Výsledky vyhledávání - "Michael C. Babin"

Development of a hydrogen cyanide inhalation exposure system and determination of the inhaled median lethal dose in the swine model

Autor: M. Claire Matthews, Matthew K. Brittain, Mark R. Perry, Jillian M. Staugler, Michael C. Babin

Publikováno v: Inhalation Toxicology. 30:195-202

Cyanide is a highly toxic chemical, and acute exposure depletes cells and tissue of oxygen, depressing the respiratory, cardiovascular and neurological systems and potentially leading to death. Cyanide has been used as a weapon since ancient Rome and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01cb9bd98b4f59233e58a5f7bb7ec52
https://doi.org/10.1080/08958378.2018.1494764

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Kinetic analysis of oxime-assisted reactivation of human, Guinea pig, and rat acetylcholinesterase inhibited by the organophosphorus pesticide metabolite phorate oxon (PHO)

Autor: Kevin G. McGarry, Robert A. Moyer, Michael C. Babin, David T. Yeung, David A. Jett, Gennady E. Platoff

Publikováno v: Pesticide Biochemistry and Physiology. 145:93-99

Phorate is a highly toxic agricultural pesticide currently in use throughout the world. Like many other organophosphorus (OP) pesticides, the primary mechanism of the acute toxicity of phorate is acetylcholinesterase (AChE) inhibition mediated by its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81c79c74d43dd44d3278ed7b7ef096
https://doi.org/10.1016/j.pestbp.2018.01.009

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An inhalational swine model for the characterization of physiological effects and toxicological profile associated with cyanide poisoning

Autor: Jillian M. Staugler, Michael C. Babin, Mark R. Perry, Dinelia Rivera-Burgos, Thomas Vinci

Cyanides are highly toxic compounds that have been used as weapons of terrorism throughout history. Cyanide (CN) is acutely toxic by all routes of administration; however, inhalation is the main exposure route. To adequately test effective countermea

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Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in the Hartley guinea pig

Autor: Christina M. Wilhelm, Michael C. Babin, Gennady E. Platoff, Thomas H. Snider, David A. Jett, David T. Yeung

Organophosphorus (OP) compounds, including pesticides and chemical warfare nerve agents (CWNA), are threats to the general population as possible weapons of terrorism or by accidental exposure whether through inadvertent release from manufacturing fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33797c6913fb6a227f0fde736cb90a60
https://europepmc.org/articles/PMC6153028/

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A novel sulfur mustard (HD) vapor inhalation exposure system for accurate inhaled dose delivery

Autor: Michael C. Babin, David T. Yeung, Jennifer L. Plahovinsak, Jonathon W. Kohne, Gennady E. Platoff, Eric Benson, Mark R. Perry

Publikováno v: Journal of Pharmacological and Toxicological Methods. 71:120-128

Introduction A custom designed HD exposure system was used to deliver controlled inhaled doses to an animal model through an endotracheal tube. Methods Target HD vapor challenges were generated by a temperature controlled bubbler/aerosol trap, while

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f45eec7d3fb15c5b89a6cffcb816741
https://doi.org/10.1016/j.vascn.2014.09.009

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Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat

Autor: David A. Jett, Michael C. Babin, Kevin G. McGarry, Thomas H. Snider, Gennady E. Platoff, David T. Yeung

Publikováno v: Fundamental toxicological sciences. 3(5)

The oral toxicity of phorate oxon (PHO), with emphasis on gender- and age-related effects, was characterized in the Sprague-Dawley rat. The oral LD50 (95% fiducial limits) for PHO in corn oil was 0.88 (0.79, 1.04) mg/kg in males and 0.55 (0.46, 0.63)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3f48e66c750bbce932cd83d19192a5
https://pubmed.ncbi.nlm.nih.gov/28856079

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A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides

Autor: Michael C. Babin, David T. Yeung, Thomas H. Snider, Gennady E. Platoff, David A. Jett, Christina M. Wilhelm

Publikováno v: Toxicology and Applied Pharmacology. 281(3):254-265

The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylc

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Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig

Autor: David A. Jett, Thomas H. Snider, Gennady E. Platoff, Michael C. Babin, David T. Yeung

Publikováno v: The Journal of toxicological sciences. 41(4)

Anticholinesterases, such as organophosphorus pesticides and warfare nerve agents, present a significant health threat. Onset of symptoms after exposure can be rapid, requiring quick-acting, efficacious therapy to mitigate the effects. The goal of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2aeea674e206f96cb3ee05524af42c5
https://pubmed.ncbi.nlm.nih.gov/27432237

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Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection

Autor: Tanya Burney, Michael C. Babin, Sari B. Mahon, Vikhyat S. Bebarta, Renate B. Pilz, David Mukai, Matthew Brenner, David Yoon, Gerry R. Boss, Matthew K. Brittain, Norma Garrett, Adriano Chan

Publikováno v: Bebarta, VS; Brittain, M; Chan, A; Garrett, N; Yoon, D; Burney, T; et al.(2017). Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. ANNALS OF EMERGENCY MEDICINE, 69(6), 718-725. doi: 10.1016/j.annemergmed.2016.09.034. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5n44t6fs

The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection woul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165833c23dd56dfe6c40c801d924c667
https://pubmed.ncbi.nlm.nih.gov/28041825

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Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig

Autor: Michael C. Babin, Matthew K. Brittain, David T. Yeung, David A. Jett, Gennady E. Platoff, Kevin G. McGarry, Robert A. Moyer

Publikováno v: International journal of toxicology. 35(3)

Purpose: Aldicarb and methomyl are carbamate pesticides commonly implicated in human poisonings. The primary toxic mechanism of action for carbamate poisoning is cholinesterase (ChE) inhibition. As such, it is logical to assume that the currently acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9267f06605943624324124c09b5d62dd
https://pubmed.ncbi.nlm.nih.gov/27102179

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