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of 165
pro vyhledávání: '"Michael C Wu"'
Correction: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Autor:
Naila Haq, Christoph Schmidt-Hieber, Fernando J Sialana, Lorenza Ciani, Janosch P Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J Rodenburg, Patrick M Nolan, Elizabeth Forsythe, Michael C Wu, Gert Lubec, Patricia C Salinas, Michael Häusser, Philip L Beales, Sofia Christou-Savina
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000520 (2019)
[This corrects the article DOI: 10.1371/journal.pbio.3000414.].
Externí odkaz:
https://doaj.org/article/e9e4591deded4a4d8c04f40819a54f18
Autor:
Naila Haq, Christoph Schmidt-Hieber, Fernando J Sialana, Lorenza Ciani, Janosch P Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J Rodenburg, Patrick M Nolan, Elizabeth Forsythe, Michael C Wu, Gert Lubec, P Salinas, Michael Häusser, Philip L Beales, Sofia Christou-Savina
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000414 (2019)
Bardet-Biedl syndrome (BBS), a ciliopathy, is a rare genetic condition characterised by retinal degeneration, obesity, kidney failure, and cognitive impairment. In spite of progress made in our general understanding of BBS aetiology, the molecular an
Externí odkaz:
https://doaj.org/article/476db0f2540d4ebfa5d72cbe98ee01fd
Autor:
Tiffany Hensley-McBain, Michael C Wu, Jennifer A Manuzak, Ryan K Cheu, Andrew Gustin, Connor B Driscoll, Alexander S Zevin, Charlene J Miller, Ernesto Coronado, Elise Smith, Jean Chang, Michael Gale, Ma Somsouk, Adam D Burgener, Peter W Hunt, Thomas J Hope, Ann C Collier, Nichole R Klatt
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007672 (2019)
Gastrointestinal (GI) mucosal dysfunction predicts and likely contributes to non-infectious comorbidities and mortality in HIV infection and persists despite antiretroviral therapy. However, the mechanisms underlying this dysfunction remain incomplet
Externí odkaz:
https://doaj.org/article/c8db3329e3b74305971fa5b384d2eb98
Autor:
Rachel Marceau West, Wenbin Lu, Daniel M Rotroff, Melaine A Kuenemann, Sheng-Mao Chang, Michael C Wu, Michael J Wagner, John B Buse, Alison A Motsinger-Reif, Denis Fourches, Jung-Ying Tzeng
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006722 (2019)
Rare variants are of increasing interest to genetic association studies because of their etiological contributions to human complex diseases. Due to the rarity of the mutant events, rare variants are routinely analyzed on an aggregate level. While ag
Externí odkaz:
https://doaj.org/article/cfa869d9762a4af085de4661762e40ed
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
IntroductionRepeated measures microbiome studies, including longitudinal and clustered designs, offer valuable insights into the dynamics of microbial communities and their associations with various health outcomes. However, visualizing such multivar
Externí odkaz:
https://doaj.org/article/afeebebdb6ae4e36aa1189eb663c57d2
Autor:
Naoki Tajiri, David M Quach, Yuji Kaneko, Stephanie Wu, David Lee, Tina Lam, Ken L Hayama, Thomas G Hazel, Karl Johe, Michael C Wu, Cesar V Borlongan
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91408 (2014)
Stroke is a major cause of death and disability, with very limited treatment option. Cell-based therapies have emerged as potential treatments for stroke. Indeed, studies have shown that transplantation of neural stem cells (NSCs) exerts functional b
Externí odkaz:
https://doaj.org/article/414b27477b7044cf9c7503f5e32057af
Autor:
Ian M Carroll, Tamar Ringel-Kulka, Laurent Ferrier, Michael C Wu, Jennica P Siddle, Lionel Bueno, Yehuda Ringel
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78017 (2013)
OBJECTIVE:Intestinal proteases carry out a variety of functions in the gastrointestinal (GI) tract. Studies have reported that elevated enteric proteases in patients with GI disease can alter intestinal physiology, however the origin (human vs. micro
Externí odkaz:
https://doaj.org/article/ccc83927cfb6424b8250eee846c0d8e3
Autor:
Hongjiao Liu, Wodan Ling, Xing Hua, Jee-Young Moon, Jessica S. Williams-Nguyen, Xiang Zhan, Anna M. Plantinga, Ni Zhao, Angela Zhang, Rob Knight, Qibin Qi, Robert D. Burk, Robert C. Kaplan, Michael C. Wu
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Background Understanding human genetic influences on the gut microbiota helps elucidate the mechanisms by which genetics may influence health outcomes. Typical microbiome genome-wide association studies (GWAS) marginally assess the associati
Externí odkaz:
https://doaj.org/article/198f7a84d6c048ee9cd0fcb3451401e4
Autor:
Hoseung Song, Wodan Ling, Ni Zhao, Anna M. Plantinga, Courtney A. Broedlow, Nichole R. Klatt, Tiffany Hensley-McBain, Michael C. Wu
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Microbial communities are known to be closely related to many diseases, such as obesity and HIV, and it is of interest to identify differentially abundant microbial species between two or more environments. Since the abundances or
Externí odkaz:
https://doaj.org/article/7478464c58bc477f98f48d5f4a4f1bfd
Autor:
Kayla A. Carter, Anthony A. Fodor, Jennifer E. Balkus, Angela Zhang, Myrna G. Serrano, Gregory A. Buck, Stephanie M. Engel, Michael C. Wu, Shan Sun
Publikováno v:
mSystems, Vol 8, Iss 2 (2023)
ABSTRACT Several studies have compared metagenome inference performance in different human body sites; however, none specifically reported on the vaginal microbiome. Findings from other body sites cannot easily be generalized to the vaginal microbiom
Externí odkaz:
https://doaj.org/article/84caa10b76bc4f28807612c81e85ccc0