Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Michael C, Carroll"'
Autor:
Cecilia Fahlquist-Hagert, Thomas R. Wittenborn, Ewa Terczyńska-Dyla, Kristian Savstrup Kastberg, Emily Yang, Alysa Nicole Rallistan, Quinton Raymond Markett, Gudrun Winther, Sofie Fonager, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, Alexey Ferapontov, Lisbeth Jensen, Jinrong Huang, John D. Nieland, Cees E. van der Poel, Johan Palmfeldt, Michael C. Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Søren E. Degn
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus eryth
Externí odkaz:
https://doaj.org/article/77b3e9364b6c4ef5993ede3e01fc8946
Autor:
Carlos Castrillon, Lea Simoni, Theo van den Broek, Cees van der Poel, Elliot H Akama-Garren, Minghe Ma, Michael C Carroll
Publikováno v:
eLife, Vol 12 (2023)
Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here, we used fate-mapping reporter mice and single-cell transcriptomics coupled to antibody repertoire analysis to characterize the post-ger
Externí odkaz:
https://doaj.org/article/89c2971e118943a3a05cb88795fde559
Autor:
Theo van den Broek, Lea Simoni, Michael C Carroll, Carlos Castrillon, Cees van der Poel, Elliot H Akama-Garren, Minghe Ma
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/f2b81ec89c24485d8305f2e733435e94
Autor:
Elliot H. Akama-Garren, Theo van den Broek, Lea Simoni, Carlos Castrillon, Cees E. van der Poel, Michael C. Carroll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease are unclear. Using a mouse model of autoantibody disease, the authors show that autoimmune follicular T cells differ by TCR clonotype and transcriptiona
Externí odkaz:
https://doaj.org/article/c9345cccdb824c95b00d246c802d8ab3
Autor:
Lea Simoni, Michael C Carroll, Carlos Castrillon, Theo van den Broek, Cees van der Poel, Elliot Akama-Garren
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/47615933987843e881dbe1ce1630770b
Autor:
Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108330- (2020)
Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact. Despite being 99% homologo
Externí odkaz:
https://doaj.org/article/c48ff8f821164560853c32065663b406
Autor:
Nikolaos Chatziandreou, Yagmur Farsakoglu, Miguel Palomino-Segura, Rocco D’Antuono, Diego Ulisse Pizzagalli, Federica Sallusto, Veronika Lukacs-Kornek, Mariagrazia Uguccioni, Davide Corti, Shannon J. Turley, Antonio Lanzavecchia, Michael C. Carroll, Santiago F. Gonzalez
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2427-2440 (2017)
The mechanism by which inflammation influences the adaptive response to vaccines is not fully understood. Here, we examine the role of lymph node macrophages (LNMs) in the induction of the cytokine storm triggered by inactivated influenza virus vacci
Externí odkaz:
https://doaj.org/article/934b53f8cf8d45b48b75e2ddcf954ded
Autor:
Cees E. van der Poel, Goran Bajic, Charles W. Macaulay, Theo van den Broek, Christian D. Ellson, Gerben Bouma, Gabriel D. Victora, Søren E. Degn, Michael C. Carroll
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2745-2755.e4 (2019)
Summary: Follicular dendritic cells (FDCs), a rare and enigmatic stromal cell type in the B cell follicles of secondary lymphoid organs, store and present antigen to B cells. While essential for germinal center (GC) responses, their exact role during
Externí odkaz:
https://doaj.org/article/808ea57c369d473fa9c886315dd46bd7
Autor:
Ninghai Wang, Burcu Yigit, Cees E. van der Poel, Marta Cuenca, Michael C. Carroll, Roland W. Herzog, Pablo Engel, Cox Terhorst
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Absence of the mouse cell surface receptor SLAMF3 in SLAMF3-/- mice suggested that this receptor negatively regulates B cell homeostasis by modulating activation thresholds of B cell subsets. Here, we examine whether anti-SLAMF3 affects both B and T
Externí odkaz:
https://doaj.org/article/811386da510c435a8526b971e3313917
Autor:
Ernest Aw, Stacie L. Lin, Yingying Zhang, Uli Herrmann, Esra Yalcin, Kent Langston, Carlos Castrillion, Minghe Ma, Jeffrey R. Moffitt, Michael C. Carroll
Publikováno v:
bioRxiv
Among systemic lupus erythematosus (SLE) patients, neuropsychiatric symptoms are highly prevalent, being observed in up to 80% of adult and 95% of pediatric patients. Type 1 interferons, particularly interferon alpha (IFNα), have been implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1be7f9fa316b946bc54fe520424e2fd
https://europepmc.org/articles/PMC10153248/
https://europepmc.org/articles/PMC10153248/
