Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael C. Paul-Smith"'
Autor:
Kamila M Pytel, Jean-François Gélinas, Deborah R. Gill, Lee A. Davies, Amit C. Nathwani, Stephen C. Hyde, Lidia Cammack, Makoto Inoue, Ian A. Pringle, Caroline Moran, Eric W.F.W. Alton, S Tsugumine, Michael C. Paul-Smith, Mario Chan, Takashi Hironaka, Loren Cameron, Cuixiang Meng, Uta Griesenbach, Jenny McIntosh, Robyn V. Bell
Publikováno v:
Gene Therapy
We have shown that a lentiviral vector (rSIV.F/HN) pseudotyped with the F and HN proteins from Sendai virus generates high levels of intracellular proteins after lung transduction. Here, we evaluate the use of rSIV.F/HN for production of secreted pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e3b640266d52e588db1236db1240c8
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Introduction: Since identification of the disease causing gene over 25 years ago, cystic fibrosis (CF) has been at the forefront of gene therapy research. Despite initial optimism, CF gene therapy has proven considerably more challenging than initial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762a211af48e785c281409a87a3d6819
http://hdl.handle.net/10044/1/32253
http://hdl.handle.net/10044/1/32253
Autor:
Deborah R. Gill, Amit C. Nathwani, Stephen C. Hyde, Uta Griesenbach, Kamila M Pytel, Cuixiang Meng, Jenny McIntosh, Lee A. Davies, Ian A. Pringle, Mario Chan, Michael C. Paul-Smith, Mamoru Hasegawa, Eric W.F.W. Alton, Makoto Inoue
Publikováno v:
Molecular Therapy. 23
We have previously shown that the lung can be used as “factory” for production of secreted proteins, which are released into the circulation, using Sendai virus-mediated gene transfer. However, gene expression was transient and repeated administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04880cd1960245d6a7c85343f70b17ec
Autor:
C Meng, Stephen C. Hyde, Ewfw Alton, Kamila M Pytel, Mamoru Hasegawa, U Griesenbach, Jean-François Gélinas, Lee A. Davies, L Cameron, L Cammack, C Moran, Mario Chan, Gill, Makoto Inoue, Michael C. Paul-Smith, Ian A. Pringle
Publikováno v:
Thorax. 70:A72-A73
Introduction and objectives A protease/anti-protease imbalance is a characteristic feature of inflammatory lung diseases such as cystic fibrosis (CF) and alpha-1-antitrypsin deficiency related emphysema. A recent trial of alpha-1-antitrypsin (hAAT) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6438d7dce82d5d18416aedb5a1696aeb
https://doi.org/10.1136/thoraxjnl-2015-207770.133
https://doi.org/10.1136/thoraxjnl-2015-207770.133
Autor:
C Moran, Ewfw Alton, S Tsugumine, T Higgins, Ian A. Pringle, U Griesenbach, Lee A. Davies, S C Hyde, Andrea Rodriguez-Martinez, Jane C. Davies, Barbara J Stevenson, Kamila M Pytel, Sabrina Gea-Sorli, Laura Hyndman, Gill, Amanda Boyd, Mamoru Hasegawa, Makoto Inoue, Johanna F. Dekkers, Heather E Davidson, G McLachlan, Michael C. Paul-Smith, C Meng, Jeffrey M. Beekman, Mario Chan
Publikováno v:
Thorax. 70:A34.2-A34
The UK CF Gene Therapy Consortium has developed a pipeline of vectors to deliver CFTR into the airway epithelium. The first of these (plasmid/liposome complexes) recently completed a Phase IIb trial. Anticipating that increased efficiency of gene tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2643fe12bff39ca5f746476e09975c
https://doi.org/10.1136/thoraxjnl-2015-207770.62
https://doi.org/10.1136/thoraxjnl-2015-207770.62
Autor:
Ian A. Pringle, Amit C. Nathwani, Gill, Jenny McIntosh, Ewfw Alton, Mario Chan, Kamila M Pytel, Michael C. Paul-Smith, Makoto Inoue, L Davis, Cuixiang Meng, Mamoru Hasegawa, Uta Griesenbach, Stephen C. Hyde
Publikováno v:
Thorax. 70:A67.1-A67
We have previously shown that lung when treated with Sendai virus-mediated gene transfer can produce secreted proteins and release them into the circulation (Griesenbach et al. , Mol Therapy 2002). Despite the high levels of transduction efficiency t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e8f6f9af6921087fdc6e00e99a35f0
https://doi.org/10.1136/thoraxjnl-2015-207770.123
https://doi.org/10.1136/thoraxjnl-2015-207770.123
Autor:
Caroline Moran, Mamoru Hasegawa, Michael C. Paul-Smith, Ian A. Pringle, Uta Griesenbach, Kamila M Pytel, Stephen C. Hyde, Cuixang Meng, Loren Cameron, Eric W.F.W. Alton, Makoto Inoue, Lee A. Davies, Deborah R. Gill, Lidia Cammack, Jean-François Gélinas, Mario Chan
Publikováno v:
Molecular Therapy. 23:S147
A protease/anti-protease imbalance is a characteristic feature of inflammatory lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). However, alpha-1-antitrypsin (AAT) enzyme replacement therapy (ERT) trials hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031b0f44d0d7a9f6070dcc761f1b1a5b
https://doi.org/10.1016/s1525-0016(16)33979-x
https://doi.org/10.1016/s1525-0016(16)33979-x