Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael Basic"'
Autor:
Qingyan Wu, Mirco Glitscher, Susanne Tonnemacher, Anja Schollmeier, Jan Raupach, Tobias Zahn, Regina Eberle, Jacomine Krijnse-Locker, Michael Basic, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 1, Pp 237-259 (2023)
Background & Aims: Hepatitis B virus (HBV) was identified as an enveloped DNA virus with a diameter of 42 nm. Multivesicular bodies play a central role in HBV egress and exosome biogenesis. In light of this, it was studied whether intact virions wrap
Externí odkaz:
https://doaj.org/article/cdea57c472a2429dbc1ff347218eb19c
Publikováno v:
Viruses, Vol 15, Iss 8, p 1687 (2023)
Hepatitis D virus (HDV) is a defective RNA virus with a negative-strand RNA genome encompassing less than 1700 nucleotides. The HDV genome encodes only for one protein, the hepatitis delta antigen (HDAg), which exists in two forms acting as nucleopro
Externí odkaz:
https://doaj.org/article/c22cf97a554d41bfa6bb1233abd48a1a
Autor:
Kai-Henrik Peiffer, Catrina Spengler, Michael Basic, Bingfu Jiang, Lisa Kuhnhenn, Wiebke Obermann, Tobias Zahn, Mirco Glitscher, Alessandro Loglio, Floriana Facchetti, Gert Carra, Alica Kubesch, Johannes Vermehren, Viola Knop, Christiana Graf, Julia Dietz, Fabian Finkelmeier, Eva Herrmann, Jonel Trebicka, Arnold Grünweller, Stefan Zeuzem, Christoph Sarrazin, Pietro Lampertico, Eberhard Hildt
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Many mutation analyses of the HBV genome have been performed in the search for new prognostic markers. However, the Kozak sequence preceding precore was covered only infrequently in these analyses. In this study, the HBV core promoter/precore region
Externí odkaz:
https://doaj.org/article/ad965b77b3ad42bfb034cd0860b5610d
Autor:
Bingfu Jiang, Xingjian Wen, Qingyan Wu, Daniela Bender, Gert Carra, Michael Basic, Alica Kubesch, Kai-Henrik Peiffer, Klaus Boller, Eberhard Hildt
Publikováno v:
Cells, Vol 9, Iss 8, p 1898 (2020)
The N-terminus of the hepatitis B virus (HBV) large surface protein (LHB) differs with respect to genotypes. Compared to the amino terminus of genotype (Gt)D, in GtA, GtB and GtC, an additional identical 11 amino acids (aa) are found, while GtE and G
Externí odkaz:
https://doaj.org/article/e0b22757b5514a5e8cebb69b26647c4b
Autor:
Catarina Sabino, Michael Basic, Daniela Bender, Fabian Elgner, Kiyoshi Himmelsbach, Eberhard Hildt
Publikováno v:
Viruses, Vol 11, Iss 6, p 524 (2019)
Zika virus (ZIKV) is a highly transmissive virus that belongs to the Flaviviridae family, which comprises several other pathogens that threaten human health. This re-emerging virus gained attention during the outbreak in Brazil in 2016, where a consi
Externí odkaz:
https://doaj.org/article/28574d2f603b4ac6a484e1c30c2e19ae
Autor:
Fabian Elgner, Catarina Sabino, Michael Basic, Daniela Ploen, Arnold Grünweller, Eberhard Hildt
Publikováno v:
Viruses, Vol 10, Iss 4, p 149 (2018)
The Zika virus (ZIKV) outbreak in 2016 in South America with specific pathogenic outcomes highlighted the need for new antiviral substances with broad-spectrum activities to react quickly to unexpected outbreaks of emerging viral pathogens. Very rece
Externí odkaz:
https://doaj.org/article/74a12f0bf4a24fcdacf6c41e7ecf4994
Autor:
Eberhard Hildt, Annemarie Berger, Esra Görgülü, Marcus M. Mücke, K.-H. Peiffer, Julia Dietz, Christoph Sarrazin, Fabian Finkelmeier, Lisa Kuhnhenn, Michael Basic, Alica Kubesch, Victoria T. Mücke, Stefan Zeuzem, Mate Knabe
Publikováno v:
Liver international, 41(6):1278-1289
Background & Aims HBV genotype G (HBV/G) is mainly found in co-infections with other HBV genotypes and was identified as an independent risk factor for liver fibrosis. This study aimed to analyse the prevalence of HBV/G co-infections in healthy Europ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4f0b2bb0d2fe577bf51ab94da6cc87
https://doi.org/10.1111/liv.14884
https://doi.org/10.1111/liv.14884
Autor:
Michael Basic, Qingyan Wu, Anja Schollmeier, Christoph Sarrazin, Stefan Zeuzem, Eberhard Hildt, Kai-Henrik Peiffer
Publikováno v:
Zeitschrift für Gastroenterologie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57da237e80921faeb3b67731fbfa3f4
https://doi.org/10.1055/s-0041-1740795
https://doi.org/10.1055/s-0041-1740795
Autor:
Fabian Barthels, Melissa Immerheiser, Michael Basic, Nathalie Jung, Jochen Bodem, Andrea Gellert, Christian Kersten, Tanja Schirmeister, Werner Kiefer, Ute A. Hellmich, Stefan Hammerschmidt, Eberhard Hildt, Fabian Elgner, Maike Windbergs, Benedikt Millies, Ulrike Göppel, Franziska von Hammerstein
Publikováno v:
Journal of Medicinal Chemistry. 62:11359-11382
The NS2B/NS3 serine proteases of the Zika and Dengue flaviviruses are attractive targets for the development of antiviral drugs. We report the synthesis and evaluation of a new, proline-based compound class that displays allosteric inhibition of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff917177811dc90b36f1466e2bf606c
https://doi.org/10.1021/acs.jmedchem.9b01697
https://doi.org/10.1021/acs.jmedchem.9b01697
Autor:
Michael Basic, Qingyan Wu, Anja Schollmeier, Christoph Sarrazin, Stefan Zeuzem, Eberhard Hildt, Kai-Henrik Peiffer
Publikováno v:
Journal of Hepatology. 77:S262
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9c399e2dc5e5705ae23aeba1f0c41bd
https://doi.org/10.1016/s0168-8278(22)00893-5
https://doi.org/10.1016/s0168-8278(22)00893-5