externí odkaz:
https://doaj.org/article/6b226358d0264cea8bca51d4ed185d0d
Autor:
Lynnea D. Harris, Michael C. Regan, Scott J. Myers, Kelsey A. Nocilla, Nicholas S. Akins, Yesim A. Tahirovic, Lawrence J. Wilson, Ray Dingledine, Hiro Furukawa, Stephen F. Traynelis, Dennis C. Liotta
Publikováno v:
ACS Chemical Neuroscience. 14:917-935
Autor:
Lonnie P. Wollmuth, Mark E. Bowen, Catherine L. Salussolia, Hiro Furukawa, Michael C. Regan, Jian Dai, Johansen B. Amin, Kelvin Chan, Huan-Xiang Zhou
Publikováno v:
The Journal of General Physiology
AMPA and NMDA receptors are ionotropic glutamate receptors that make fundamental contributions to synaptic activity in the brain in different ways. Amin et al. show that their respective M4 segments, located on the periphery of their pore domains, co
Autor:
Michael C. Regan, Miranda J. McDaniel, Jing Zhang, Stephen F. Traynelis, Tim Grant, Erkan Karakas, Nikolaus Grigorieff, Hiro Furukawa
Publikováno v:
Neuron. 98(3)
Alternative gene splicing gives rise to N-methyl-D-aspartate (NMDA) receptor ion channels with defined functional properties and unique contributions to calcium signaling in a given chemical environment in the mammalian brain. Splice variants possess
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 4, p e1007374 (2018)
PLoS Genetics, Vol 14, Iss 4, p e1007374 (2018)
Plant shoot systems derive from the shoot apical meristems (SAMs), pools of stems cells that are regulated by a feedback between the WUSCHEL (WUS) homeobox protein and CLAVATA (CLV) peptides and receptors. The maize heterotrimeric G protein α subuni
Autor:
Michael C. Regan, Hiro Furukawa
Publikováno v:
Neuron. 91:1187-1189
Two articles in this issue of Neuron (Yelshanskaya et al., 2016; Yi et al., 2016) explore the structural basis of allosteric inhibition in ionotropic glutamate receptors, providing key insights into how iGluRs function in the brain as well as how the
Autor:
Jeffrey N. Savas, Joris de Wit, Jo Begbie, Christina Heroven, Alexandra C. Smith, Jonathan Elegheert, Vedrana Cvetkovska, Hiro Furukawa, Michael C. Regan, Wanyi Jia, Amber J. Clayton, Samuel N. Smukowski, A. Radu Aricescu, Ann Marie Craig, Kristel M. Vennekens
Publikováno v:
Neuron
'Neuron ', vol: 95, pages: 896-913 (2017)
'Neuron ', vol: 95, pages: 896-913 (2017)
Summary Neuroligin-neurexin (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system. An accurate spatial and temporal control of NL-NRX signaling is crucial to balance excitatory and inhibitory neurotransmission, and pert
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles
Autor:
Caroline L. Speck, Nancy A. Speck, Maren E. Speck, Michael C. Regan, Yunpeng Zhou, Stephen M Griffey, Patrick R. Cushing, Ting Lei Gu, Liya Roudaia, John H. Bushweller, Christina J. Matheny, Takeshi Corpora, Miki Newman
Publikováno v:
The EMBO Journal. 26:1163-1175
Monoallelic RUNX1 mutations cause familial platelet disorder with predisposition for acute myelogenous leukemia (FPD/AML). Sporadic mono- and biallelic mutations are found at high frequencies in AML M0, in radiation-associated and therapy-related mye
N-methyl-d-aspartate receptors (NMDARs) belong to the large family of ionotropic glutamate receptors (iGluRs), which are critically involved in basic brain functions as well as multiple neurological diseases and disorders. The NMDARs are large hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7c254f9afb422d5a9c92103ab0c71d
https://europepmc.org/articles/PMC4641752/
https://europepmc.org/articles/PMC4641752/