Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael B. Drennan"'
Autor:
Srinath Govindarajan, Djoere Gaublomme, Renée Van der Cruyssen, Eveline Verheugen, Sofie Van Gassen, Yvan Saeys, Simon Tavernier, Takao Iwawaki, Yehudi Bloch, Savvas. N. Savvides, Bart N. Lambrecht, Sophie Janssens, Dirk Elewaut, Michael B. Drennan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear. Here the authors show that an endoplasmic reticulum stress sensor, inositol-requirin
Externí odkaz:
https://doaj.org/article/b6d32051b63e4b37881f01ffdff4d01b
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids
Autor:
Michael B. Drennan, Koen Venken, Djoere Gaublomme, Srinath Govindarajan, Margaux Maelegheer, Fien Gysens, Eveline Verheugen, Eva Cloots, Dirk Elewaut, Tan-Yun Cheng, Bruno G. De Geest, D. Branch Moody, Sophie Janssens
Publikováno v:
EMBO Reports
EMBO REPORTS
EMBO REPORTS
CD1d‐restricted invariant natural killer T (iNKT) cells constitute a common glycolipid‐reactive innate‐like T‐cell subset with a broad impact on innate and adaptive immunity. While several microbial glycolipids are known to activate iNKT cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5f790b80e08cb81ec173ffff794d83
http://europepmc.org/articles/PMC7271650
http://europepmc.org/articles/PMC7271650
Autor:
Dirk Elewaut, Srinath Govindarajan, Georges Leclercq, Michael B. Drennan, Geert van Loo, Rudi Beyaert, Eveline Verheugen, Jens Staal, Conor McGuire, Jonathan M. Coquet, Bart N. Lambrecht, Tom Taghon
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 213(10), 1973-1981. Rockefeller University Press
JOURNAL OF EXPERIMENTAL MEDICINE
Journal of Experimental Medicine, 213(10), 1973-1981. Rockefeller University Press
JOURNAL OF EXPERIMENTAL MEDICINE
Drennan et al. use a new mouse to show that A20-deficient NKT cells are hyperresponsive to TCR-dependent stimuli and have severely impaired NKT cell development.
Natural killer T (NKT) cells are innate lymphocytes that differentiate into NKT1, N
Natural killer T (NKT) cells are innate lymphocytes that differentiate into NKT1, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eccec7f2eb7b3093d7e5d5451f5ef4
https://doi.org/10.1084/jem.20151065
https://doi.org/10.1084/jem.20151065
Publikováno v:
Nature Reviews Rheumatology. 12:398-411
The human gut harbours a tremendously diverse and abundant microbial community that correlates with, and even modulates, many health-related processes. The mucosal interfaces are particularly active sites of microorganism-host interplay. Growing insi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff5fda46882898d8a4e4f71a341954b
https://doi.org/10.1038/nrrheum.2016.85
https://doi.org/10.1038/nrrheum.2016.85
Autor:
Michael B. Drennan, S. Van Calenbergh, Lennart Zabeau, Mérédis Favreau, Sylvia Faict, E. De Bruyne, Srinath Govindarajan, Karin Vanderkerken, Eline Menu, Dirk Elewaut, Ken Maes, Koen Venken, Jan Tavernier, Djoere Gaublomme, Xavier Leleu
Publikováno v:
Leukemia. 31(12)
A hallmark of bone marrow changes with aging is the increase in adipocyte composition, but how this impacts development of multiple myeloma (MM) is unknown. Here, we report the role of the adipokine leptin as master regulator of anti-myeloma tumor im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceda29686369bf3a1fbeeca37b4a044c
https://pubmed.ncbi.nlm.nih.gov/28490813
https://pubmed.ncbi.nlm.nih.gov/28490813
Autor:
Karlijn Debusschere, Michael B. Drennan, Dennis McGonagle, Fien Windels, Peggy Jacques, Leen Catrysse, Katelijne De Wilde, Arne Martens, Geert van Loo, Rudi Beyaert, Rik Lories, Srinath Govindarajan, Eveline Verheugen, Stijn Lambrecht, Julie Coudenys, Dirk Elewaut
Publikováno v:
Annals of the rheumatic diseases. 76(3)
ObjectivesA20 is an important endogenous regulator of inflammation. Single nucleotide polymorphisms in A20 have been associated with various immune-mediated inflammatory diseases, and cell-specific deletion of A20 results in diverse inflammatory phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec52f83f039e8a6b836464bb300423e2
https://pubmed.ncbi.nlm.nih.gov/27551052
https://pubmed.ncbi.nlm.nih.gov/27551052
Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis
Autor:
Serge Van Calenbergh, Michael B. Drennan, Dirk Elewaut, Yali Li, Richard W. Franck, Dirk M. Zajonc, Katrien Van Beneden, Nora Pauwels, Koen Venken, Jing Wang, Esther Dawen Yu, Enrico Girardi, Tine Decruy, Matthias Trappeniers, Luc Leybaert, Sandrine Aspeslagh
Publikováno v:
The EMBO Journal. 30:2294-2305
Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel class of aromatic α-galactosylcer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5857da8a5a3288534f6d9114c8a0a0fb
https://doi.org/10.1038/emboj.2011.145
https://doi.org/10.1038/emboj.2011.145
Autor:
Martine De Vos, Dieter Deforce, Koen Venken, Maria Apostolaki, Peggy Jacques, Bart N. Lambrecht, Gust Verbruggen, Sylvie Seeuws, Hamida Hammad, George Kollias, Michael B. Drennan, Katrien Van Beneden, Dirk Elewaut
Publikováno v:
Arthritis & Rheumatism. 62:988-999
Objective. To investigate the role of invariant natural killer T (iNKT) cells in TNF Delta ARE/+ mice, an animal model of spondylarthritis (SpA) with both gut and joint inflammation. Methods. The frequency and activation of iNKT cells were analyzed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3d4641ba13003fa90e6c5eaeef3e2d
https://doi.org/10.1002/art.27324
https://doi.org/10.1002/art.27324
Publikováno v:
Nature Reviews Rheumatology. 6:90-98
Invariant natural killer T (iNKT) cells are an innate T-cell lineage known to recognize a range of endogenously derived and exogenously derived glycolipid antigens. Advances in our understanding of this T-cell subset have enabled researchers to inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104d786e66f12da6fb5b8dd004929f42
https://doi.org/10.1038/nrrheum.2009.261
https://doi.org/10.1038/nrrheum.2009.261
Autor:
Katrien Van Beneden, Dieter Deforce, Emma C. Reilly, Reina E. Mebius, Michael B. Drennan, Thomas E. Lane, Sylvie Seeuws, Ann Sophie Franki, Serge A. van de Pavert, Dirk Elewaut, Pieter Dewint, Gust Verbruggen
Publikováno v:
Drennan, M B, Franki, A S, Dewint, P, Van Beneden, K, Seeuws, S, van de Pavert, S A, Reilly, E C, Verbruggen, G, Lane, T E, Mebius, R E, Deforce, D & Elewaut, D 2009, ' Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus ', Journal of Immunology, vol. 183, no. 4, pp. 2213-2216 . https://doi.org/10.4049/jimmunol.0901213
Journal of Immunology, 183(4), 2213-2216. American Association of Immunologists
Journal of Immunology, 183(4), 2213-2216. American Association of Immunologists
The current model used to define T cell export from the thymus suggests that emigrating lymphocytes seed the peripheral organs as functionally mature cells. This model holds true for the majority of T cells exported from the thymus with the exception
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0211ddb59d9ef8d11454945e194d1f7d
https://doi.org/10.4049/jimmunol.0901213
https://doi.org/10.4049/jimmunol.0901213