Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Michael B. Fessler"'
Autor:
Teminioluwa Ajayi, Prashant Rai, Min Shi, Kristin A. Gabor, Peer W. F. Karmaus, Julie M. Meacham, Kevin Katen, Jennifer H. Madenspacher, Shepherd H. Schurman, Michael B. Fessler
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Immunity-related GTPase family M (IRGM), located on human chromosome 5q33.1, encodes a protein that promotes autophagy and suppresses the innate immune response. The minor allele of rs13361189 (−4299T>C), a single nucleotide polymorphism i
Externí odkaz:
https://doaj.org/article/e628dea807ef402180a15f40be103787
Autor:
Florencia Pascual, Mert Icyuz, Peer Karmaus, Ashley Brooks, Elizabeth Van Gorder, Michael B. Fessler, Natalie D. Shaw
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Cranial neural crest cells (cNCC) are a multipotent embryonic cell population that give rise to a diverse set of cell types. These cells are particularly vulnerable to external metabolic stressors, as exemplified by the association between m
Externí odkaz:
https://doaj.org/article/e11e83645f34439cb6ecbcad90b2e1b1
Autor:
Prashant Rai, Martin Sharpe, Charan K. Ganta, Paul J. Baker, Katrin D. Mayer-Barber, Brian E. Fee, Gregory A. Taylor, Michael B. Fessler
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
Externí odkaz:
https://doaj.org/article/6ca47ef1b2184a5eb91872baf4a58d7d
Autor:
Wenling Li, Hideki Nakano, Wei Fan, Yuanyuan Li, Payel Sil, Keiko Nakano, Fei Zhao, Peer W. Karmaus, Sara A. Grimm, Min Shi, Xin Xu, Ryushin Mizuta, Daisuke Kitamura, Yisong Wan, Michael B. Fessler, Donald N. Cook, Igor Shats, Xiaoling Li, Leping Li
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to development of autoimmune diseases in both humans and mice. However, despite the wel
Externí odkaz:
https://doaj.org/article/eba649c4683647208269358c9f30e162
Autor:
Eunice Y. Lee, Wonson Choi, Adam B. Burkholder, Lalith Perera, Jasmine A. Mack, Frederick W. Miller, Michael B. Fessler, Donald N. Cook, Peer W. F. Karmaus, Hideki Nakano, Stavros Garantziotis, Jennifer H. Madenspacher, John S. House, Farida S. Akhtari, Charles S. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct genetic architecture associated w
Externí odkaz:
https://doaj.org/article/b4c25f7994204ed68ceec9b548045815
Autor:
Paivi M. Salo, Angelico Mendy, Jesse Wilkerson, Samantha A. Molsberry, Lydia Feinstein, Stephanie J. London, Michael B. Fessler, Peter S. Thorne, Darryl C. Zeldin
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Oxidative stress plays a key role in the pathogenesis of respiratory diseases; however, studies on antioxidant vitamins and respiratory outcomes have been conflicting. We evaluated whether lower serum levels of vitamins A, C, D, a
Externí odkaz:
https://doaj.org/article/20f63ceab6f74a26a38ab14e87f2f4f7
Autor:
Jennifer H. Madenspacher, Eric D. Morrell, Jeffrey G. McDonald, Bonne M. Thompson, Yue Li, Konstantin G. Birukov, Anna A. Birukova, Renee D. Stapleton, Aidin Alejo, Peer W. Karmaus, Julie M. Meacham, Prashant Rai, Carmen Mikacenic, Mark M. Wurfel, Michael B. Fessler
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined. Recently, we reported that Ch25h is induced in monocyte-derived macrop
Externí odkaz:
https://doaj.org/article/1109a8bf1a3b4286b2173352ad418326
Autor:
Montserrat Ayala-Ramirez, Nathaniel MacNell, Lucy E. McNamee, John A. McGrath, Farida S. Akhtari, Matthew D. Curry, Askia K. Dunnon, Michael B. Fessler, Stavros Garantziotis, Christine G. Parks, David C. Fargo, Charles P. Schmitt, Alison A. Motsinger-Reif, Janet E. Hall, Frederick W. Miller, Shepherd H. Schurman
Publikováno v:
Environment International, Vol 171, Iss , Pp 107687- (2023)
Background: Concentrated animal feeding operations (CAFOs) are a source of environmental pollution and have been associated with a variety of health outcomes. Immune-mediated diseases (IMD) are characterized by dysregulation of the normal immune resp
Externí odkaz:
https://doaj.org/article/6fd750625d1e400ea420cb3e832fe69d
Autor:
Gentaro Izumi, Hideki Nakano, Keiko Nakano, Gregory S. Whitehead, Sara A. Grimm, Michael B. Fessler, Peer W. Karmaus, Donald N. Cook
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dendritic cells in the lung may be specialised to mediate specific types of immune function. Here the authors show that subpopulations of mouse CD11b+ lung DC at different stages of maturation and phenotype can promote Th17 or Th2 CD4+ T cell differe
Externí odkaz:
https://doaj.org/article/2d7e7a34ad9741c7b9cd97853b90ab3b
Autor:
Qingxia Zhao, Zhan Wang, Allison K. Meyers, Jennifer Madenspacher, Manal Zabalawi, Qianyi Zhang, Elena Boudyguina, Fang-Chi Hsu, Charles E. McCall, Cristina M. Furdui, John S. Parks, Michael B. Fessler, Xuewei Zhu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Macrophages play a central role in the pathogenesis of atherosclerosis. Our previous study demonstrated that solute carrier family 37 member 2 (SLC37A2), an endoplasmic reticulum-anchored phosphate-linked glucose-6-phosphate transporter, negatively r
Externí odkaz:
https://doaj.org/article/faf5fd19e0c94aa199d2c274dfbde07e