Výsledky vyhledávání - "Michael C. Appel"

Akademický článek

Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.

Autor: Madelyn R Schmidt, Michael C Appel, Lisa J Giassi, Dale L Greiner, Leonard D Shultz, Robert T Woodland

Publikováno v: PLoS ONE, Vol 3, Iss 9, p e3192 (2008)

The production of fully immunologically competent humanized mice engrafted with peripheral lymphocyte populations provides a model for in vivo testing of new vaccines, the durability of immunological memory and cancer therapies. This approach is limi

Externí odkaz: https://doaj.org/article/59ea7d7742ab4ed78b610efbe3a2e603

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Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice

Autor: Hideyuki Masaki, Leonard D. Shultz, Michael C. Appel, Jean Leif, Aldo A. Rossini, Linda Paquin, John P. Mordes, Dale L. Greiner, Linda Leahy

Publikováno v: Xenotransplantation. 13:224-232

Masaki H, Appel MC, Leahy L, Leif J, Paquin L, Shultz LD, Mordes JP, Greiner DL, Rossini AA. Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be97c8ba5d06556bea75c2550798a40
https://doi.org/10.1111/j.1399-3089.2006.00290.x

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Regulation of Skin and Islet Allograft Survival in Mice Treated With Costimulation Blockade is Mediated by Different CD4+ Cell Subsets and Different Mechanisms

Autor: Jean Leif, Aldo A. Rossini, Michael C. Appel, Dale L. Greiner, Scott J. Banuelos, Amy Cuthbert, Nancy E. Phillips, Thomas G. Markees, Leonard D. Shultz, John P. Mordes

Publikováno v: Transplantation. 78:660-667

Background. Donor-specific transfusion (DST) and a brief course of anti-CD 154 monoclonal antibody (mAb) induces permanent islet and prolonged skin allograft survival in mice. Induction of skin allograft survival requires the presence of CD4 + cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f907b656ece53a7d24767122699c3dfd
https://doi.org/10.1097/01.tp.0000130449.05412.96

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Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1nullPrf1null mice

Autor: Dale L. Greiner, Bruce Gott, Aldo A. Rossini, Leonard D. Shultz, Michael C. Appel, Lisa M. Burzenski, Scott J. Banuelos, Bonnie L. Lyons

Publikováno v: Clinical Immunology. 112:273-283

Immunodeficient NOD mice engrafted with human peripheral blood mononuclear cells (PBMCs) were used in two models of human islet allograft rejection. Model one: human PBMCs were engrafted into chemically diabetic NOD-scid mice bearing established subr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c407929ced011b148ab1fb6ca5c947
https://doi.org/10.1016/j.clim.2004.04.006

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PROLONGED SURVIVAL OF NEONATAL PORCINE ISLET XENOGRAFTS IN MICE TREATED WITH A DONOR-SPECIFIC TRANSFUSION AND ANTI-CD154 ANTIBODY1

Autor: Michael C. Appel, Dale L. Greiner, Aldo A. Rossini, Scott J. Banuelos, John P. Mordes, Leonard D. Shultz

Publikováno v: Transplantation. 77:1341-1349

Background Combined treatment with a single donor-specific transfusion (DST) and a brief course of anti-mouse CD154 monoclonal antibody (mAb) to induce co-stimulation blockade leads to long-term murine islet allograft survival. The authors hypothesiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f006ec1414f7a10c20f0b4a1528851d
https://doi.org/10.1097/01.tp.0000116771.68839.c1

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NOD/LtSz-Rag1 null Pfp null mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment

Autor: Rebecca Samuels, Dale L. Greiner, Bruce Gott, Aldo A. Rossini, Jean Leif, Bonnie L. Lyons, Scott J. Banuelos, Lisa M. Burzenski, Michael C. Appel, Pamela Lang, Leonard D. Shultz

Publikováno v: Transplantation. 76:1036-1042

Background. A critical need exists for effective small-animal models that accept engraftment of human hematopoietic progenitor cells and mature lymphocytes. The purpose of this study was to determine the phenotypic effects of perforin (Pfp) deficienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4326fae54fb4f7ccbec60c3072304730
https://doi.org/10.1097/01.tp.0000083041.44829.2c

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Alloimmune Injury and Rejection of Human Skin Grafts on Human Peripheral Blood Lymphocyte–Reconstituted Non-Obese Diabetic Severe Combined Immunodeficient β2-Microglobulin-Null Mice

Autor: Dale L. Greiner, Michael C. Appel, Leonard D. Shultz, John P. Mordes, Bonnie L. Lyons, Nicole A. Turgeon, Neal N. Iwakoshi, Aldo A. Rossini, Scott J. Banuelos

Publikováno v: Experimental Biology and Medicine. 228:1096-1104

Small animal models with the capacity to support engraftment of a functional human immune system are needed to facilitate studies of human alloimmunity. In the present investigation, non-obese diabetic (NOD) severe combined immunodeficient ( scid) β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1363b09582847e140ef98e39eb4b855c
https://doi.org/10.1177/153537020322800918

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Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells

Autor: Jean Leif, Karen K. Ballen, Lisa M. Burzenski, Michael C. Appel, Leonard D. Shultz, Melody Cunningham, Dale L. Greiner, Scott J. Banuelos

Publikováno v: Experimental Hematology. 31:551-558

Objective. NOD/SCID and NOD/SCID B2m null mice are used for the in vivo study of human hematopoietic stem cells (HSC). A previously unrecognized HSC in cord blood, termed short-term repopulating cell (STRC), has been identified using NOD/SCID B2m nul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a4e3f79434ed227f3740b705977902
https://doi.org/10.1016/s0301-472x(03)00076-6

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Precoating expanded polytetrafluoroethylene grafts alters production of endothelial cell—derived thrombomodulators

Autor: Michael C. Appel, Valerie A. Klassen, Michael J. Rohrer, Michael J. Menconi, H. Brownell Wheeler, Jian-ming Li, Jack Ansell

Publikováno v: Journal of Vascular Surgery. 15:1010-1017

Although the use of extracellular matrix proteins to precoat small-caliber vascular grafts before endothelial cell seeding has been shown to improve cell attachment, proliferation, and adherence, the effect of precoating on the thrombomodulatory prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::301b02bb37c7350de3197ed9b407cd3a
https://doi.org/10.1016/0741-5214(92)90457-j

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Iodine Content of Rat Thyroglobulin Affects its Antigenicity in Inducing Lymphocytic Thyroiditis in the BB/Wor Rat

Autor: Sharon Alex, Michael C. Appel, Lewis E. Braverman, Shih Lieh Fang, Susana A. Ebner, Wasana Lueprasitsakul

Publikováno v: Autoimmunity. 13:209-214

The BB/Wor rat develops spontaneous insulin dependent diabetes mellitus (DM) and lymphocytic thyroiditis (LT). We have recently demonstrated that immunization of BB/Wor rats with allogeneic thyroglobulin (Tg) induces LT at an early age. The incidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24db2a363bb5d7b5348ff4d210330d01
https://doi.org/10.3109/08916939209004826

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