Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael C Quirk"'
Publikováno v:
Frontiers in Systems Neuroscience, Vol 3 (2009)
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the
Externí odkaz:
https://doaj.org/article/17e9d8c5f5664934b981d940e40c0bb1
Autor:
Matthew D. Hill, Maria-Jesus Blanco, Francesco G. Salituro, Zhu Bai, Jacob T. Beckley, Michael A. Ackley, Jing Dai, James J. Doherty, Boyd L. Harrison, Ethan C. Hoffmann, Tatiana M. Kazdoba, David Lanzetta, Michael Lewis, Michael C. Quirk, Albert J. Robichaud
Publikováno v:
Journal of Medicinal Chemistry. 65:9063-9075
Autor:
Weiting Tang, Jacob T. Beckley, Jin Zhang, Rui Song, Yuchen Xu, Sukhan Kim, Michael C. Quirk, Albert J. Robichaud, Eva Sarai Diaz, Scott J. Myers, James J. Doherty, Michael A. Ackley, Stephen F. Traynelis, Hongjie Yuan
Publikováno v:
Cellular and Molecular Life Sciences. 80
Autor:
Alison L, Althaus, Michael A, Ackley, Gabriel M, Belfort, Steven M, Gee, Jing, Dai, David P, Nguyen, Tatiana M, Kazdoba, Amit, Modgil, Paul A, Davies, Stephen J, Moss, Francesco G, Salituro, Ethan, Hoffmann, Rebecca S, Hammond, Albert J, Robichaud, Michael C, Quirk, James J, Doherty
Publikováno v:
Neuropharmacology
Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABAA receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABAA receptor curre
Autor:
Daniel S, La, Francesco G, Salituro, Gabriel, Martinez Botella, Andrew M, Griffin, Zhu, Bai, Michael A, Ackley, Jing, Dai, James J, Doherty, Boyd L, Harrison, Ethan C, Hoffmann, Tatiana M, Kazdoba, Michael C, Lewis, Michael C, Quirk, Albert J, Robichaud
Publikováno v:
Journal of medicinal chemistry. 62(16)
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(
Autor:
Victor Solo, Emery N. Brown, Riccardo Barbieri, Matthew A. Wilson, David P. Nguyen, Michael C. Quirk, Loren M. Frank
Publikováno v:
Neural Computation. 16:277-307
Neural spike train decoding algorithms and techniques to compute Shan-non mutual information are important methods for analyzing how neural systems represent biological signals. Decoding algorithms are also one of several strategies being used to des
Autor:
Kazu Nakazawa, Linus D. Sun, Michael C. Quirk, Matthew A. Wilson, Laure Rondi-Reig, Susumu Tonegawa
Publikováno v:
Neuron. 38(2):305-315
Lesion and pharmacological intervention studies have suggested that in both human patients and animals the hippocampus plays a crucial role in the rapid acquisition and storage of information from a novel one-time experience. However, how the hippoca
Autor:
Riccardo Barbieri, Michael C. Quirk, Victor Solo, Emery N. Brown, Loren M. Frank, Matthew A. Wilson
Publikováno v:
Neurocomputing. :309-314
The spiking activity of rat CA1 hippocampal place cells during open field foraging can be described with stimulus-response models based on an inhomogeneous Poisson (IP) interspike interval probability model. The spatial structure of this model has be
Publikováno v:
Neurocomputing. :1087-1093
We analyze the stochastic structure of CA1 hippocampal place cell spiking activity with stimulus–response models based on inhomogeneous Poisson (IP), inhomogeneous gamma (IG) and inhomogeneous inverse Gaussian (IIG) interspike interval probability
Publikováno v:
Journal of Neuroscience Methods. 105:25-37
A paradigm for constructing and analyzing non-Poisson stimulus-response models of neural spike train activity is presented. Inhomogeneous gamma (IG) and inverse Gaussian (IIG) probability models are constructed by generalizing the derivation of the i