Zobrazeno 1 - 10
of 355
pro vyhledávání: '"Michael Boutros"'
Autor:
Athena Kyrkou, Robert Valla, Yao Zhang, Giulia Ambrosi, Stephanie Laier, Karin Müller-Decker, Michael Boutros, Aurelio A. Teleman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Neurofibromatosis Type II (NFII) is a genetic condition caused by loss of the NF2 gene, resulting in activation of the YAP/TAZ pathway and recurrent Schwann cell tumors, as well as meningiomas and ependymomas. Unfortunately, few pharmacologi
Externí odkaz:
https://doaj.org/article/74c99e061d454d60a7db933eec072acc
Autor:
Adelheid Cerwenka, Tomáš Hofman, Siu Wang Ng, Irene Garcés-Lázaro, Florian Heigwer, Michael Boutros
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Immune checkpoint blockade targeting the adaptive immune system has revolutionized the treatment of cancer. Despite impressive clinical benefits observed, patient subgroups remain non-responsive underscoring the necessity for combinational
Externí odkaz:
https://doaj.org/article/d57e5c9a5f10450d8837917a48b9f12e
Autor:
Michael Baumann, Julio Celis, Ulrik Ringborg, Manuel Heitor, Anton Berns, Tit Albreht, Jeliazko Arabadjiev, Michael Boutros, Mario Brandenburg, Helena Canhao, Fatima Carneiro, Christine Chomienne, Francesco De Lorenzo, Alexander M. M. Eggermont, Angel Font, Elena Garralda, Margarida Goulart, Rui Henrique, Mark Lawler, Lena Maier‐Hein, Francoise Meunier, Simon Oberst, Pedro Oliveira, Maria Papatriantafyllou, Joachim Schüz, Eric Solary, Alfonso Valencia, Rosalia Vargas, Elisabete Weiderpass, Nils Wilking
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 925-945 (2023)
European cancer research stakeholders met in October 2022 in Heidelberg, Germany, at the 5th Gago conference on European Cancer Policy, to discuss the current cancer research and cancer care policy landscape in Europe. Meeting participants highlighte
Externí odkaz:
https://doaj.org/article/15d39edd9240456b9e8cbca1b3a19a7f
Autor:
Damien Markus, Aurore Pelletier, Muriel Boube, Fillip Port, Michael Boutros, François Payre, Benedikt Obermayer, Jennifer Zanet
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1011004 (2023)
The last decade witnesses the emergence of the abundant family of smORF peptides, encoded by small ORF (
Externí odkaz:
https://doaj.org/article/a8eb131da50c42adb79839e9fed578c5
Autor:
Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, Timo Gaiser, Inga Buchholz, Ralf Jesenofsky, Nicolai Härtel, Tianzuo Zhan, Bernd Fischer, Katja Breitkopf-Heinlein, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The heterogeneity underlying cancer organoid phenotypes is not yet well understood. Here, the authors develop an imaging analysis assay for high throughput phenotypic screening of colorectal organoids that allows to define specific morphological chan
Externí odkaz:
https://doaj.org/article/781b445e149e41f2a3b65e3af8beee8f
Autor:
Christopher J. Neufeldt, Berati Cerikan, Mirko Cortese, Jamie Frankish, Ji-Young Lee, Agnieszka Plociennikowska, Florian Heigwer, Vibhu Prasad, Sebastian Joecks, Sandy S. Burkart, David Y. Zander, Baskaran Subramanian, Rayomand Gimi, Seetharamaiyer Padmanabhan, Radhakrishnan Iyer, Mathieu Gendarme, Bachir El Debs, Niels Halama, Uta Merle, Michael Boutros, Marco Binder, Ralf Bartenschlager
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Neufeldt et al. evaluate transcriptional and cytokine secretion profiles of cells and patient sera following SARS-CoV-2 infection and detect distinct upregulation of inflammatory cytokines. They also demonstrate that this upregulation is mediated by
Externí odkaz:
https://doaj.org/article/e74d2975b29b4848bc2c7e84d04fd670
Autor:
Katharina Imkeller, Giulia Ambrosi, Nancy Klemm, Ainara Claveras Cabezudo, Luisa Henkel, Wolfgang Huber, Michael Boutros
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 8, Pp n/a-n/a (2022)
Abstract Wnt pathways are important for the modulation of tissue homeostasis, and their deregulation is linked to cancer development. Canonical Wnt signaling is hyperactivated in many human colorectal cancers due to genetic alterations of the negativ
Externí odkaz:
https://doaj.org/article/544ba03818a64ad99b935e09d2cfae5c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5349 (2023)
Wnt ligands are secreted signaling proteins that display a wide range of biological effects. They play key roles in stimulating Wnt signaling pathways to facilitate processes such as tissue homeostasis and regeneration. Dysregulation of Wnt signaling
Externí odkaz:
https://doaj.org/article/5c927947edb842a2a2450c5f9ac8d606
Autor:
Antonia Schubert, Michael Boutros
Publikováno v:
Molecular Oncology, Vol 15, Iss 1, Pp 3-26 (2021)
In recent years, extracellular vesicles (EVs) emerged as potential diagnostic and prognostic markers for cancer therapy. While the field of EV research is rapidly developing and their application as vehicles for therapeutic cargo is being tested, lit
Externí odkaz:
https://doaj.org/article/270f3b5e2a4e4da28babf47120c274f8
Autor:
Shivohum Bahuguna, Magda Atilano, Marcus Glittenberg, Dohun Lee, Srishti Arora, Lihui Wang, Jun Zhou, Siamak Redhai, Michael Boutros, Petros Ligoxygakis
Publikováno v:
PLoS Genetics, Vol 18, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/f51759f2a8c84a6c990593991d57fff9