Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Michael C. Phillips"'
Autor:
Eleonora Scorletti, Yedidya Saiman, Sookyoung Jeon, Carolin V. Schneider, Delfin G. Buyco, Chelsea Lin, Blanca E. Himes, Clementina A. Mesaros, Marijana Vujkovic, Kate Townsend Creasy, Emma E. Furth, Jeffrey T. Billheimer, Nicholas J. Hand, David E. Kaplan, Kyong-Mi Chang, Philip S. Tsao, Julie A. Lynch, Joseph L. Dempsey, Julia Harkin, Susovon Bayen, Donna Conlon, Marie Guerraty, Michael C. Phillips, Daniel J. Rader, Rotonya M. Carr
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100902- (2024)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of lipid droplets (LDs) within hepatocytes. Perilipin 2 (PLIN2) is the most abundant protein in hepatic LDs and its expression correlates with intracell
Externí odkaz:
https://doaj.org/article/0f2aac76aa174d06be32dcaf8efba46a
Autor:
Nicholas N. Lyssenko, Naqi Haider, Antonino Picataggi, Eleonora Cipollari, Wanzhen Jiao, Michael C. Phillips, Daniel J. Rader, Venkata Ramana Murthy Chavali
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 10, Pp 1927-1939 (2018)
Cholesterol-containing soft drusen and subretinal drusenoid deposits (SDDs) occur at the basolateral and apical side of the retinal pigment epithelium (RPE), respectively, in the chorioretina and are independent risk factors for late age-related macu
Externí odkaz:
https://doaj.org/article/82a8bc931c4a4aeab831b0af8eef13b0
Autor:
Michael C. Phillips
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 749-763 (2018)
ABCA1 functions as a lipid transporter because it mediates the transfer of cellular phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins present in the extracellular medium. ABCA1 is a membrane PL translocase and
Externí odkaz:
https://doaj.org/article/371ecd1991714b9787f30ebaeb32f0b2
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 447-449 (2019)
Externí odkaz:
https://doaj.org/article/691d19400ba346918ced5cb19709ff15
Autor:
Xin Bi, Evanthia E. Pashos, Marina Cuchel, Nicholas N. Lyssenko, Mayda Hernandez, Antonino Picataggi, James McParland, Wenli Yang, Ying Liu, Ruilan Yan, Christopher Yu, Stephanie L. DerOhannessian, Michael C. Phillips, Edward E. Morrisey, Stephen A. Duncan, Daniel J. Rader
Publikováno v:
EBioMedicine, Vol 18, Iss C, Pp 139-145 (2017)
Despite the recognized role of the ATP-binding Cassette Transporter A1 (ABCA1) in high-density lipoprotein (HDL) metabolism, our understanding of ABCA1 deficiency in human hepatocytes is limited. To define the functional effects of human hepatocyte A
Externí odkaz:
https://doaj.org/article/946ab8b7ea644fcfaed179b2dcca84c0
Autor:
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 5, Pp 972-985 (2015)
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic stra
Externí odkaz:
https://doaj.org/article/cbf0a92bb5874c11a69dc96e5efce1af
Autor:
Eric T. Alexander, Michael C. Phillips
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 12, Pp 3464-3470 (2013)
It is important to understand HDL heterogeneity because various subspecies possess different functionalities. To understand the origins of HDL heterogeneity arising from the existence of particles containing only apoA-I (LpA-I) and particles containi
Externí odkaz:
https://doaj.org/article/27301055c8c9407eb75e8f8653ae79bc
Autor:
Michael C. Phillips
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2034-2048 (2013)
Apolipoprotein (apo)A-I is the principal protein component of HDL, and because of its conformational adaptability, it can stabilize all HDL subclasses. The amphipathic α-helix is the structural motif that enables apoA-I to achieve this functionality
Externí odkaz:
https://doaj.org/article/1adf2211ce7146e48bc80eb239cbccf9
Autor:
Palaniappan Sevugan Chetty, David Nguyen, Margaret Nickel, Sissel Lund-Katz, Leland Mayne, S.Walter Englander, Michael C. Phillips
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1589-1597 (2013)
Elucidation of apoA-I secondary structure in spherical plasma HDL particles is essential for understanding HDL structure and function at the molecular level. To provide this information, we have applied hydrogen exchange (HX) and mass spectrometry me
Externí odkaz:
https://doaj.org/article/c1819ae8aeb2452eb464c7ad4db5c4b1
Autor:
Sandhya Sankaranarayanan, Margarita de la Llera-Moya, Denise Drazul-Schrader, Michael C. Phillips, Ginny Kellner-Weibel, George H. Rothblat
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 671-676 (2013)
An important mechanism contributing to cell cholesterol efflux is aqueous transfer in which cholesterol diffuses from cells into the aqueous phase and becomes incorporated into an acceptor particle. Some compounds can enhance diffusion by acting as s
Externí odkaz:
https://doaj.org/article/222f0a636e4b4dc4829400644d8ceef5