Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Michael Bubser"'
Autor:
Richard M. Gustin, Terry Jo Bichell, Michael Bubser, Jennifer Daily, Irina Filonova, Davit Mrelashvili, Ariel Y. Deutch, Roger J. Colbran, Edwin J. Weeber, Kevin F. Haas
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 283-291 (2010)
Angelman syndrome (AS) is a neurogenetic disorder caused by loss of maternal UBE3A expression or mutation-induced dysfunction of its protein product, the E3 ubiquitin–protein ligase, UBE3A. In humans and rodents, UBE3A/Ube3a transcript is maternall
Externí odkaz:
https://doaj.org/article/a3facd51343c42d4bb123b0d1c26e81d
Publikováno v:
Advances in Neurobiology ISBN: 9783031210532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf03c4d5f8026846613830ce2d6e3bb
https://doi.org/10.1007/978-3-031-21054-9_3
https://doi.org/10.1007/978-3-031-21054-9_3
Autor:
Jason K Russell, Michael Bubser, Shalonda Ingram, Paul A Newhouse, Craig W Lindsley, Carrie K Jones
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Laura B. Teal, Michael Bubser, Edith Duncan, Robert W. Gould, Craig W. Lindsley, Carrie K. Jones
Publikováno v:
Neuropharmacology. 227:109424
Autor:
Aaron T, Garrison, Douglas L, Orsi, Rory A, Capstick, David, Whomble, Jinming, Li, Trever R, Carter, Andrew S, Felts, Paige N, Vinson, Alice L, Rodriguez, Allie, Han, Krishma, Hajari, Hyekyung P, Cho, Laura B, Teal, Madeline G, Ragland, Masoud, Ghamari-Langroudi, Michael, Bubser, Sichen, Chang, Nathalie C, Schnetz-Boutaud, Olivier, Boutaud, Anna L, Blobaum, Daniel J, Foster, Colleen M, Niswender, P Jeffrey, Conn, Craig W, Lindsley, Carrie K, Jones, Changho, Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
The muscarinic acetylcholine receptor (mAChR) subtype 5 (M
Autor:
Anna L. Blobaum, Thomas M. Bridges, Paul A. Newhouse, Robert W. Gould, Michael Bubser, Michael T. Nedelcovych, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Jason K Russell, Michael A. Nader
Publikováno v:
Neuropsychopharmacology. 45:2219-2228
Degeneration of basal forebrain cholinergic circuitry represents an early event in the development of Alzheimer's disease (AD). These alterations in central cholinergic function are associated with disruptions in arousal, sleep/wake architecture, and
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Changho Han, J. Scott Daniels, Alice L. Rodriguez, Colleen M. Niswender, Alison R. Gregro, P. Jeffrey Conn, Michael R. Wood, Craig W. Lindsley, Katrina A. Bollinger, Michael W. Wood, Mark E. Duggan, Sichen Chang, Darren W. Engers, Atin Lamsal, Ryan D. Morrison, Andrew S. Felts, Trevor C. Chopko, Nicholas J. Brandon, Nathalie Schnetz-Boutaud, Vincent B. Luscombe, Hyekyung P. Cho, Mike Poslusney, Carrie K. Jones, Donald F. Stec, Thomas M. Bridges, Michael Bubser, Bruce J. Melancon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2224-2228
This letter describes progress towards an M4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant thieno[2,3-c]pyridine core to an equipotent, non-CNS penetrant thieno[2,3-c]pyrdin-7(6H)-one c
Autor:
Laura B. Teal, Robert W. Gould, Michael Bubser, Robert T. Matthews, Danny G. Winder, Aaron T. Garrison, Madeline G. Ragland, Thomas M. Bridges, Craig W. Lindsley, Carrie K. Jones, Barak W. Gunter
Publikováno v:
ACS Chemical Neuroscience. 10:3740-3750
Opioid use disorder (OUD) is a debilitating neuropsychiatric condition characterized by compulsive opioid use, dependence, and repeated relapse after periods of abstinence. Given the high risk of d...
Autor:
Alice L. Rodriguez, P. Jeffrey Conn, Allison R. Gregro, Michael Bubser, Mark E. Dugan, Colleen M. Niswender, Leah C. Konkol, Michael W. Wood, Darren W. Engers, Craig W. Lindsley, Jeanette L. Bertron, Bruce J. Melancon, Sean R. Bollinger, Thomas M. Bridges, Samantha E. Yohn, Vincent B. Luscombe, Andrew S. Felts, Michael R. Wood, Carrie K. Jones, Nicholas J. Brandon, Katrina A. Bollinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1714-1718
This letter describes progress towards an M4 PAM preclinical candidate that resulted in the discovery of VU6005806/AZN-00016130. While the thieno[2,3-c]pyridazine core has been a consistent feature of key M4 PAMs, no work had previously been reported