Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Michael C Ryan"'
Autor:
Michael C. Ryan, Mark Stucky, Chris Wakefield, James M. Melott, Rehan Akbani, John N. Weinstein, Bradley M. Broom
Publikováno v:
F1000Research, Vol 8 (2020)
Clustered heat maps are the most frequently used graphics for visualization and interpretation of genome-scale molecular profiling data in biology. Construction of a heat map generally requires the assistance of a biostatistician or bioinformatics an
Externí odkaz:
https://doaj.org/article/86de6af73e1543a08d07c1eabdac3754
Autor:
John N. Weinstein, Rehan Akbani, Tod D. Casasent, Chris Wakefield, James Melott, David W. Kane, Mark Stucky, Futa Ikeda, Robert E. Brown, Michael C. Ryan, Bradley M. Broom
Figure showing the NG-CHM Generator in the Galaxy bioinformatics platform.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33115e7e612e7de35e28c5428b173209
https://doi.org/10.1158/0008-5472.22418393
https://doi.org/10.1158/0008-5472.22418393
Autor:
Yves Pommier, Barry R. Zeeberg, Hongfang Liu, Kurt W. Kohn, Sudhir Varma, Scott E. Martin, Michael C. Ryan, Stéphanie Solier
Topoisomerase I (Top1) relaxes DNA supercoiling by forming transient cleavage complexes (Top1cc) up- and downstream of transcription complexes. Top1cc can be trapped by carcinogenic and endogenous DNA lesions and by camptothecin, resulting in transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6ce24f9907eb82096495c0116cf055
https://doi.org/10.1158/0008-5472.c.6504687.v1
https://doi.org/10.1158/0008-5472.c.6504687.v1
Autor:
Yves Pommier, Barry R. Zeeberg, Hongfang Liu, Kurt W. Kohn, Sudhir Varma, Scott E. Martin, Michael C. Ryan, Stéphanie Solier
PDF file - 2059K, Importance of Exon numbers for transcript downregulation by CPT (SF1); CPT up-regulates the p53 signaling pathway genes (SF2); Down-regulation of RNA degradation-related genes after CPT treatment (SF3); Down-regulation of ubiquitin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cba4d54bb612fee976a6be33f26f31
https://doi.org/10.1158/0008-5472.22396890
https://doi.org/10.1158/0008-5472.22396890
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1136-1152 (2016)
A full account of our efforts toward an asymmetric redox bicycloisomerization reaction is presented in this article. Cyclopentadienylruthenium (CpRu) complexes containing tethered chiral sulfoxides were synthesized via an oxidative [3 + 2] cycloaddit
Externí odkaz:
https://doaj.org/article/5784d11790c942d886af96cf5f2c63ca
Autor:
Maurizio Chiriva-Internati, Lucia Piccotti, Luca Zammataro, Michael C Ryan, Leonardo Mirandola
Publikováno v:
Cell and Gene Therapy Insights. 7:1471-1485
Autor:
James B. Gerken, Fei Wang, Yeon Jung Kim, Joseph R. Martinelli, Michael M. Aristov, Shannon S. Stahl, Michael C. Ryan
Publikováno v:
Chemical Science
Catalytic N–N coupling is a valuable transformation for chemical synthesis and energy conversion. Here, mechanistic studies are presented for two related copper-catalyzed oxidative aerobic N–N coupling reactions, one involving the synthesis of a
Autor:
Michael C. Ryan, Eunjung Kim, Xufeng Cao, Walter Reichard, Tyler J. Ogorek, Pronay Das, Colleen B. Jonsson, Jerome Baudry, Donghoon Chung, Jennifer E. Golden
Publikováno v:
ACS medicinal chemistry letters. 13(4)
Venezuelan and eastern equine encephalitis viruses are disease-causing, neuropathic pathogens with no approved treatment options in humans. While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone rearrangement
Autor:
Oluwatobi O Idowu, Robert C. Kersten, Michael C. Ryan, Davin C. Ashraf, M. Reza Vagefi, Evan Kalin-Hajdu
Publikováno v:
Ophthalmic Plastic & Reconstructive Surgery. 35:182-186
PURPOSE Pain relief for a blind painful eye often follows an escalating paradigm of interventions. This study compares the efficacy of common interventions. METHODS A retrospective chart review of blind painful eye cases was conducted at a single ter
OmicPioneer-sc: an integrated, interactive visualization environment for single-cell sequencing data
Autor:
Jun Ma, Nicholas Navin, Mary A. Rohrdanz, Rehan Akbani, Bradley M. Broom, Ganiraju C. Manyam, Ken Chen, John N. Weinstein, Mark Stucky, Vakul Mohanty, Christopher Wakefield, James M. Melott, Michael C. Ryan
OmicPioneer-sc is an open-source data visualization/analysis package that integrates dimensionality-reduction plots (DRPs) such as t-SNE and UMAP with Next-Generation Clustered Heat Maps (NGCHMs) and Pathway Visualization Modules (PVMs) in a seamless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::044ba09fc73fd8ec01537bd4359d0124
https://doi.org/10.1101/2020.10.31.363580
https://doi.org/10.1101/2020.10.31.363580