Zobrazeno 1 - 10
of 446
pro vyhledávání: '"Michael Bitzer"'
Autor:
Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A. Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Klaus Schulze-Osthoff, Markus Templin, Nisar P. Malek, Antti Poso, Michael Bitzer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Fibroblast growth factor receptor (FGFR)−2 can be inhibited by FGFR-selective or non-selective tyrosine kinase inhibitors (TKIs). Selective TKIs are approved for cholangiocarcinoma (CCA) with FGFR2 fusions; however, their application is li
Externí odkaz:
https://doaj.org/article/4e23905b41b4488d8d1d8c66053fe10f
Autor:
Claudia Tandler, Jonas S. Heitmann, Tanja M. Michel, Maddalena Marconato, Simon U. Jaeger, Christian M. Tegeler, Monika Denk, Marion Richter, Melek Tutku Oezbek, Yacine Maringer, Sarah M. Schroeder, Nicole Schneiderhan-Marra, Karl-Heinz Wiesmüller, Michael Bitzer, Natalia Ruetalo, Michael Schindler, Christoph Meisner, Imma Fischer, Hans-Georg Rammensee, Helmut R. Salih, Juliane S. Walz
Publikováno v:
International Journal of Infectious Diseases, Vol 139, Iss , Pp 69-77 (2024)
Objectives: T cell immunity is key for the control of viral infections including SARS-CoV-2, in particular with regard to immune memory and protection against arising genetic variants. Methods: We recently evaluated a peptide-based SARS-CoV-2 T cell
Externí odkaz:
https://doaj.org/article/c354f5fd26fd421f8230c3f45d62af98
Autor:
Christopher Hackenbruch, Jens Bauer, Jonas S. Heitmann, Yacine Maringer, Annika Nelde, Monika Denk, Lisa Zieschang, Christine Kammer, Birgit Federmann, Susanne Jung, Peter Martus, Nisar P. Malek, Konstantin Nikolaou, Helmut R. Salih, Michael Bitzer, Juliane S. Walz
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The DNAJB1-PRKACA fusion transcript was identified as the oncogenic driver of tumor pathogenesis in fibrolamellar hepatocellular carcinoma (FL-HCC), also known as fibrolamellar carcinoma (FLC), as well as in other tumor entities, thus representing a
Externí odkaz:
https://doaj.org/article/a2dd1647213e47a0b299877dea3ea6f4
Autor:
Susanne Jung, Richard F. Schlenk, Christopher Hackenbruch, Sandra S.L. Roldan Pinzon, Michael Bitzer, Martin Pflügler, Juliane S. Walz, Gundram Jung, Jonas S. Heitmann, Helmut R. Salih
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionColorectal cancer (CRC) is the third most common cancer worldwide in men and women. In the metastasized stage, treatment options and prognosis are limited. To address the high medical need of this patient population, we generated a CD276x
Externí odkaz:
https://doaj.org/article/7f1c1453e6734dea9e21b4666171cfeb
Autor:
Maria Pouyiourou, Bianca N. Kraft, Timothy Wohlfromm, Michael Stahl, Boris Kubuschok, Harald Löffler, Ulrich T. Hacker, Gerdt Hübner, Lena Weiss, Michael Bitzer, Thomas Ernst, Philipp Schütt, Thomas Hielscher, Stefan Delorme, Martina Kirchner, Daniel Kazdal, Markus Ball, Klaus Kluck, Albrecht Stenzinger, Tilmann Bochtler, Alwin Krämer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-based chemotherapy. 10-20% of patients have a high tumor mutational burden (TMB), which predicts response to immunotherapy in many cancer types. In th
Externí odkaz:
https://doaj.org/article/cf29f4d0ded648268fe0196b4aa79152
Autor:
Jens Bauer, Natalie Köhler, Yacine Maringer, Philip Bucher, Tatjana Bilich, Melissa Zwick, Severin Dicks, Annika Nelde, Marissa Dubbelaar, Jonas Scheid, Marcel Wacker, Jonas S. Heitmann, Sarah Schroeder, Jonas Rieth, Monika Denk, Marion Richter, Reinhild Klein, Irina Bonzheim, Julia Luibrand, Ursula Holzer, Martin Ebinger, Ines B. Brecht, Michael Bitzer, Melanie Boerries, Judith Feucht, Helmut R. Salih, Hans-Georg Rammensee, Stephan Hailfinger, Juliane S. Walz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease with limited therapeutic options. Here, the authors identify the DNAJB1-PRKACA protein as a source for immunogenic neoepitopes and
Externí odkaz:
https://doaj.org/article/3a134c49c74b482cbf740f80cccba049
Autor:
Georgy Berezhnoy, Rosi Bissinger, Anna Liu, Claire Cannet, Hartmut Schäfer, Katharina Kienzle, Michael Bitzer, Helene Häberle, Siri Göpel, Christoph Trautwein, Yogesh Singh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundDeep metabolomic, proteomic and immunologic phenotyping of patients suffering from an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have matched a wide diversity of clinical symptoms with potential biomarkers f
Externí odkaz:
https://doaj.org/article/b1db5699b92f44e995fff750384a84cc
Autor:
Daniel Junker, Alex Dulovic, Matthias Becker, Teresa R. Wagner, Philipp D. Kaiser, Bjoern Traenkle, Katharina Kienzle, Stefanie Bunk, Carlotta Struemper, Helene Haeberle, Kristina Schmauder, Natalia Ruetalo, Nisar Malek, Karina Althaus, Michael Koeppen, Ulrich Rothbauer, Juliane S. Walz, Michael Schindler, Michael Bitzer, Siri Göpel, Nicole Schneiderhan-Marra
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract As global vaccination campaigns against SARS-CoV-2 proceed, there is particular interest in the longevity of immune protection, especially with regard to increasingly infectious virus variants. Neutralizing antibodies (Nabs) targeting the re
Externí odkaz:
https://doaj.org/article/65541620e8964ed78cf2db87bc1b9e1e
Autor:
Luis Kuhn Cuellar, Andreas Friedrich, Gisela Gabernet, Luis de la Garza, Sven Fillinger, Adrian Seyboldt, Tobias Koch, Sven zur Oven-Krockhaus, Friederike Wanke, Sandra Richter, Wolfgang M. Thaiss, Marius Horger, Nisar Malek, Klaus Harter, Michael Bitzer, Sven Nahnsen
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background As technical developments in omics and biomedical imaging increase the throughput of data generation in life sciences, the need for information systems capable of managing heterogeneous digital assets is increasing. In particular,
Externí odkaz:
https://doaj.org/article/8099a30aaa70462e98a8dcdcaa428906
Autor:
Laura Uder, Marcel Nachbar, Sarah Butzer, Jessica Boldt, Sabrina Baumeister, Michael Bitzer, Alfred Königsrainer, Thomas Seufferlein, Rüdiger Hoffmann, Sergios Gatidis, Konstantin Nikolaou, Daniel Zips, Daniela Thorwarth, Cihan Gani, Simon Boeke
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
IntroductionStereotactic body radiotherapy (SBRT) is used to treat liver metastases with the intention of ablation. High local control rates were shown. Magnetic resonance imaging guided radiotherapy (MRgRT) provides the opportunity of a marker-less
Externí odkaz:
https://doaj.org/article/4fc3cd3391a1466bbc058b6ad6e5d756