Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Michael Buszczak"'
Autor:
M. Carmen Lafita-Navarro, Yi-Heng Hao, Chunhui Jiang, Seoyeon Jang, Tsung-Cheng Chang, Isabella N. Brown, Niranjan Venkateswaran, Elizabeth Maurais, Weronika Stachera, Yanfeng Zhang, Dorothy Mundy, Jungsoo Han, Vanna M. Tran, Marcel Mettlen, Lin Xu, Jeffrey B. Woodruff, Nick V. Grishin, Lisa Kinch, Joshua T. Mendell, Michael Buszczak, Maralice Conacci-Sorrell
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113280- (2023)
Summary: Increased nucleolar size and activity correlate with aberrant ribosome biogenesis and enhanced translation in cancer cells. One of the first and rate-limiting steps in translation is the interaction of the 40S small ribosome subunit with mRN
Externí odkaz:
https://doaj.org/article/c9443ad8099941449a8b52f34efe5875
Autor:
Maikke B. Ohlson, Jennifer L. Eitson, Alexandra I. Wells, Ashwani Kumar, Seoyeon Jang, Chunyang Ni, Chao Xing, Michael Buszczak, John W. Schoggins
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Viruses are known to co-opt host machinery for translation initiation, but less is known about which host factors are required for the formation of ribosomes used to synthesize viral proteins. Using a loss-of-function CRISPR screen, we show
Externí odkaz:
https://doaj.org/article/283e63e8f9ab43d9898e630d22d7fa87
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The regulation of mRNA translation, both globally and at the level of individual transcripts, plays a central role in the development and function of germ cells across species. Genetic studies using flies, worms, zebrafish and mice have highlighted t
Externí odkaz:
https://doaj.org/article/28ffa60c269b48e091fadef7b3af01a7
Autor:
Jiawei Zhao, Eunice E. Lee, Jiwoong Kim, Rong Yang, Bahir Chamseddin, Chunyang Ni, Elona Gusho, Yang Xie, Cheng-Ming Chiang, Michael Buszczak, Xiaowei Zhan, Laimonis Laimins, Richard C. Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The authors identify circular RNAs (circRNA) from human papillomavirus and show that circRNA-encoded E7 contributes to cancer cell growth in vitro and in tumor xenografts. Furthermore, circE7 is present in TCGA RNA-Seq data from HPV-positive cancers.
Externí odkaz:
https://doaj.org/article/d6e2d14d8afd4ed6b39081f56f70355c
Autor:
Jiawei Zhao, Eunice E. Lee, Jiwoong Kim, Rong Yang, Bahir Chamseddin, Chunyang Ni, Elona Gusho, Yang Xie, Cheng-Ming Chiang, Michael Buszczak, Xiaowei Zhan, Laimonis Laimins, Richard C. Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5e83d9eeee35497b95559942cd4d7f92
Autor:
M Carmen Lafita-Navarro, Niranjan Venkateswaran, Jessica A Kilgore, Suman Kanji, Jungsoo Han, Spencer Barnes, Noelle S Williams, Michael Buszczak, Sandeep Burma, Maralice Conacci-Sorrell
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009117 (2020)
Glioblastoma is the most common and aggressive type of cancer in the brain; its poor prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent temozolomide, which is triggered by an increase in the expression of DNA re
Externí odkaz:
https://doaj.org/article/b18a09d25d7e4899a2e3c4dfd0fa497b
Autor:
Nevine A. Shalaby, Raheel Sayed, Qiao Zhang, Shane Scoggin, Susan Eliazer, Adrian Rothenfluh, Michael Buszczak
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Jumonji (JmjC) domain proteins influence gene expression and chromatin organization by way of histone demethylation, which provides a means to regulate the activity of genes across the genome. JmjC proteins have been associated with many hum
Externí odkaz:
https://doaj.org/article/47ad0110818946e8ae66ce69c73acfe1
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 12, Pp 3849-3857 (2016)
Conserved from yeast to humans, the Paf1 complex participates in a number of diverse processes including transcriptional initiation and polyadenylation. This complex typically includes five proteins: Paf1, Rtf1, Cdc73, Leo1, and Ctr9. Previous effort
Externí odkaz:
https://doaj.org/article/c278627a9c6c408b959a5556abbe9ab7
Autor:
Susan Eliazer, Victor Palacios, Zhaohui Wang, Rahul K Kollipara, Ralf Kittler, Michael Buszczak
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004200 (2014)
Specialized microenvironments called niches regulate tissue homeostasis by controlling the balance between stem cell self-renewal and the differentiation of stem cell daughters. However the mechanisms that govern the formation, size and signaling of
Externí odkaz:
https://doaj.org/article/bd29e973622a4faa83e36fa4cb762411
Publikováno v:
eLife, Vol 3 (2014)
Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after exp
Externí odkaz:
https://doaj.org/article/445c198180f242328a0b01b4cb990620