Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael Brunavs"'
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Over 90% of marketed drugs are small molecules, low molecular weight organic compounds that have been discovered, designed, and developed to prompt a specific biological process in the body. Examples include antibiotics (penicillin), analgesics (para
Externí odkaz:
https://doaj.org/article/f31fa8230d5c439ca618a62ea3397293
Publikováno v:
ACS Medicinal Chemistry Letters
Biochemical assay interference is becoming increasingly recognized as a significant waste of resource in drug discovery, both in industry and academia. A seminal publication from Baell and Holloway raised the awareness of this issue, and they publish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4e0c4a53e53f16818111b29f4e548f
https://doi.org/10.1021/acsmedchemlett.8b00097
https://doi.org/10.1021/acsmedchemlett.8b00097
Publikováno v:
Organic Letters. 18:1562-1565
The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onwards to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a061434e298b57f039f4738c19600df0
https://doi.org/10.1021/acs.orglett.6b00390
https://doi.org/10.1021/acs.orglett.6b00390
Publikováno v:
ChemInform. 47
The Rhodium-catalyzed reaction of 2-alkynyl anilines with aryl, hetaryl or alkyl aldehydes leads to 2-aminophenyl enones which are further transformed into substituted quinolines endowed with diverse functional groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf6b0a966c020365a282d87f59e16dc
https://doi.org/10.1002/chin.201635124
https://doi.org/10.1002/chin.201635124
Autor:
Mark Wakulchik, Michael J. Krambis, Louis Scampavia, Rok Cerne, Michael Brunavs, Peter Chase, Jeremy Findlay, Maria Cuadrado, Emery Smith, Timothy P. Spicer, Enrique Jambrina, Daniel Ursu, Peter Thaddeus Gallagher, Kevin D. Burris
Publikováno v:
Journal of biomolecular screening. 21(5)
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that play an important role in synaptic plasticity and learning and memory formation. Malfunctioning of NMDARs, in particular the reduction in NMDAR activity, is thought to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639b5068f899164ad90389b24c670762
https://pubmed.ncbi.nlm.nih.gov/26838761
https://pubmed.ncbi.nlm.nih.gov/26838761
Autor:
Kelly A. Halliday, Smith Colin William, Rosemarie Tomlinson, W. Martin Owton, Michael Brunavs, David R. Dobson, Stephen L. Carney, Miles Martin Victor, Richard J. Broadmore, Samantha J. Ambler, Ann E. Kingston, David J. Steggles, Peter Thaddeus Gallagher, T. A. Hicks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:817-822
Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of antrhaquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c3b528cf07f09d355047545625fb3fe
https://doi.org/10.1016/s0960-894x(97)00102-9
https://doi.org/10.1016/s0960-894x(97)00102-9
Publikováno v:
Organic Letters. 18:2519-2519
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c3e4d7daebfce26f3aac09a46318fc
https://doi.org/10.1021/acs.orglett.6b01218
https://doi.org/10.1021/acs.orglett.6b01218
Autor:
William Martin Owton, Michael Brunavs
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4d8eeaab205a93d1fcb6d0dfa3a42d
https://doi.org/10.1002/chin.199218158
https://doi.org/10.1002/chin.199218158
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8c79ec7dfe9168044c5637e82b85de3
https://doi.org/10.1002/chin.199225174
https://doi.org/10.1002/chin.199225174
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::879814b4ec14f37163eb3d248f3484d8
https://doi.org/10.1002/chin.199501128
https://doi.org/10.1002/chin.199501128