Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael Blind"'
Autor:
Michael Blind, Michael Blank
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
Over the last decade, aptamers have begun to find their way from basic research to diverse commercial applications. The development of diagnostics is even more widespread than clinical applications because aptamers do not have to be extensively modif
Externí odkaz:
https://doaj.org/article/58452c11d79446138e37d9e980132214
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie / International edition 54(18), 5369-5373 (2015). doi:10.1002/anie.201409597
Angewandte Chemie / International edition 54(18), 5369-5373 (2015). doi:10.1002/anie.201409597
Cellular behavior is orchestrated by the complex interactions of a myriad of intracellular signal transduction pathways. To understand and investigate the role of individual components in such signaling networks, the availability of specific inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d138105ed400cd4a1fb8cc5356c9fff
https://doi.org/10.1002/anie.201409597
https://doi.org/10.1002/anie.201409597
Autor:
Michael Blank, Michael Blind, Tzuu-Wang Chang, Shuowei Cai, Bal Ram Singh, Pavithra Janardhanan, Charlene M. Mello
Publikováno v:
Biochemical and Biophysical Research Communications. 396:854-860
The category A agent, botulinum neurotoxin (BoNT), is the most toxic molecule known to mankind. The endopeptidase activity of light chain domain of BoNT is the cause for the inhibition of the neurotransmitter release and the flaccid paralysis that le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45816dbbd64c32075e2b093c577d12c
https://doi.org/10.1016/j.bbrc.2010.05.006
https://doi.org/10.1016/j.bbrc.2010.05.006
Autor:
Michael Blind, Beatrix Suess, Wolfgang Hillen, Anke Hunsicker, Johannes Meitert, Günter Mayer, Markus Steber, Marcus Klotzsche, Christian Berens
Publikováno v:
Chemistry & Biology. 16:173-180
SummaryWe identified an RNA aptamer that induces TetR-controlled gene expression in Escherichia coli when expressed in the cell. The aptamer was found by a combined approach of in vitro selection for TetR binding and in vivo screening for TetR induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3346faf68c1245cf3d33f8460029149c
https://doi.org/10.1016/j.chembiol.2008.12.008
https://doi.org/10.1016/j.chembiol.2008.12.008
Autor:
Michael Dabrowski, Michael Blind, Christin Andersson, Eduardo Aneiros, Michael Blank, Johan Mueller, Kristian Sandberg, Eva Nyman, Nancy Dekki Shalaly
Publikováno v:
Journal of Biomolecular Screening
According to the gate control theory of pain, the glycine receptors (GlyRs) are putative targets for development of therapeutic analgesics. A possible approach for novel analgesics is to develop a positive modulator of the glycine-activated Cl(-) cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae080a0372c8afd69d6b43108a7f64b3
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256041
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256041
Autor:
Kerstin Klenzke, Michael Blind, Anja Erpenbach, Frank Schäfer, Peter Porschewski, Mira A.-M. Grättinger
Publikováno v:
SLAS Discovery. 11:773-781
Most applications of xMAP (Luminex) bead-based assay technology in diagnostics and drug discovery use immobilized antigens or antibodies. Here the authors describe the development of novel assay systems in which synthetic oligonucleotides that specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e0f782855ff3f76815d91f4ccc3d8b
https://doi.org/10.1177/1087057106292138
https://doi.org/10.1177/1087057106292138
Autor:
Michael Blind, Michael Blank
Publikováno v:
Current Opinion in Chemical Biology. 9:336-342
Synthetic nucleic acid ligands, called aptamers, bind to protein targets with high specificity and affinity. They are very potent inhibitors of protein function and their application can greatly enhance the process of target validation and drug devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f11838446d52e7be14006c1a8bb451b
https://doi.org/10.1016/j.cbpa.2005.06.011
https://doi.org/10.1016/j.cbpa.2005.06.011
Publikováno v:
ACS chemical biology. 10(1)
Targeting functional, non-catalytic domains of protein kinases or other proteins is an emerging field in chemical biology research. Non-ATP competitive kinase inhibitors allow for the investigation of active-site independent functions, e.g., the biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc453fa5cb293be4368fff4431935cc
https://pubmed.ncbi.nlm.nih.gov/25184543
https://pubmed.ncbi.nlm.nih.gov/25184543
Autor:
Heike Schürer, Günter Mayer, Hans-Heinrich Förster, Peter Welzel, Dietmar Knoll, Michael Blind, Michael Famulok, Ulrich Hahn, Katherina Stembera
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:2557-2563
Nuclease-resistant moenomycin-binding aptamers with dissociation constants in the range of 300 to 400 nM have been selected. Competition experiments have demonstrated that these aptamers recognize a disaccharide analogue of moenomycin. The results of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6226ccbd089d2c7df525dbdc149ade7
https://doi.org/10.1016/s0968-0896(01)00030-x
https://doi.org/10.1016/s0968-0896(01)00030-x
Publikováno v:
Chemistry & Biology. 8(10):931-939
Aptamers are valuable tools for studying numerous aspects of biological processes, opening up new experimental opportunities to analyse the function of a wide range of cellular molecules. Functional RNA molecules can be rapidly selected in vitro from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9492c92907afbf90d57fec9c456ddb13