Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael Breslav"'
Autor:
Fred Naider, Jeffrey M. Becker, Angela Mckinney, Ying Jiang, Michael Breslav, Ram Kumar Khare
Publikováno v:
International Journal of Peptide and Protein Research. 45:106-115
Analogues of alpha-factor, Saccharomyces cerevisiae tridecapeptide mating pheromone (H-Trp-His-Trp-Leu-Gln-Leu-Lys-Pro-Gly-Gln-Pro-Met-Tyr-OH), containing both p-benzoyl phenylalanine (Bpa), a photoactivatable group, and 3-(mono- or di-iodo-4-hydroxy
Autor:
Birdella D. Kenney, Cynthia A. Maryanoff, John E. Mills, Bruce D. Harris, Rosie Chang, Roland Glaser, Frank J. Villani, Armin Roessler, Michael Breslav, Brigitte E. Segmuller
Publikováno v:
The Journal of Organic Chemistry. 72:9798-9801
An efficient process to produce kilogram quantities of a key argininylbenzo[d]thiazole intermediate was developed for the preparation of the tryptase inhibitor RWJ-56423. A variety of activated arginine esters and benzo[d]thiazole nucleophiles were e
Publikováno v:
Tetrahedron Letters. 48:3069-3072
A one-pot sequential process consisting of nucleophilic substitution of the lithiated acetylides with Weinreb amides followed by a Michael reaction of the extruded N -methoxy- N -methylamine after quenching with saturated NH 4 Cl, provided β-enamino
Autor:
Aaron Burchfield, Fred Naider, Mark A. Lubkowitz, Michael Breslav, David Barnes, Jeffrey M. Becker
Publikováno v:
Molecular Microbiology. 28:729-741
Summary We have recently cloned an oligopeptide transport gene from Candida albicans denoted OPT1. This gene showed significant sequence similarity to three open reading frames (ORFs) with no previously established function: isp4 from Schizosaccharom
Autor:
Joel R. Garbow, Jeffrey M. Becker, Boris Arshava, Octavian Antohi, Michael Breslav, Fred Naider, Ruth E. Stark
Publikováno v:
Solid State Nuclear Magnetic Resonance. 14:117-136
The utility of rotational echo double resonance (REDOR) NMR spectroscopy for determining the conformations of linear peptides has been examined critically using a series of crystalline and amorphous samples. The focus of the present work was the eval
Publikováno v:
Biopolymers. 46:343-357
Peptides representing both loop and the sixth transmembrane regions of the α-factor receptor of Saccharomyces cerevisiae were synthesized by solid-phase procedures and purified to near homogeneity. CD, nmr, and modeling analysis indicated that in aq
Publikováno v:
Tetrahedron Letters. 38:2219-2222
Acidolytic cleavage of peptides from polymeric supports often employs dithiols as scavengers. A significant impurity was found during the synthesis of peptides containing p-benzoylphenylalanine (Bpa) when 1,2-ethanedithiol was the scavenger. Herein w
Publikováno v:
Microbiology. 143:387-396
A Candida albicans oligopeptide transport gene, OPT1, was cloned from a C. albicans genomic library through heterologous expression in the Saccharomyces cerevisiae di-/tripeptide transport mutant PB1X-9B. When transformed with a plasmid harbouring OP
Publikováno v:
Analytical Biochemistry. 239:213-217
Peptides labeled with radioactive 125 I can be detected at the extremely low concentrations necessary for receptor binding studies and medical applications. Traditional methods of iodination often lead to inactive peptides due to excessive iodination
Publikováno v:
Biochemistry. 33:10094-10099
The solid-state conformation of [Nle12]alpha-factor, the Saccharomyces cerevisiae tridecapeptide mating pheromone (WHWLQLKPGQPNleY), was investigated by 13C,15N rotational-echo double resonance (REDOR) nuclear magnetic resonance spectroscopy (NMR). P