Zobrazeno 1 - 10
of 531
pro vyhledávání: '"Michael C Jensen"'
Autor:
Michael C Jensen, Venu G Pillarisetty, Katherine J Brempelis, Courtney M Cowan, Shannon A Kreuser, Kevin P Labadie, Brooke M Prieskorn, Nicole A P Lieberman, Chibawanye I Ene, Kara W Moyes, Harrison Chinn, Kole R DeGolier, Lisa R Matsumoto, Sara K Daniel, Jason K Yokoyama, Amira D Davis, Virginia J Hoglund, Kimberly S Smythe, Stephanie D Balcaitis, Richard G Ellenbogen, Jean S Campbell, Robert H Pierce, Eric C Holland, Courtney A Crane
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Though currently approved immunotherapies, including chimeric antigen receptor T cells and checkpoint blockade antibodies, have been successfully used to treat hematological and some solid tumor cancers, many solid tumors remain resistant
Externí odkaz:
https://doaj.org/article/c3322864d2c54a13b3b2a3dea90a8cdb
Autor:
Alexandra E Grier, Stephen Burleigh, Jaya Sahni, Courtnee A Clough, Victoire Cardot, Dongwook C Choe, Michelle C Krutein, David J Rawlings, Michael C Jensen, Andrew M Scharenberg, Kyle Jacoby
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Increasing demand for large-scale synthesis of in vitro transcribed (IVT) mRNA is being driven by the increasing use of mRNA for transient gene expression in cell engineering and therapeutic applications. An important determinant of IVT mRNA potency
Externí odkaz:
https://doaj.org/article/0765478c45c24feb9f2d7d51e87d648f
Autor:
Hao Hong, Christine E Brown, Julie R Ostberg, Saul J Priceman, Wen-Chung Chang, Lihong Weng, Paul Lin, Mark T Wakabayashi, Michael C Jensen, Stephen J Forman
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146885 (2016)
New therapeutic modalities are needed for ovarian cancer, the most lethal gynecologic malignancy. Recent clinical trials have demonstrated the impressive therapeutic potential of adoptive therapy using chimeric antigen receptor (CAR)-redirected T cel
Externí odkaz:
https://doaj.org/article/4f40deaae4fd4076bfa005174c5c01a3
Autor:
Vaidehi Mahadev, Renate Starr, Sarah L Wright, Catalina Martinez, Michael C Jensen, Michael E Barish, Stephen J Forman, Christine E Brown
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95123 (2014)
The interleukin-13 receptor alpha2 (IL13Rα2) is a cell surface receptor that is over-expressed by a subset of high-grade gliomas, but not expressed at significant levels by normal brain tissue. For both malignant and non-malignant cells, IL13Rα2 su
Externí odkaz:
https://doaj.org/article/422c926d34fd4beca52ad18d24b91b1b
Autor:
Mahesh Jonnalagadda, Christine E Brown, Wen-Chung Chang, Julie R Ostberg, Stephen J Forman, Michael C Jensen
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65519 (2013)
Gene transfer and drug selection systems that enforce ongoing transgene expression in vitro and in vivo which are compatible with human pharmaceutical drugs are currently underdeveloped. Here, we report on the utility of incorporating human enzyme mu
Externí odkaz:
https://doaj.org/article/f2442a07bd544b1599f18f1a8eeed631
Autor:
Lihua E Budde, Carolina Berger, Yukang Lin, Jinjuan Wang, Xubin Lin, Shani E Frayo, Shaunda A Brouns, David M Spencer, Brian G Till, Michael C Jensen, Stanley R Riddell, Oliver W Press
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82742 (2013)
Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cell
Externí odkaz:
https://doaj.org/article/9ca938c0d3a749a2982d8ec6151cbcd1
Autor:
Zhaoxia Zou, Erin Denny, Christine E Brown, Michael C Jensen, Gang Li, Tatsuhiro Fujii, Josh Neman, Rahul Jandial, Mike Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34652 (2012)
Cell-based therapies have intriguing potential for the treatment of a variety of neurological disorders. One such example is genetically engineered cytotoxic T lymphocytes (CTLs) that are being investigated in brain tumor clinical trials. The develop
Externí odkaz:
https://doaj.org/article/d841bb3b2c7340a0866fe317f2b26d48
Autor:
Nicholas A. Vitanza, Rebecca Ronsley, Michelle Choe, Casey Henson, Mandy Breedt, Adriel Barrios-Anderson, Amy Wein, Christopher Brown, Adam Beebe, Ada Kong, Danielle Kirkey, Brittany M. Lee, Sarah E.S. Leary, Erin E. Crotty, Corrine Hoeppner, Susan Holtzclaw, Ashley L. Wilson, Joshua A. Gustafson, Jessica B. Foster, Jeffrey J. Iliff, Hannah E. Goldstein, Samuel R. Browd, Amy Lee, Jeffrey G. Ojemann, Navin Pinto, Juliane Gust, Rebecca A. Gardner, Michael C. Jensen, Jason S. Hauptman, Julie R. Park
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 36, Iss , Pp 100870- (2023)
Central nervous system (CNS) tumors are the most common solid malignancy in the pediatric population. Based on adoptive cellular therapy's clinical success against childhood leukemia and the preclinical efficacy against pediatric CNS tumors, chimeric
Externí odkaz:
https://doaj.org/article/0dd9cbf684b44b109bab4c85d507e99f
Autor:
Sara Bolivar-Wagers, Michael L. Loschi, Sujeong Jin, Govindarajan Thangavelu, Jemma H. Larson, Cameron S. McDonald-Hyman, Ethan G. Aguilar, Asim Saha, Brent H. Koehn, Mehrdad Hefazi, Mark J. Osborn, Michael C. Jensen, John E. Wagner, Christopher A. Pennell, Bruce R. Blazar
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and mortality. Regulatory T cells (Tregs) have shown efficacy in preventing GVHD. However, high T
Externí odkaz:
https://doaj.org/article/13f49ac28e6643b598a93fee5b351f8a
Autor:
Solin Ali, Karin Toews, Silke Schwiebert, Anika Klaus, Annika Winkler, Laura Grunewald, Lena Oevermann, Hedwig E. Deubzer, Alicia Tüns, Michael C. Jensen, Anton G. Henssen, Angelika Eggert, Johannes H. Schulte, Esther Schwich, Vera Rebmann, Alexander Schramm, Annette Künkele
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived extracellular vesicles. Advanced neuroblastoma is an aggressive childhood tumor without cur
Externí odkaz:
https://doaj.org/article/08d9b061f34547348113e50ddc8b2d15