Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael C. Cavalier"'
Autor:
Milad J Alasady, Alexander R Terry, Adam D Pierce, Michael C Cavalier, Catherine S Blaha, Kaylin A Adipietro, Paul T Wilder, David J Weber, Nissim Hay
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256238 (2021)
S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling.
Externí odkaz:
https://doaj.org/article/9e8cdda96b274951af8b33b4ddfe5607
Autor:
Avanish K Varshney, Galina A Kuzmicheva, Jian Lin, Kevin M Sunley, Rodney A Bowling, Tzu-Yu Kwan, Heather R Mays, Anu Rambhadran, Yanfeng Zhang, Rebecca L Martin, Michael C Cavalier, John Simard, Sushma Shivaswamy
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190537 (2018)
Staphylococcus aureus can cause devastating and life-threatening infections. With the increase in multidrug resistant strains, novel therapies are needed. Limited success with active and passive immunization strategies have been attributed to S. aure
Externí odkaz:
https://doaj.org/article/cee8b261e24848b49ea2d2c8f81fb79b
Autor:
Michael C Cavalier, Young-Sun Yim, Shumpei Asamizu, David Neau, Khaled H Almabruk, Taifo Mahmud, Yong-Hwan Lee
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44934 (2012)
The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate,
Externí odkaz:
https://doaj.org/article/022bc0efb7af4be0bd5020bf7b3b07c1
Autor:
Catherine Blaha, Milad J. Alasady, Paul T. Wilder, Michael C. Cavalier, Kaylin A. Adipietro, Alexander R. Terry, Adam D. Pierce, David J. Weber, Nissim Hay
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256238 (2021)
PLoS ONE
PLoS ONE
S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling.
Autor:
Adam D. Pierce, Padmavani Bezawada, David B. Neau, E. Prabhu Raman, David J. Weber, Paul T. Wilder, Kristen M. Varney, Eric A. Toth, Andrew Coop, Laura E. McKnight, Michael C. Cavalier, Alexander D. MacKerell, Milad J. Alasady, Mohd. Imran Ansari, Thomas H. Charpentier
Publikováno v:
Journal of Medicinal Chemistry. 59:592-608
The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B·p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. However, off-target effects associated with this drug were problematic in MM pa
Autor:
Lijia Chen, Jeremy L. Yap, Brandon Drennen, Mithun Raje, Paul T. Wilder, Maryanna E. Lanning, Steven Fletcher, H. Bailey, Michael C. Cavalier
Publikováno v:
Organic & Biomolecular Chemistry. 13:8642-8646
Mimicry of two faces of an α-helix might yield more potent and more selective inhibitors of dysregulated, helix-mediated protein–protein interactions (PPI). Herein, we demonstrate that a 2,6,9-tri-substituted purine is capable of disrupting the Mc
Autor:
David J. Maloney, Milad J. Alasady, Anton Simeonov, David B. Neau, Eric A. Toth, David J. Weber, Michael C. Cavalier, Adam D. Pierce, Timothy L. Foley, Paul T. Wilder, Kira G. Hartman, Ajit Jadhav
Publikováno v:
Biochemistry
Elevated levels of the tumor marker S100B are observed in malignant melanoma, and this EF-hand-containing protein was shown to directly bind wild-type (wt) p53 in a Ca(2+)-dependent manner, dissociate the p53 tetramer, and inhibit its tumor suppressi
Autor:
E. Aligholizadeh, Adam D. Pierce, Paul T. Wilder, Milad J. Alasady, Michael C. Cavalier, Zephan Melville, E.P. Raman, David J. Weber, Alex D. MacKerell, Wenbo Yu, Lei Fang
Structure-based drug discovery is under way to identify and develop small-molecule S100B inhibitors (SBiXs). Such inhibitors have therapeutic potential for treating malignant melanoma, since high levels of S100B downregulate wild-type p53 tumor suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d61d7306e866a6614c4515f8db2e7b4
https://europepmc.org/articles/PMC4908867/
https://europepmc.org/articles/PMC4908867/
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 80:1143-1153
The molecular basis of fructose-2,6-bisphosphatase (F-2,6-P(2)ase) of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB) was investigated using the crystal structures of the human inducible form (PFKFB3) in a phospho-enzyme intermediate sta
Autor:
William S. Blaner, Oliver B. Clarke, Yunting Chen, Joachim Frank, Jonathan Kim, Zahra Assur, Michael C. Cavalier, Désirée von Alpen, Raquel Godoy-Ruiz, Sean D. Stowe, Lawrence Shapiro, Youn-Kyung Kim, David J. Weber, Filippo Mancia, Chiara Manzini, Loredana Quadro, Wayne A. Hendrickson
Publikováno v:
Science (New York, N.Y.). 353(6302)
INTRODUCTION Vitamin A is an essential nutrient for all mammals, being vital for vision and for transcription of a wide array of genes. Retinol (vitamin A alcohol) is the predominant circulating retinoid. In the fasting state, retinol from liver stor