Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Michael C, Chang"'
Publikováno v:
Ophthalmology Science, Vol 3, Iss 4, Pp 100301- (2023)
Purpose: To investigate the relationship between complement pathway activities and progression of geographic atrophy (GA) secondary to age-related macular degeneration in samples collected from patients enrolled in the Chroma and Spectri trials. Desi
Externí odkaz:
https://doaj.org/article/870ab318f19d404c9039bbeb0e5c46d3
Publikováno v:
Ophthalmology Science, Vol 3, Iss 3, Pp 100286- (2023)
Purpose: Lampalizumab, an antigen-binding fragment of a humanized monoclonal antibody directed against complement factor D (CFD), is designed to treat geographic atrophy (GA) secondary to age-related macular degeneration. Given the lack of clinical e
Externí odkaz:
https://doaj.org/article/77ee63aa587c4d2c901652e1beaa3098
Autor:
Amy D Stockwell, Michael C Chang, Anubha Mahajan, William Forrest, Neha Anegondi, Rion K Pendergrass, Suresh Selvaraj, Jens Reeder, Eric Wei, Victor A Iglesias, Natalie M Creps, Laura Macri, Andrea N Neeranjan, Marcel P van der Brug, Suzie J Scales, Mark I McCarthy, Brian L Yaspan
Publikováno v:
PLoS Genetics, Vol 19, Iss 8, p e1010609 (2023)
Diabetic retinopathy (DR) is a common complication of diabetes. Approximately 20% of DR patients have diabetic macular edema (DME) characterized by fluid leakage into the retina. There is a genetic component to DR and DME risk, but few replicable loc
Externí odkaz:
https://doaj.org/article/5e260e67982f45a2b7579ec2725cc7d5
Autor:
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D. Gandham, Christopher M. Rose, Corey E. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C. Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Nature Aging. 2:837-850
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3123df57638f9af969ca987e8610231
https://doi.org/10.1038/s43587-022-00281-1
https://doi.org/10.1038/s43587-022-00281-1
Autor:
Tiffany Wu, Borislav Dejanovic, Vineela D. Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H. Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael C. Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2111-2123.e6 (2019)
Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focuse
Externí odkaz:
https://doaj.org/article/6cf938f6916a4deca5b7f57d27bda622
Autor:
Amy D. Stockwell, Michael C. Chang, Anubha Mahajan, William Forrest, Neha Anegondi, RK Pendergrass, Suresh Selvaraj, Jens Reeder, Eric Wei, VA Iglesias, Natalie M. Creps, Laura Macri, Andrea N. Neeranjan, Marcel P. van der Brug, Suzie J. Scales, Mark I. McCarthy, Brian L. Yaspan
Diabetic retinopathy (DR) is a common complication of diabetes. Approximately 20% of DR patients have diabetic macular edema (DME) characterized by fluid leakage into the retina. There is a genetic component to DR and DME risk, but few replicable loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb3ff389d22db988becdb2b05d2b51c
https://doi.org/10.1101/2023.01.23.23284446
https://doi.org/10.1101/2023.01.23.23284446
Autor:
Michael C. Chang, Caitlin M. Griffin, Elizabeth Palavecino, Andrew M. Nunn, Amy N. Hildreth, Preston R. Miller, Martin Avery, Ashlee E Stutsrim
Publikováno v:
The American Surgeon. 87:765-770
Background Deranged physiology in trauma complicates the clinical identification of sepsis, resulting in overscreening for bacteremia. No clinical signs or biomarkers accurately diagnose sepsis in this population. Our objective was to evaluate the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3a3802db80b0c86a286fcd59bf8ec3
https://doi.org/10.1177/0003134820954786
https://doi.org/10.1177/0003134820954786
Autor:
Michael C. Chang, David A. Masneri, Andrea M. Long, Nathan T. Mowery, Jeffrey E Carter, Cedric M. Lefebvre, James E. Johnson
Publikováno v:
Journal of Surgical Education. 76:1116-1121
Every trauma patient has a golden hour, and resuscitation efficiency within that hour has large implications for patients. We instituted simulation based trauma resuscitation training with the hypothesis that it would improve trauma team efficiency.F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bfbe785cb254ebdcf57b9b4e8457e2
https://doi.org/10.1016/j.jsurg.2019.01.003
https://doi.org/10.1016/j.jsurg.2019.01.003
Autor:
Miguel A, Contreras, Matthew E, Arnegard, Michael C, Chang, Sheri, Hild, Franziska, Grieder, Stephanie J, Murphy
Publikováno v:
Lab animal. 50(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7072693b75c667ac53df671a570ef38b
https://pubmed.ncbi.nlm.nih.gov/34163043
https://pubmed.ncbi.nlm.nih.gov/34163043
Publikováno v:
Lab animal. 50(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a06e2d0339417fbd72f04a02c2789248
https://pubmed.ncbi.nlm.nih.gov/33927412
https://pubmed.ncbi.nlm.nih.gov/33927412