Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michael Bazelot"'
Autor:
Evan Rosenberg, Simon Chamberland, Michael Bazelot, Erica R. Nebet, Xiaohan Wang, Sam McKenzie, Swati Jain, Stuart Greenhill, Max Wilson, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simon D. Sun, Drew Jones, György Buzsáki, Orrin Devinsky, Gavin Woodhall, Helen Scharfman, Benjamin Whalley, Richard Tsien
Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in multiple forms of pediatric epilepsy, but the mechanism(s) of anti-seizure action remain unclear. In one leading model, CBD acts at glutamatergic axon terminals, blocking pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c017031ca8d35fc7181f9820139bc4ce
https://doi.org/10.1101/2022.09.27.509638
https://doi.org/10.1101/2022.09.27.509638
Autor:
Evan C. Rosenberg, Simon Chamberland, Michael Bazelot, Erica R. Nebet, Xiaohan Wang, Sam McKenzie, Swati Jain, Stuart Greenhill, Max Wilson, Nicole Marley, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simón(e) D. Sun, Drew Jones, György Buzsáki, Orrin Devinsky, Gavin Woodhall, Helen E. Scharfman, Benjamin J. Whalley, Richard W. Tsien
Publikováno v:
Neuron. 111:1282-1300.e8
Autor:
Michael Bazelot, Eleni Serafeimidou-Pouliou, Pabitra Hriday Patra, Alister J. McNeish, Claire M. Williams, Benjamin J. Whalley
Publikováno v:
British Journal of Pharmacology
Patra, P H, Serafeimidou-Pouliou, E, Bazelot, M, Whalley, B J, Williams, C M & McNeish, A J 2020, ' Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice ', British Journal of Pharmacology, vol. 177, no. 12, pp. 2779-2792 . https://doi.org/10.1111/bph.15003
Patra, P H, Serafeimidou-Pouliou, E, Bazelot, M, Whalley, B J, Williams, C M & McNeish, A J 2020, ' Cannabidiol improves survival and behavioural co-morbidities of Dravet syndrome in mice ', British Journal of Pharmacology, vol. 177, no. 12, pp. 2779-2792 . https://doi.org/10.1111/bph.15003
Background and Purpose Dravet syndrome is a severe, genetic form of paediatric epilepsy associated with premature mortality and comorbidities such as anxiety, depression, autism, motor dysfunction, and memory deficits. Cannabidiol is an approved anti
Autor:
Michael Bazelot, Nicholas A. Jones, Melissa Barker-Haliski, H. Steve White, Benjamin J. Whalley, Sarah Glyn, Alister J. McNeish, Pabitra Hriday Patra, Claire M. Williams, Haramrit Sandhu
Publikováno v:
Epilepsia
Patra, P H, Barker-Haliski, M, White, H S, Whalley, B J, Glyn, S, Sandhu, H, Jones, N, Bazelot, M, Williams, C M & McNeish, A J 2019, ' Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models ', Epilepsia, vol. 60, no. 2, pp. 303-314 . https://doi.org/10.1111/epi.14629
Patra, P H, Barker-Haliski, M, White, H S, Whalley, B J, Glyn, S, Sandhu, H, Jones, N, Bazelot, M, Williams, C M & McNeish, A J 2019, ' Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models ', Epilepsia, vol. 60, no. 2, pp. 303-314 . https://doi.org/10.1111/epi.14629
Objective Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol (CBD), in a battery of acute seizure models. Additionally, we defined the
Publikováno v:
The Journal of Physiology. 594:2565-2577
Key points The CA3 hippocampal region generates sharp waves (SPW), a population activity associated with neuronal representations. The synaptic mechanisms responsible for the generation of these events still require clarification. Using slices mainta
Autor:
Benjamin J. Whalley, Michael Bazelot, Colin Stott, Royston A. Gray, Kathryn Nichol, Nicholas A. Jones
Publikováno v:
Epilepsy & Behavior. 101:106734
Autor:
Ines Serra, Claire M. Williams, Michael Bazelot, Mark L. Dallas, Chloë Scheldeman, Peter de Witte, Benjamin J. Whalley
Publikováno v:
Behavioural brain research. 363
Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in the TSC1 or TSC2 genes and is characterized by widespread tumour growth, intractable epilepsy, cognitive deficits and autistic behaviour. CBD has been reported to decrease seiz
Autor:
Hans-Christian Pape, Lena Goedecke, Peter Blaesse, Marco Capogna, Kay Jüngling, Michael Bazelot
Publikováno v:
The Journal of Neuroscience. 35:7317-7325
The amygdala is a key region for the processing of information underlying fear, anxiety, and fear extinction. Within the local neuronal networks of the amygdala, a population of inhibitory, intercalated neurons (ITCs) modulates the flow of informatio
Autor:
Richard B. Miles, Desdemona Fricker, Elodie Bruel-Jungerman, Fiona Francis, Jean Simonnet, Michael Bazelot, Céline Dinocourt
Publikováno v:
European Journal of Neuroscience. 35:244-256
We report data on the neuronal form, synaptic connectivity, neuronal excitability and epileptiform population activities generated by the hippocampus of animals with an inactivated doublecortin gene. The protein product of this gene affects neuronal
Autor:
Michael Bazelot, Tong Chen, Alistair V.W. Nunn, Benjamin J. Whalley, Clementino Ibeas Bih, Mark L. Dallas
Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use. Until recently, alleged clinical effects from anecdotal reports and the use of licensed cannabinoid medicines are most likely mediated by tetrahydrocannabinol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a181030a068895543f18a9d39490503
https://europepmc.org/articles/PMC4604182/
https://europepmc.org/articles/PMC4604182/