Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Michael C Mahaney"'
Autor:
Sobha Puppala, Kimberly D Spradling-Reeves, Jeannie Chan, Shifra Birnbaum, Deborah E Newman, Anthony G Comuzzie, Michael C Mahaney, John L VandeBerg, Michael Olivier, Laura A Cox
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0271514 (2022)
The purpose of this study was to identify molecular mechanisms by which the liver influences total lesion burden in a nonhuman primate model (NHP) of cardiovascular disease with acute and chronic feeding of a high cholesterol, high fat (HCHF) diet. B
Externí odkaz:
https://doaj.org/article/555a98bccc794b0091e930122d6cf12a
Autor:
Biswapriya B Misra, Sobha R Puppala, Anthony G Comuzzie, Michael C Mahaney, John L VandeBerg, Michael Olivier, Laura A Cox
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214487 (2019)
Atherosclerotic plaques are characterized by an accumulation of macrophages, lipids, smooth muscle cells, and fibroblasts, and, in advanced stages, necrotic debris within the arterial walls. Dietary habits such as high fat and high cholesterol (HFHC)
Externí odkaz:
https://doaj.org/article/25f07ebfc68740c2abd564007d7a6365
Autor:
Hemant Kulkarni, Manju Mamtani, Juan Peralta, Marcio Almeida, Thomas D Dyer, Harald H Goring, Matthew P Johnson, Ravindranath Duggirala, Michael C Mahaney, Rene L Olvera, Laura Almasy, David C Glahn, Sarah Williams-Blangero, Joanne E Curran, John Blangero
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151177 (2016)
While the role of type 2 diabetes (T2D) in inducing endothelial dysfunction is fairly well-established the etiological role of endothelial dysfunction in the onset of T2D is still a matter of debate. In the light of conflicting evidence in this regar
Externí odkaz:
https://doaj.org/article/8f78fe2da821447da3e0cb07443a0562
Autor:
Venkata Saroja eVoruganti, Jack W Kent, Subrata eDebnath, Shelley A Cole, Karin eHaack, Harald HH Goring, Melanie A Carless, Joanne E Curran, Matthew P Johnson, Laura eAlmasy, Thomas D Dyer, Jean W MacCluer, Eric K Moses, Hanna E Abboud, Michael C Mahaney, John eBlangero, Anthony Gean Comuzzie
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Increased serum uric acid (SUA) is a risk factor for gout and renal and cardiovascular disease. The purpose of this study was to identify genetic factors that affect the variation in SUA in 632 Mexican Americans participants of the San Antonio Family
Externí odkaz:
https://doaj.org/article/0ceefc2e4e444682a5ffed233e41c40c
Autor:
Manju Mamtani, Hemant Kulkarni, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, John Blangero, Joanne E Curran
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59153 (2013)
In spite of the growing recognition of the specific association of waist circumference (WC) with type 2 diabetes (T2D) and insulin resistance (IR), current guidelines still use body mass index (BMI) as a tool of choice. Our objective was to determine
Externí odkaz:
https://doaj.org/article/723ee03a56b04afd992161308d0eec90
Autor:
Melanie A Carless, Hemant Kulkarni, Mark Z Kos, Jac Charlesworth, Juan M Peralta, Harald H H Göring, Joanne E Curran, Laura Almasy, Thomas D Dyer, Anthony G Comuzzie, Michael C Mahaney, John Blangero
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73950 (2013)
Several studies have identified effects of genetic variation on DNA methylation patterns and associated heritability, with research primarily focused on Caucasian individuals. In this paper, we examine the evidence for genetic effects on DNA methylat
Externí odkaz:
https://doaj.org/article/58b965aa90ac448085f1100a57d42f75
Autor:
Peter J Meikle, Gerard Wong, Christopher K Barlow, Jacquelyn M Weir, Melissa A Greeve, Gemma L MacIntosh, Laura Almasy, Anthony G Comuzzie, Michael C Mahaney, Adam Kowalczyk, Izhac Haviv, Narelle Grantham, Dianna J Magliano, Jeremy B M Jowett, Paul Zimmet, Joanne E Curran, John Blangero, Jonathan Shaw
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74341 (2013)
The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly defined. We hypothesized that a lipidomic analysis of plasma lipids might improve the understa
Externí odkaz:
https://doaj.org/article/856340692ae64f699386a345f52d7cc9
Autor:
Vincent P. Diego, Eron G. Manusov, Xi Mao, Marcio Almeida, Juan M. Peralta, Joanne E. Curran, Michael C. Mahaney, Harald Göring, John Blangero, Sarah Williams-Blangero
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background: Socioeconomic Status (SES) is a potent environmental determinant of health. To our knowledge, no assessment of genotype-environment interaction has been conducted to consider the joint effects of socioeconomic status and genetics on risk
Externí odkaz:
https://doaj.org/article/37f1a4f6dab94266a5fe3f973d126ef2
Autor:
Bernard Fongang, Claudia Satizabal, Tiffany F. Kautz, Yannick N. Wadop, Jazmyn A. S. Muhammad, Erin Vasquez, Julia Mathews, Monica Gireud-Goss, Amy R. Saklad, Jayandra Himali, Alexa Beiser, Jose E. Cavazos, Michael C. Mahaney, Gladys Maestre, Charles DeCarli, Eric L. Shipp, Ramachandran S. Vasan, Sudha Seshadri
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract A bidirectional communication exists between the brain and the gut, in which the gut microbiota influences cognitive function and vice-versa. Gut dysbiosis has been linked to several diseases, including Alzheimer's disease and related dement
Externí odkaz:
https://doaj.org/article/6cd56d8bd3934f04aeef2cc00faa8818
Autor:
Vincent P. Diego, Eron G. Manusov, Xi Mao, Joanne E. Curran, Harald Göring, Marcio Almeida, Michael C. Mahaney, Juan M. Peralta, John Blangero, Sarah Williams-Blangero
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Socioeconomic status (SES) is a potent environmental determinant of health. To our knowledge, no assessment of genotype-environment interaction has been conducted to consider the joint effects of socioeconomic status and genetics on risk
Externí odkaz:
https://doaj.org/article/cb8641bc99dc4cb4bea6f454655a0072