Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Michael C. Gundry"'
Autor:
Lorenzo Brunetti, Giulia Pianigiani, Michael C. Gundry, Margaret A. Goodell, Brunangelo Falini
Publikováno v:
eJHaem, Vol 5, Iss 5, Pp 1028-1032 (2024)
Abstract Background NPM1‐mutated acute myeloid leukemia (AML) is the most frequent AML subtype. As wild‐type NPM1 is known to orchestrate ribosome biogenesis, it has been hypothesized that altered translation may contribute to leukemogenesis and
Externí odkaz:
https://doaj.org/article/18edd592c10b4daa81f70a17f80356e0
Autor:
Yung-Hsin Huang, Jianzhong Su, Yong Lei, Lorenzo Brunetti, Michael C. Gundry, Xiaotian Zhang, Mira Jeong, Wei Li, Margaret A. Goodell
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background DNA methylation has widespread effects on gene expression during development. However, our ability to assign specific function to regions of DNA methylation is limited by the poor correlation between global patterns of DNA methyla
Externí odkaz:
https://doaj.org/article/9ad400dffd3b4ef1a26a5cb5c03bc9b5
Autor:
Yong Lei, Xiaotian Zhang, Jianzhong Su, Mira Jeong, Michael C. Gundry, Yung-Hsin Huang, Yubin Zhou, Wei Li, Margaret A. Goodell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Understanding how DNA methylation regulates gene expression requires the capacity to deploy it to regions of interest. The authors generate a highly rapid and locus-specific CpG methylation tool by fusing dCas9 to MQ1 DNA methyltransferase and show e
Externí odkaz:
https://doaj.org/article/c2215de867694f8d8d9eb31b2329443a
Autor:
Michael C. Gundry, Lorenzo Brunetti, Angelique Lin, Allison E. Mayle, Ayumi Kitano, Dimitrios Wagner, Joanne I. Hsu, Kevin A. Hoegenauer, Cliona M. Rooney, Margaret A. Goodell, Daisuke Nakada
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1453-1461 (2016)
Summary: Our understanding of the mechanisms that regulate hematopoietic stem/progenitor cells (HSPCs) has been advanced by the ability to genetically manipulate mice; however, germline modification is time consuming and expensive. Here, we describe
Externí odkaz:
https://doaj.org/article/a84ef1ca22b448db80fbb63ddf1b86b6
Autor:
Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
Publikováno v:
Nature Cell Biology. 25:528-539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e0acdba8ec88379421a55a615b19d5e
https://doi.org/10.1038/s41556-023-01109-9
https://doi.org/10.1038/s41556-023-01109-9
Publikováno v:
Science Advances. 7
We report a novel single-cell whole-genome amplification method (LCS-WGA) that can efficiently capture spontaneous DNA damage existing in single cells. We refer to these damage-associated single-nucleotide variants as "damSNVs," and the whole-genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1409bcb51653ac0677da125231946850
https://doi.org/10.1126/sciadv.abf3329
https://doi.org/10.1126/sciadv.abf3329
Publikováno v:
International Journal of Hematology. 110:150-160
Acute myeloid leukemia (AML), the most common acute leukemia in adults, increases exponentially with age. While a number of recent advances have improved treatment, high cure rates have not yet been achieved. Nucleophosmin (NPM1) is found mutated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cda031caab5836e05edd7d6563997ce
https://doi.org/10.1007/s12185-018-02578-7
https://doi.org/10.1007/s12185-018-02578-7
Autor:
Geraldo Medrano, Jaime M. Reyes, Tidie Song, Rachel E. Rau, Carlo D. Cristobal, Margaret A. Goodell, Anna Guzman, Jason H. Rogers, Michael C. Gundry, Rogelio Aguilar, Kristen Kurtz, Lorenzo Brunetti, Shannon E Conneely, Cade Johnson, Sean Barnes, Rohit Gupta
Publikováno v:
Blood Adv
IKAROS family zinc finger 1 (IKZF1) alterations represent a diverse group of genetic lesions that are associated with an increased risk of relapse in B-lymphoblastic leukemia (B-ALL). Due to the heterogeneity of concomitant lesions it remains unclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c6d38c064d74332280fe1fbcd6181b
https://doi.org/10.1101/2020.05.26.109579
https://doi.org/10.1101/2020.05.26.109579
Autor:
Richard E. Champlin, Gavin Kurgan, Luis Muniz-Feliciano, Nadima Uprety, Pinaki P. Banerjee, Elizabeth J. Shpall, Mustafa Bdaiwi, David Marin, Mark A. Behlke, Ana Karen Nunez Cortes, Sunil Acharya, Junjun Lu, Emily Ensley, Vandana Nandivada, Mayela Mendt, Li Li, Stephan Mielke, Sonny Ang, Enli Liu, Mayra Hernandez Sanabria, Rafet Basar, Rolf Turk, Alexander D. Kontoyiannis, Lorenzo Brunetti, Mecit Kaplan, May Daher, Garrett R. Rettig, Matthew S. McNeill, Lucila Nassif Kerbauy, Sufang Li, Abdullah Alsuliman, Ye Li, Elif Gokdemir, Natalie W. Fowlkes, Gonca Ozcan, Mollie S. Schubert, Michael C. Gundry, Katayoun Rezvani
Publikováno v:
Blood Adv
Virus-specific T cells have proven highly effective for the treatment of severe and drug-refractory infections after hematopoietic stem cell transplant (HSCT). However, the efficacy of these cells is hindered by the use of glucocorticoids, often give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c6d8db110db396438e1a7d629615f3
http://hdl.handle.net/11391/1475147
http://hdl.handle.net/11391/1475147
Publikováno v:
Cancer Cell
Inhibition of the Menin (MEN1) and MLL (MLL1, KMT2A) interaction is a potential therapeutic strategy for MLL-rearranged (MLL-r) leukemia. Structure-based design yielded the potent, highly selective and orally-bioavailable small molecule inhibitor VTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6a2aa081c13a2518685b944bf88634
http://hdl.handle.net/11391/1462223
http://hdl.handle.net/11391/1462223