Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael C. Justice"'
Autor:
Fernando Pelaez, Angela Basilio, José R. Tormo, Michael C. Justice, Jennifer Nielsen Kahn, Guy H. Harris, Francisca Vicente, Jesús Martín, Antonio González del Val, Gonzalo Platas, Deborah L. Zink, Javier Collado, Gerald F. Bills
Publikováno v:
Mycological Research. 113:754-770
Sordarins are a class of natural antifungal agents which act by specifically inhibiting fungal protein synthesis through their interaction with the elongation factor 2, EF2. A number of natural sordarins produced by diverse fungi of different classes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7616041931cc38038549d5b444dd34
https://doi.org/10.1016/j.mycres.2009.02.011
https://doi.org/10.1016/j.mycres.2009.02.011
Autor:
Jonathan D. Dinman, Anne Carr-Schmid, Jason W. Harger, Mythili S. Shastry, Michael C. Justice, Terri Goss Kinzy, Jane Kwon
Publikováno v:
Virology. 300(1):60-70
Many viruses use programmed −1 ribosomal frameshifting to ensure the correct ratio of viral structural to enzymatic proteins. Alteration of frameshift efficiencies changes these ratios, in turn inhibiting viral particle assembly and virus propagati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d531384fc3bf82256649de6ca790ec
Autor:
Michael C. Justice, Karen Carniol, Jennifer Nielsen, Dennis M. Schmatz, Theresa Ku, Ming-Jo Hsu
Publikováno v:
Journal of Biological Chemistry. 274:4869-4875
The natural product sordarin, a tetracyclic diterpene glycoside, selectively inhibits fungal protein synthesis by impairing the function of eukaryotic elongation factor 2 (eEF2). Sordarin and its derivatives bind to the eEF2-ribosome-nucleotide compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903798fb3786bc18de2080c3a1b7d5a5
https://doi.org/10.1074/jbc.274.8.4869
https://doi.org/10.1074/jbc.274.8.4869
Autor:
Theresa Ku, Jennifer Nielsen, Michael C. Justice, Ming-Jo Hsu, Dennis M. Schmatz, James M. Balkovec, Bruno Tse
Publikováno v:
Journal of Biological Chemistry. 273:3148-3151
Elongation factor 2 (EF2) is an essential protein catalyzing ribosomal translocation during protein synthesis and is highly conserved in all eukaryotes. It is largely interchangeable in translation systems reconstituted from such divergent organisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aebf95a78658fedb94d6e58d1a7f3c5
https://doi.org/10.1074/jbc.273.6.3148
https://doi.org/10.1074/jbc.273.6.3148
Autor:
Michael C. Justice, Arturas Meskauskas, Jennifer Nielsen, Jonathan D. Dinman, Jason W. Harger
Publikováno v:
Virology. 286(1)
Programmed ribosomal frameshifting is utilized by a number of RNA viruses to ensure the correct ratio of viral structural to enzymatic proteins for viral particle assembly. Altering frameshifting efficiencies upsets this ratio, inhibiting virus propa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4c6eea582a344b506882057502b448
https://pubmed.ncbi.nlm.nih.gov/11448174
https://pubmed.ncbi.nlm.nih.gov/11448174
Autor:
Mythili, Shastry, Jennifer, Nielsen, Theresa, Ku, Ming-Jo, Hsu, Paul, Liberator, Jennifer, Anderson, Dennis, Schmatz, Michael C, Justice
Publikováno v:
Microbiology (Reading, England). 147(Pt 2)
The sordarin class of natural products selectively inhibits fungal protein synthesis by impairing the function of eukaryotic elongation factor 2 (eEF2). Mutations in Saccharomyces cerevisiae eEF2 or the ribosomal stalk protein rpP0 can confer resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22437198e3d6d16994ef7e119b5ca880
https://pubmed.ncbi.nlm.nih.gov/11158355
https://pubmed.ncbi.nlm.nih.gov/11158355
Publikováno v:
Nucleic acids research. 25(23)
The homeodomain (HD) is a conserved sequence-specific DNA-binding motif found in many eukaryotic transcriptional regulatory proteins. Despite the wealth of in vitro data on the mechanism HD proteins use to bind DNA, comparatively little is known abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54348649e6363bd2bcad9b0898aae1ed
https://pubmed.ncbi.nlm.nih.gov/9365251
https://pubmed.ncbi.nlm.nih.gov/9365251
Autor:
Mythili S. Shastry, A. Rod Merrill, Michael C. Justice, Rikke Søe, Gregers R. Andersen, Ralph T. Mosley, Jennifer Nielsen-Kahn
Publikováno v:
Aarhus University
Søe, R, Mosley, R T, Justice, M, Nielsen-Kahn, J, Shastry, M, Merrill, A R & Andersen, G R 2007, ' Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2 ', Journal of Biological Chemistry, vol. 282, pp. 657-666 .
Søe, R, Mosley, R T, Justice, M, Nielsen-Kahn, J, Shastry, M, Merrill, A R & Andersen, G R 2007, ' Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2 ', Journal of Biological Chemistry, vol. 282, pp. 657-666 .
The sordarins are fungal specific inhibitors of the translation factor eEF2, which catalyzes the translocation of tRNA and mRNA after peptide bond formation. We have determined the crystal structures of eEF2 in complex with two novel sordarin derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512b9ae825a41110c3ff38bb648932e3
https://pure.au.dk/portal/en/publications/sordarin-derivatives-induce-a-novel-conformation-of-the-yeast-ribosome-translocation-factor-eef2(3b962080-c88d-11db-bee9-02004c4f4f50).html
https://pure.au.dk/portal/en/publications/sordarin-derivatives-induce-a-novel-conformation-of-the-yeast-ribosome-translocation-factor-eef2(3b962080-c88d-11db-bee9-02004c4f4f50).html
