Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Michael C. Barber"'
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 288:E1179-E1187
We have developed a mouse model of diet-induced obesity that shows numerous abnormalities relating to mammary gland function. Animals ate approximately 40% more calories when offered a high-fat diet and gained weight at three times the rate of contro
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1664(2):206-216
The transport of l -leucine by two human breast cancer cell lines has been examined. l -Leucine uptake by MDA-MB-231 and MCF-7 cells was via a BCH-sensitive, Na+-independent pathway. l -Leucine uptake by both cell lines was inhibited by l -alanine, d
Autor:
Nigel T. Price, Michael C. Barber, Amanda J. Vallance, Roger A. Clegg, R.Y. Thomson, Maureen T. Travers
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1634:97-106
mRNA encoding a variant acetyl-CoA carboxylase (ACC)-alpha isozyme, transcribed from a downstream promoter, PIII, was detected in human tissues. Such exon 5A-containing transcripts (E5A-mRNA) encode ACC-alpha with a distinct N-terminus, with 15/17 re
Autor:
Michael C. Barber, Richard G. Vernon, John H. Shand, Gordon J. Allan, Maureen T. Travers, David J. Flint, Elizabeth Tonner, Paul A. Kelly, Nadine Binart
Publikováno v:
Endocrinology. 143:4310-4319
The heterozygous prolactin (PRL) receptor (PRLR+/−) mouse fails to develop a fully functional mammary gland at the end of the first pregnancy and shows markedly impaired lobuloalveolar development and milk secretion in young females. PRL and GH, ac
Autor:
Maureen T. TRAVERS, Amanda J. VALLANCE, Helen T. GOURLAY, Clare A. GILL, Izabella KLEIN, Cynthia B. K. BOTTEMA, Michael C. BARBER
Publikováno v:
Biochemical Journal. 359:273-284
Acetyl-CoA carboxylase-α (ACC-α) plays a central role in co-ordinating de novo fatty acid synthesis in animal tissues. We have characterized the regulatory region of the ovine ACC-α gene. Three promoters, PI, PII and PIII, are dispersed throughout
Publikováno v:
INRAE Productions Animales. 12:319-327
D’après le rapport présenté lors du Symposium satellite "Lipogenèse chez les animaux domestiques" dans le cadre des 3èmes Journées franco-britanniques de Nutrition (Nancy, 30 septembre - 2 octobre 1998), publié en langue anglaise dans Procee
Publikováno v:
Proceedings of the Nutrition Society. 58:541-549
Lipogenesis occurs in all vertebrate species and has a critical role in energy balance, providing a means whereby excess energy can be stored as a fat. The metabolic pathways involved and their tissue distribution in different species, including man,
Autor:
Richard J. Ward, Peter J. Buttery, Michael C. Barber, S. E. Richards, Andrew M. Salter, Richard G. Vernon, Maureen T. Travers
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1391:145-156
Clones corresponding to ovine stearoyl-CoA desaturase (SCD) cDNA were isolated from an adipose tissue cDNA library. All of these clones represented a single mRNA species as judged by restriction fragment and DNA sequence analysis. RNase protection an
Publikováno v:
Endocrinology. 138:5101-5107
We have demonstrated a 50-fold increase in the concentration of insulin-like growth factor-binding protein-5 (IGFBP-5) in milk after 2 days of mammary involution induced by removal of the suckling young. IGFBP-5 was identified by its immunoreactivity
Autor:
Maureen T. Travers, David J. Flint, C J Wilde, L Quarrie, Elizabeth Tonner, Michael C. Barber
Publikováno v:
Endocrinology. 137:1530-1539
We have compared involution of the rat mammary gland, induced by litter removal, where milk accumulation occurs, with involution induced in the presence of the suckling young by combined PRL and GH deficiency. Both treatments induced involutionary pr