Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Michael C Velarde"'
Publikováno v:
Endocrine Connections, Vol 12, Iss 11, Pp 1-9 (2023)
Endometriosis is a chronic, debilitating disease characterized by the growth of endometrial tissues outside the endometrium. Its prevalence seems to differ across ethnicities, with the disease affecting and presenting with advanced stages in Asians m
Externí odkaz:
https://doaj.org/article/6fae4ad065944cd6986179a5ab693acb
Autor:
Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy, Dudley W. Lamming
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rapamycin extends lifespan in model organisms by targeting mTORC1, but exerts off-target side effects via inhibition of mTORC2. Here, the authors report the identification of a selective mTORC1 inhibitor, and show that it inhibits mTORC1 activity bot
Externí odkaz:
https://doaj.org/article/62fe1b728b0148059e306c8857df6c69
Autor:
Judith Campisi, Pierre-Yves Desprez, Chandani Limbad, Christopher D. Wiley, Albert R. Davalos, Marco Demaria, Michael C. Velarde, Jose Flores, Diego A. Diaz, Elijah Jones, Emily Chang, Sena Alptekin, Alexis Valdovinos, Tanya Pulido, Fatouma Alimirah
Supplementary Data supporting the manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59381d521715fc65caf131847259a20
https://doi.org/10.1158/0008-5472.22425504
https://doi.org/10.1158/0008-5472.22425504
Autor:
Judith Campisi, Pierre-Yves Desprez, Chandani Limbad, Christopher D. Wiley, Albert R. Davalos, Marco Demaria, Michael C. Velarde, Jose Flores, Diego A. Diaz, Elijah Jones, Emily Chang, Sena Alptekin, Alexis Valdovinos, Tanya Pulido, Fatouma Alimirah
Cellular senescence entails an irreversible growth arrest that evolved in part to prevent cancer. Paradoxically, senescent cells secrete proinflammatory and growth-stimulatory molecules, termed the senescence-associated secretory phenotype (SASP), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbf005205af3a3a2da05c292515bfa6
https://doi.org/10.1158/0008-5472.c.6512058.v1
https://doi.org/10.1158/0008-5472.c.6512058.v1
In silicoassessment of the association of pathogenicity and metal-resistance potential ofFusariumspp
GenusFusariumincludes ubiquitous species complexes and are often resistant to multiple stressors. Early epidemiological evidence show that metal resistance genes (MRGs) influence the spread of antibiotic resistance genes (ARGs) in microbial communiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80dc99175e76ce523c74e5833fb377f6
https://doi.org/10.1101/2022.10.12.511937
https://doi.org/10.1101/2022.10.12.511937
Autor:
Jortan O. Tun, Lilibeth A. Salvador-Reyes, Michael C. Velarde, Naoki Saito, Khanit Suwanborirux, Gisela P. Concepcion
Publikováno v:
Marine Drugs, Vol 17, Iss 9, p 536 (2019)
Renieramycin M (RM) is a KCN-stabilized tetrahydroisoquinoline purified from the blue sponge Xestospongia sp., with nanomolar IC50s against several cancer cell lines. Our goal is to evaluate its combination effects with doxorubicin (DOX) in estrogen
Externí odkaz:
https://doaj.org/article/03a730071b2b4d469ce4178e708fed97
Publikováno v:
Cells. 12:860
Metastasis is a systemic condition and the major challenge among cancer types, as it can lead to multiorgan vulnerability. Recently, attention has been drawn to cellular senescence, a complex stress response condition, as a factor implicated in metas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b322b0523f6e123169c0dd81897c13
https://doi.org/10.3390/cells12060860
https://doi.org/10.3390/cells12060860
Autor:
Michael C. Velarde, Irene L. Tan
Publikováno v:
Current Molecular Biology Reports. 7:20-29
Cellular senescence is implicated in aging and age-related diseases. Because mitochondrial stress is one of the triggers of cellular senescence, and senescence leads to the accumulation of abnormal mitochondria with impaired dynamics and hampered hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a6dbc291fde004e23bd7ba10c835014
https://doi.org/10.1007/s40610-021-00143-6
https://doi.org/10.1007/s40610-021-00143-6
Autor:
Joshua P. Olorocisimo, Leomir A. Diaz, Daniel E. Co, Harold M. Carag, Joyce A. Ibana, Michael C. Velarde
Publikováno v:
Neuropharmacology. 225
Certain bacteria possess the ability to reduce anxiety- and stress-related behaviors through the gut microbiome-brain axis. Such bacteria are called psychobiotics, and can be used to improve mood and cognition. However, only a few bacteria have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5995589abe0b1b0e2f29f553ae8b48
https://pubmed.ncbi.nlm.nih.gov/36565853
https://pubmed.ncbi.nlm.nih.gov/36565853
Autor:
Rodney B. Dofitas, Joji Marie Y. Teves, Michael C. Velarde, Leomir A. Diaz, Gemma Leonora Uy, Ma Antonia E Habana, Juan C. Irwin, Linda C. Giudice, Alison Faye O. Chan, Shiela S. Macalindong, Ana Victoria V Dy Echo, Roy Gerona, Ma Easter Joy V. Sajo, Allen Joy M. Corachea, Apple P. Valparaiso
Publikováno v:
Biopreservation and Biobanking. 18:180-188
Biobanking has become an indispensable tool for translational research and health innovations. While the field of biobanking has progressed and evolved globally, biobanking in developing Association of Southeast Asian Nations (ASEAN) countries such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0989f40ac4603f0657fc1caed8cb271
https://doi.org/10.1089/bio.2019.0114
https://doi.org/10.1089/bio.2019.0114