Výsledky vyhledávání - "Michael Blaesse"

Akademický článek

Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator

Autor: Tomoe Kitao, Francois Lepine, Seda Babloudi, Frederick Walte, Stefan Steinbacher, Klaus Maskos, Michael Blaesse, Michele Negri, Michael Pucci, Bob Zahler, Antonio Felici, Laurence G. Rahme

Publikováno v: mBio, Vol 9, Iss 1 (2018)

ABSTRACT New approaches to antimicrobial drug discovery are urgently needed to combat intractable infections caused by multidrug-resistant (MDR) bacteria. Multiple virulence factor regulator (MvfR or PqsR), a Pseudomonas aeruginosa quorum sensing tra

Externí odkaz: https://doaj.org/article/3a5377cb41f442beb617a5562a681113

Zobrazit plný text záznamu

Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density

Autor: Mari A. Virtanen, Peter Blaesse, Eva Ruusuvuori, Ville O. Paavilainen, Pirta Hotulainen, Michael Blaesse, Enni Bertling, Laszlo Vutskits, Elena Kremneva, Milla Summanen, Inkeri Spoljaric, Patricia Seja, Kai Kaila, Gergana Gateva, Pavel Uvarov

Publikováno v: EMBO Reports

Intracellular pH is a potent modulator of neuronal functions. By catalyzing (de)hydration of CO2, intracellular carbonic anhydrase (CAi) isoforms CA2 and CA7 contribute to neuronal pH buffering and dynamics. The presence of two highly active isoforms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a46850e0bed28db4cf6d036356caaf
http://hdl.handle.net/10138/328870

Zobrazit plný text záznamu

Carbonic anhydrase VII regulates dendritic spine morphology and density via actin filament bundling

Autor: Mari A. Virtanen, Kai Kaila, Michael Blaesse, Milla Summanen, Enni Bertling, Eva Ruusuvuori, Inkeri Spoljaric, Peter Blaesse, Pirta Hotulainen, Laszlo Vutskits, Elena Kremneva, Ville O. Paavilainen, Gergana Gateva, Patricia Seja

Intracellular pH is a potent modulator of neuronal functions. By catalyzing (de)hydration of CO2, intracellular carbonic anhydrase (CAi) isoforms CAII and CAVII contribute to neuronal pH buffering and dynamics. The presence of two highly active isofo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c1d86475df5c3017d3a441ec59fe8a
https://doi.org/10.1101/736868

Zobrazit plný text záznamu

Total Synthesis of Covalent Cysteine Protease Inhibitor N-Desmethyl Thalassospiramide C and Crystallographic Evidence for Its Mode of Action

Autor: Jeremy Fournier, Karen Chen, Artur K. Mailyan, Jeffrey J. Jackson, Brad O. Buckman, Kumar Emayan, Shendong Yuan, Ravi Rajagopalan, Shawn Misialek, Marc Adler, Michael Blaesse, Andreas Griessner, Armen Zakarian

Publikováno v: Organic letters. 21(2)

A total synthesis of N-desmethyl thalassospiramide C, a unique strained macrocyclic proteobacterial depsipeptide, enabled a detailed crystallographic study of its covalent complex with cathepsin K, a member of a medicinally important family of cystei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224f7ef009372f080fe122a19b962fd5
https://pubmed.ncbi.nlm.nih.gov/30628449

Zobrazit plný text záznamu

Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors

Autor: Marja Rantanen, Martin Augustin, Goverdhan Reddy Ummenthala, Jarkko Venalainen, Michael Blaesse, Sapan Choudhary, Petteri Rummakko, Tuomo Kalliokoski

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 30:127060

Human kynurenine aminotransferase 2 (KAT2) inhibitors could be potentially used to treat the cognitive deficits associated with bipolar disease and schizophrenia. Although, there has been active drug research activity by several industrial and academ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c8350f2ae014d3144e156b9b3b3986
https://doi.org/10.1016/j.bmcl.2020.127060

Zobrazit plný text záznamu

Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator

Autor: Michele Negri, Tomoe Kitao, Klaus Maskos, Laurence G. Rahme, Michael J. Pucci, Stefan Steinbacher, Frederick Walte, Seda Babloudi, Michael Blaesse, Antonio Felici, François Lépine, Bob Zahler

Publikováno v: mBio, Vol 9, Iss 1, p e02158-17 (2018)
mBio
mBio, American Society for Microbiology, 2018, 9 (1), pp.e02158-17. ⟨10.1128/mBio.02158-17⟩
mBio, Vol 9, Iss 1 (2018)

New approaches to antimicrobial drug discovery are urgently needed to combat intractable infections caused by multidrug-resistant (MDR) bacteria. M ultiple v irulence f actor r egulator (MvfR or PqsR), a Pseudomonas aeruginosa quorum sensing transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad13b3d86e2a22e5037dc6cbc7145a8
https://doi.org/10.1128/mbio.02158-17

Zobrazit plný text záznamu

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

Autor: Daniel Schwarz, Catherine Jorand-Lebrun, Didier M. Roche, Michael Blaesse, Theresa L. Johnson, Birgitta Leuthner, Hugues Lemoine, Ulrich Grädler, Andreas Marx, Gilardone Marine, Frederic Bernard, Xuliang Jiang

Publikováno v: Bioorganic & Medicinal Chemistry Letters

Graphical abstract
Highlights • 6 Cyclophilin D crystal structures with SPR binding confirmed fragment hits having millimolar potencies were discovered. • One fragment was merged with a potent reference Cyclophilin D inhibitor resulting in s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39b84d7ba72ca682baf2492d74d4f0a
http://europepmc.org/articles/PMC7195332

Zobrazit plný text záznamu

The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder

Autor: Lars Neumann, Michael Blaesse, E.V. Schneider, K. Maskos, Jark Böttcher, Robert Huber

Publikováno v: Journal of Molecular Biology. 412:251-266

Cyclin-dependent kinase (CDK) 8 associates with cyclin C (CycC) and belongs to the CDK module of the Mediator of transcription, together with MED12 and MED13. CDK8 is involved in the regulation of mRNA transcription and was identified as a potent onc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5579fce52d6d420bc7686de9151e47f6
https://doi.org/10.1016/j.jmb.2011.07.020

Zobrazit plný text záznamu

Crystal Structure of the Catalytic Domain of Human Atypical Protein Kinase C-iota Reveals Interaction Mode of Phosphorylation Site in Turn Motif

Autor: Christian Benda, Hans Brandstetter, Albrecht Messerschmidt, Milko Velarde, Mathias Bädeker, Michael Blaesse, Anja Jestel, Sofia Macieira, Torsten Neuefeind

Publikováno v: Journal of Molecular Biology. 352:918-931

Atypical protein kinases C (aPKCs) play critical roles in signaling pathways that control cell growth, differentiation and survival. Therefore, they constitute attractive targets for the development of novel therapeutics against cancer. The crystal s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73eff0ab811bfa5637eb9134db8ef266
https://doi.org/10.1016/j.jmb.2005.07.060

Zobrazit plný text záznamu

Structure of MrsD, an FAD-binding protein of the HFCD family

Autor: Thomas Kupke, Stefan Steinbacher, Michael Blaesse, Robert Huber

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 59:1414-1421

MrsD from Bacillus sp. HIL-Y85/54728 is a member of the HFCD (homo-oligomeric flavin-containing Cys decarboxylases) family of flavoproteins and is involved in the biosynthesis of the lantibiotic mersacidin. It catalyses the oxidative decarboxylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99db61134e841b913b226909cca99506
https://doi.org/10.1107/s0907444903011831

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání