Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michael Bieler"'
Autor:
Wenyang Li, Jennifer Y Chen, Cheng Sun, Robert P Sparks, Lorena Pantano, Raza-Ur Rahman, Sean P Moran, Joshua V Pondick, Rory Kirchner, David Wrobel, Michael Bieler, Achim Sauer, Shannan J Ho Sui, Julia F Doerner, Jörg F Rippmann, Alan C Mullen
Publikováno v:
eLife, Vol 11 (2022)
Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) myofibroblasts are the primary cell type responsible for liv
Externí odkaz:
https://doaj.org/article/cf1c49e456d44880b04f03d69fd37ac5
Publikováno v:
Journal of Chemical Information and Modeling. 62:3942-3947
We present an easy, human-readable line notation to describe even complex peptides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee0fd6e13f3034396207f58a5eb8fc
https://doi.org/10.1021/acs.jcim.2c00703
https://doi.org/10.1021/acs.jcim.2c00703
Autor:
Yang Yang, Daniela M. Santos, Lorena Pantano, Rachel Knipe, Elizabeth Abe, Amanda Logue, Gina Pronzati, Katharine E. Black, Jillian J. Spinney, Francesca Giacona, Michael Bieler, Cedrickx Godbout, Paul Nicklin, David Wyatt, Andrew M. Tager, Peter Seither, Franziska E. Herrmann, Benjamin D. Medoff
Publikováno v:
Am J Respir Cell Mol Biol
Idiopathic pulmonary fibrosis is a progressive lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6fada14bae95a8a79f19d9635326a85
https://doi.org/10.1165/rcmb.2021-0428oc
https://doi.org/10.1165/rcmb.2021-0428oc
Autor:
Wenyang Li, Jennifer Y Chen, Cheng Sun, Robert P Sparks, Lorena Pantano, Raza-Ur Rahman, Sean P Moran, Joshua V Pondick, Rory Kirchner, David Wrobel, Michael Bieler, Achim Sauer, Shannan J Ho Sui, Julia F Doerner, Jörg F Rippmann, Alan C Mullen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d33dd97295a9b2bb9f0b58f0add2c065
https://doi.org/10.7554/elife.74513.sa2
https://doi.org/10.7554/elife.74513.sa2
Autor:
Wenyang Li, Jennifer Y Chen, Cheng Sun, Robert P Sparks, Lorena Pantano, Raza-Ur Rahman, Sean P Moran, Joshua V Pondick, Rory Kirchner, David Wrobel, Michael Bieler, Achim Sauer, Shannan J Ho Sui, Julia F Doerner, Jörg F Rippmann, Alan C Mullen
Publikováno v:
eLife. 11
Chronic liver injury causes fibrosis, characterized by the formation of scar tissue resulting from excessive accumulation of extracellular matrix (ECM) proteins. Hepatic stellate cell (HSC) myofibroblasts are the primary cell type responsible for liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ecf1f72ecc2d091f60497ebb7d2b78
https://pubmed.ncbi.nlm.nih.gov/35617485
https://pubmed.ncbi.nlm.nih.gov/35617485
Autor:
Royale Nichols, Jillian J Spinney, Michael Bieler, Katharine E. Black, Yufei Lin, Lida P. Hariri, Clemens K. Probst, Paul Nicklin, Benjamin D. Medoff, Lorena Pantano, Paula Grasberger, Peter Seither, David Wyatt, Daniela M. Santos, Gina Pronzati, Andrew M. Tager
Publikováno v:
Am J Respir Cell Mol Biol
Idiopathic pulmonary fibrosis is a lung disease with limited therapeutic options that is characterized by pathological fibroblast activation and aberrant lung remodeling with scar formation. YAP (Yes-associated protein) is a transcriptional coactivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69e7ff705685e150c6c5d62f81c340b
https://europepmc.org/articles/PMC7110981/
https://europepmc.org/articles/PMC7110981/
Autor:
Jan M. Kriegl, Petra Schneider, Michael Bieler, Gisbert Schneider, Michael Reutlinger, Tiago Rodrigues
Publikováno v:
Molecular Informatics. 35:192-198
We present the application of machine learning models to selecting G protein-coupled receptor (GPCR)-focused compound libraries. The library design process was realized by ant colony optimization. A proprietary Boehringer-Ingelheim reference set cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4038c44eb98eb5fb4c95559ec4d2d2b9
https://doi.org/10.1002/minf.201501012
https://doi.org/10.1002/minf.201501012
Autor:
Herbert Koeppen, Michael Bieler
Publikováno v:
Drug Development Research. 73:357-364
Preclinical Research The goal of chemogenomics is the exploration of all possible interactions between compounds from the chemical space and targets from the biological space. This huge interaction matrix is only sparsely filled with experimental dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742e50b01afc865029aca6ddcec53bc1
https://doi.org/10.1002/ddr.21026
https://doi.org/10.1002/ddr.21026
Publikováno v:
SLAS Discovery. 16:683-693
The monocyte chemoattractant protein 1 (MCP-1)-driven activation of CC-type chemokine receptor 2 (CCR2) is one of the early key events to induce monocyte migration toward centers of inflammation. In this work, the authors analyzed MCP-1 internalizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3a50d23cde6996d532fbaa1286340a
https://doi.org/10.1177/1087057111406884
https://doi.org/10.1177/1087057111406884
Publikováno v:
Journal of Chemical Information and Modeling. 51:1897-1905
Computer-based chemogenomics approaches compare macromolecular drug targets based on their amino acid sequences or derived properties, by similarity of their ligands, or according to ligand-target interaction models. Here we present ARTS (Assay Relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244d0635947ec972072232453451b936
https://doi.org/10.1021/ci200105t
https://doi.org/10.1021/ci200105t