Výsledky vyhledávání - "Michael C Oldham"

Akademický článek

Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis

Autor: Kerstin Seidel, Pauline Marangoni, Cynthia Tang, Bahar Houshmand, Wen Du, Richard L Maas, Steven Murray, Michael C Oldham, Ophir D Klein

Publikováno v: eLife, Vol 6 (2017)

Investigations into stem cell-fueled renewal of an organ benefit from an inventory of cell type-specific markers and a deep understanding of the cellular diversity within stem cell niches. Using the adult mouse incisor as a model for a continuously r

Externí odkaz: https://doaj.org/article/fee6401a1b9f41a9a0c02bc68a6f2f2f

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Akademický článek

Pleiotropic Mechanisms Indicated for Sex Differences in Autism.

Autor: Ileena Mitra, Kathryn Tsang, Christine Ladd-Acosta, Lisa A Croen, Kimberly A Aldinger, Robert L Hendren, Michela Traglia, Alinoë Lavillaureix, Noah Zaitlen, Michael C Oldham, Pat Levitt, Stanley Nelson, David G Amaral, Irva Hertz-Picciotto, M Daniele Fallin, Lauren A Weiss

Publikováno v: PLoS Genetics, Vol 12, Iss 11, p e1006425 (2016)

Sexual dimorphism in common disease is pervasive, including a dramatic male preponderance in autism spectrum disorders (ASDs). Potential genetic explanations include a liability threshold model requiring increased polymorphism risk in females, sex-li

Externí odkaz: https://doaj.org/article/5c02bf462f364187ba0f2c61578f8f6e

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Akademický článek

The organization of the transcriptional network in specific neuronal classes

Autor: Kellen D Winden, Michael C Oldham, Karoly Mirnics, Philip J Ebert, Christo H Swan, Pat Levitt, John L Rubenstein, Steve Horvath, Daniel H Geschwind

Publikováno v: Molecular Systems Biology, Vol 5, Iss 1, Pp 1-18 (2009)

Abstract Genome‐wide expression profiling has aided the understanding of the molecular basis of neuronal diversity, but achieving broad functional insight remains a considerable challenge. Here, we perform the first systems‐level analysis of micr

Externí odkaz: https://doaj.org/article/c5a330e753914c15ba2461ae3270b95b

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Akademický článek

Distinct and separable roles for EZH2 in neurogenic astroglia

Autor: William W Hwang, Ryan D Salinas, Jason J Siu, Kevin W Kelley, Ryan N Delgado, Mercedes F Paredes, Arturo Alvarez-Buylla, Michael C Oldham, Daniel A Lim

Publikováno v: eLife, Vol 3 (2014)

The epigenetic mechanisms that enable specialized astrocytes to retain neurogenic competence throughout adult life are still poorly understood. Here we show that astrocytes that serve as neural stem cells (NSCs) in the adult mouse subventricular zone

Externí odkaz: https://doaj.org/article/cb1ed4213f4c459aa9c851f670048417

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Akademický článek

Is my network module preserved and reproducible?

Autor: Peter Langfelder, Rui Luo, Michael C Oldham, Steve Horvath

Publikováno v: PLoS Computational Biology, Vol 7, Iss 1, p e1001057 (2011)

In many applications, one is interested in determining which of the properties of a network module change across conditions. For example, to validate the existence of a module, it is desirable to show that it is reproducible (or preserved) in an inde

Externí odkaz: https://doaj.org/article/929bd32445144648a4d9d612637e0187

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Akademický článek

Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain

Autor: Xuying Zhang, Guanxi Xiao, Caroline Johnson, Yuheng Cai, Zachary K. Horowitz, Christine Mennicke, Robert Coffey, Mansoor Haider, David Threadgill, Rebecca Eliscu, Michael C. Oldham, Alon Greenbaum, H. Troy Ghashghaei

Publikováno v: iScience, Vol 26, Iss 3, Pp 106242- (2023)

Summary: The epidermal growth factor receptor (EGFR) plays a role in cell proliferation and differentiation during healthy development and tumor growth; however, its requirement for brain development remains unclear. Here we used a conditional mouse

Externí odkaz: https://doaj.org/article/009e161e25ab4ba485fffac48cf84c13

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