Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael C. Naski"'
Publikováno v:
Journal of Biological Chemistry. 287:21082-21092
Canonical Wnt signaling strongly inhibits chondrogenesis. Previously, we identified Twist1 as a critical downstream mediator of Wnt in repression of chondrocyte differentiation. However, the mechanistic basis for the antichondrogenic activity of Twis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dad73481f14a30212c220c317fe7b74
https://doi.org/10.1074/jbc.m111.328567
https://doi.org/10.1074/jbc.m111.328567
Autor:
Joel M. Weinberg, Michael C. Naski, Hui Geng, Guichun Wang, Jeffrey L. Barnes, Andrew Brooks, Rongpei Lan, Abdur R. Siddiqi, Manjeri A. Venkatachalam, Pothana Saikumar
Publikováno v:
The American Journal of Pathology. 174:1291-1308
We studied autocrine transforming growth factor (TGF)beta signaling in kidney epithelium. Cultured proximal tubule cells showed regulated signaling that was high during log-phase growth, low during contact-inhibited differentiation, and rapidly incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54b97c240d1522f74082193beafcad1
https://doi.org/10.2353/ajpath.2009.080295
https://doi.org/10.2353/ajpath.2009.080295
Publikováno v:
Journal of Biological Chemistry. 279:38209-38219
Fibroblast growth factors (FGFs) and bone morphogenetic proteins strongly regulate chondrogenesis and chondrocyte gene expression. The interactions of the signaling pathways initiated by these factors are central to the control of chondrocyte differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6055f73065cf508f0b6f8bd0825f7ea
https://doi.org/10.1074/jbc.m404855200
https://doi.org/10.1074/jbc.m404855200
Publikováno v:
Developmental Cell. 3:439-449
Mutations in fibroblast growth factor (FGF) receptor 3 lead to the human dwarfism syndrome achondroplasia. Using a limb culture system, we have analyzed the role of FGF signaling and its interaction with the Ihh/Pthlh and BMP pathways in regulating c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59aec0493e00e18e5fa4de9f0e18e371
https://doi.org/10.1016/s1534-5807(02)00261-7
https://doi.org/10.1016/s1534-5807(02)00261-7
Autor:
Dashen Wang, David Goltzman, Michelle M. Aarts, Michael C. Naski, Li Cheng, Janet E. Henderson, David M. Ornitz
Publikováno v:
Journal of Bone and Mineral Research. 15:155-165
A G380R substitution in the transmembrane-spanning region of FGFR3 (FGFR3Ach) results in constitutive receptor kinase activity and is the most common cause of achondroplastic dwarfism in humans. The epiphyseal growth plates of affected individuals ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea037cf2abe2f54e15f193cc4d22e97
https://doi.org/10.1359/jbmr.2000.15.1.155
https://doi.org/10.1359/jbmr.2000.15.1.155
Publikováno v:
Journal of Biological Chemistry. 274:30934-30942
Signaling through fibroblast growth factor receptors (FGFRs) is critical for the development and patterning of the vertebrate skeleton. Gain-of-function alleles of fgfr2 and fgfr3 have been linked to several dominant skeletal disorders in humans, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817eac573a74d50c2b167c60226c220a
https://doi.org/10.1074/jbc.274.43.30934
https://doi.org/10.1074/jbc.274.43.30934
Publikováno v:
Pediatric Pathology & Molecular Medicine. 18:355-379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24b174904151f4ca8ed70f08181dcd2f
https://doi.org/10.1080/152279598307921
https://doi.org/10.1080/152279598307921
Autor:
Michael C. Naski, David M. Ornitz
Publikováno v:
Frontiers in Bioscience. 3:d781-794
The fibroblast growth factor receptor family consists of four receptor tyrosine kinases which bind with varying affinity and specificity to a family of at least fifteen polypeptide ligands. The receptors and ligands perform many essential functions d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404030be0ea6b2c70a303691fd91411f
https://doi.org/10.2741/a321
https://doi.org/10.2741/a321
Publikováno v:
Nature Genetics. 13:233-237
The longitudinal growth of the skeleton arises from the continuous process of endochondral ossification occurring at the ends of growing long bones. Dwarfism results when this process is disrupted, as in the autosomal dominant human skeletal diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495a699fccec4b6c9ad679bf473a5c4d
https://doi.org/10.1038/ng0696-233
https://doi.org/10.1038/ng0696-233
During endochondral ossification, the cartilage is surrounded by a layer of cells that constitute the perichondrium. Communication between osteoblasts in the perichondrium via N-cadherin adherens junctions is essential for endochondral bone growth. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4015d9f1a4e22500fd57af6ef132510
https://europepmc.org/articles/PMC3251172/
https://europepmc.org/articles/PMC3251172/
