Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Michael Beuve"'
Autor:
Anne-Sophie Wozny, Gersende Alphonse, Audrey Cassard, Céline Malésys, Safa Louati, Michael Beuve, Philippe Lalle, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act indepen
Externí odkaz:
https://doaj.org/article/b9246a0bfb4742b4a947afac465121a4
Autor:
Yasmine Ali, Caterina Monini, Etienne Russeil, Jean Michel Létang, Etienne Testa, Lydia Maigne, Michael Beuve
Publikováno v:
Cancers, Vol 14, Iss 7, p 1667 (2022)
For the evaluation of the biological effects, Monte Carlo toolkits were used to provide an RBE-weighted dose using databases of survival fraction coefficients predicted through biophysical models. Biophysics models, such as the mMKM and NanOx models,
Externí odkaz:
https://doaj.org/article/f519fda94d3042ed8458c8cb1daf57cb
Autor:
Anne-Sophie Wozny, Arnaud Gauthier, Gersende Alphonse, Céline Malésys, Virginie Varoclier, Michael Beuve, Delphine Brichart-Vernos, Nicolas Magné, Nicolas Vial, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Cancers, Vol 13, Iss 15, p 3833 (2021)
Hypoxia-Inducible Factor 1α (HIF-1α), which promotes cancer cell survival, is the main regulator of oxygen homeostasis. Hypoxia combined with photon and carbon ion irradiation (C-ions) stabilizes HIF-1α. Silencing HIF-1α under hypoxia leads to su
Externí odkaz:
https://doaj.org/article/8ca5e27fc78d4a77b39ddc35942c2c7d
Autor:
Anne-Sophie Wozny, Guillaume Vares, Gersende Alphonse, Alexandra Lauret, Caterina Monini, Nicolas Magné, Charlotte Cuerq, Akira Fujimori, Jean-Claude Monboisse, Michael Beuve, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Publikováno v:
Cancers, Vol 11, Iss 4, p 468 (2019)
Although conventional radiotherapy promotes the migration/invasion of cancer stem cells (CSCs) under normoxia, carbon ion (C-ion) irradiation actually decreases these processes. Unraveling the mechanisms of this discrepancy, particularly under the hy
Externí odkaz:
https://doaj.org/article/186deb7eace64147ad805372bbea07e2
Autor:
Yasmine Ali, Lucas Auzel, Caterina Monini, Kateryna Kriachok, Jean Michel Létang, Etienne Testa, Lydia Maigne, Michael Beuve
Publikováno v:
Medical Physics
Medical Physics, 2022, 49 (5), pp.3457-3469. ⟨10.1002/mp.15609⟩
Medical Physics, 2022, 49 (5), pp.3457-3469. ⟨10.1002/mp.15609⟩
International audience; PurposeIn hadrontherapy, biophysical models can be used to predict the biological effect received by cancerous tissues and organs at risk. The input data of these models generally consist of information on nano/micro dosimetri
Publikováno v:
Phys.Medica
Phys.Medica, 2021, 88, pp.71-85. ⟨10.1016/j.ejmp.2021.06.006⟩
Phys.Medica, 2021, 88, pp.71-85. ⟨10.1016/j.ejmp.2021.06.006⟩
Purpose To develop a particle transport code to compute w-values and stopping power of swift ions in liquid water and gases of interest for reference dosimetry in hadrontherapy. To analyze the relevance of inelastic and post-collisional processes con
Autor:
A.P. Klapproth, S. Di Maria, W.B. Li, Hans Rabus, Jan Schuemann, B. Heide, B. Rudek, R. Qiu, Carmen Villagrasa, Michael Beuve, Heidi Nettelbeck, F. Poignant
Publikováno v:
Radiat Meas
Radiat. Meas. 147:106637 (2021)
Radiation Measurements, 147, Art.-Nr.: 106637
Radiat. Meas. 147:106637 (2021)
Radiation Measurements, 147, Art.-Nr.: 106637
Organized by the European Radiation Dosimetry Group (EURADOS), a Monte Carlo code intercomparison exercise was conducted where participants simulated the emitted electron spectra and energy deposition around a single gold nanoparticle (GNP) irradiate
Autor:
B. Heide, F. Poignant, C.Y. Li, A.P. Klapproth, W.B. Li, Benedikt Rudek, Jan Schuemann, Hans Rabus, Michael Beuve, S. Di Maria, Carmen Villagrasa, Werner Friedland
Publikováno v:
Physica Medica. 80:383-388
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 12, Iss, Pp 17-21 (2019)
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩
Highlights • The accuracy of biophysical modeling is crucial for particle therapy. • Comparison of LEM(I-IV), MKM and NanOx models with data for 3 cell lines. • χ2 scoring for α(LET) curves. • NanOx yields the highest score more often than
Autor:
S. Di Maria, W.B. Li, Michael Beuve, C.Y. Li, Floriane Poignant, Carmen Villagrasa, A.P. Klapproth, Heidi Nettelbeck, P. A. Hepperle, B. Rudek, Hans Rabus, Jan Schuemann, L. de la Fuente Rosales
Publikováno v:
Physica Medica
Physica Medica, Elsevier, 2021, 84, pp.241-253. ⟨10.1016/j.ejmp.2021.03.005⟩
Phys Med
Physica Medica, Elsevier, 2021, 84, pp.241-253. ⟨10.1016/j.ejmp.2021.03.005⟩
Phys Med
Results of a Monte Carlo code intercomparison exercise for simulations of the dose enhancement from a gold nanoparticle (GNP) irradiated by X-rays have been recently reported. To highlight potential differences between codes, the dose enhancement rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd77a9d10d3ebfb1a5d709ca10cddcf6
https://hal.archives-ouvertes.fr/hal-03257934/file/1-s2.0-S1120179721001216-main.pdf
https://hal.archives-ouvertes.fr/hal-03257934/file/1-s2.0-S1120179721001216-main.pdf