Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael C. Gutkin"'
Autor:
Pradeep Ramalingam, Michael C. Gutkin, Michael G. Poulos, Taylor Tillery, Chelsea Doughty, Agatha Winiarski, Ana G. Freire, Shahin Rafii, David Redmond, Jason M. Butler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aging associated defects within stem cell-supportive niches contribute towards age-related decline in stem cell activity. However, mechanisms underlying age-related niche defects, and whether restoring niche function can improve stem cell fi
Externí odkaz:
https://doaj.org/article/bfeb0e9c16e84018b805b3d540fe3b9c
Autor:
Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppr
Externí odkaz:
https://doaj.org/article/6b54770221c34086b376c539aef6277a
Autor:
Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Maria Kleppe, Michael Ginsberg, Michael J. P. Crowley, Olivier Elemento, Ross L. Levine, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, Jason M. Butler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoieti
Externí odkaz:
https://doaj.org/article/95743d5eec914dfda2ea75f85a602491
Autor:
Michael G. Poulos, Michael J.P. Crowley, Michael C. Gutkin, Pradeep Ramalingam, William Schachterle, Jean-Leon Thomas, Olivier Elemento, Jason M. Butler
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 881-894 (2015)
Hematopoietic stem cells (HSCs) inhabit distinct microenvironments within the adult bone marrow (BM), which govern the delicate balance between HSC quiescence, self-renewal, and differentiation. Previous reports have proposed that HSCs localize to th
Externí odkaz:
https://doaj.org/article/06c03862ec6a47019427c26a553e3d6c
Autor:
Michael G. Poulos, Peipei Guo, Natalie M. Kofler, Sandra Pinho, Michael C. Gutkin, Anastasia Tikhonova, Iannis Aifantis, Paul S. Frenette, Jan Kitajewski, Shahin Rafii, Jason M. Butler
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 1022-1034 (2013)
The bone marrow (BM) microenvironment is composed of multiple niche cells that, by producing paracrine factors, maintain and regenerate the hematopoietic stem cell (HSC) pool (Morrison and Spradling, 2008). We have previously demonstrated that endoth
Externí odkaz:
https://doaj.org/article/a2de7d96b8d94890af4dc12d7b19d166
Autor:
Edlira Hoxha, Catherine Diefenbach, Yutong Zhang, Adriana Heguy, Anastasia N. Tikhonova, Stavroula Kousteni, Kishor K. Sivaraj, Aristotelis Tsirigos, Hai Hu, Ralf H. Adams, Igor Dolgalev, Aris N. Economides, Matthew T. Witkowski, Ilseyar Akhmetzyanova, Michael C. Gutkin, Jason M. Butler, Maria Guillamot, Álvaro Cuesta-Domínguez, Jie Gao, Sandra Pinho, Hua Zhong, Paul S. Frenette, Rahul Satija, David R. Fooksman, Christian Marier, Iannis Aifantis
Publikováno v:
Nature
The molecular complexity of the bone marrow (BM) microenvironment and its response to stress are incompletely understood, despite its key role in the regulation of hematopoiesis. Here we map the transcriptional landscape of BM vascular, perivascular,
Autor:
Matthew B. Greenblatt, Elisa Lazzari, David Lopez, Ana G. Freire, Christopher C. Kloss, Michael C. Gutkin, Lizabeth Katsnelson, Christopher Y. Park, Michael J. Crowley, Pradeep Ramalingam, Michael G. Poulos, Jason M. Butler
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Inflammatory signals arising from the microenvironment have emerged as critical regulators of hematopoietic stem cell (HSC) function during diverse processes including embryonic development, infectious diseases, and myelosuppressive injuries caused b
Autor:
Pradeep Ramalingam, Pierre Llanos, Katherine Gilleran, Jason M. Butler, Michael G. Poulos, Sina Y. Rabbany, Michael C. Gutkin
Publikováno v:
Journal of Clinical Investigation. 127:4163-4178
Age-related changes in the hematopoietic compartment are primarily attributed to cell-intrinsic alterations in hematopoietic stem cells (HSCs); however, the contribution of the aged microenvironment has not been adequately evaluated. Understanding th
Autor:
Jason M. Butler, Michael J. Crowley, William Schachterle, Michael C. Gutkin, Michael G. Poulos, Pradeep Ramalingam, Olivier Elemento, Jean-Leon Thomas
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Elsevier, 2015, 5 (5), pp.881-894. ⟨10.1016/j.stemcr.2015.08.018⟩
Stem Cell Reports, Vol 5, Iss 5, Pp 881-894 (2015)
Stem Cell Reports, 2015, 5 (5), pp.881-894. ⟨10.1016/j.stemcr.2015.08.018⟩
Stem Cell Reports, Elsevier, 2015, 5 (5), pp.881-894. ⟨10.1016/j.stemcr.2015.08.018⟩
Stem Cell Reports, Vol 5, Iss 5, Pp 881-894 (2015)
Stem Cell Reports, 2015, 5 (5), pp.881-894. ⟨10.1016/j.stemcr.2015.08.018⟩
Summary Hematopoietic stem cells (HSCs) inhabit distinct microenvironments within the adult bone marrow (BM), which govern the delicate balance between HSC quiescence, self-renewal, and differentiation. Previous reports have proposed that HSCs locali
Publikováno v:
Experimental Hematology. 88:S48
Chronic inflammation within the bone marrow (BM) microenvironment has been proposed as a key driver of aging-associated hematopoietic defects including loss of hematopoietic stem cell (HSC) self-renewal, myeloid-biased HSC differentiation, and a pred