Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael B. Doughty"'
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 22:283-297
Nucleotides 2-(4-azidophenacyl)thio-1,N6-etheno-2'-deoxyadenosine 5'-triphosphate 1 and its tetrafluoro analog 2 inhibit HIV-1 reverse transcriptase (RT) competitively relative to template. These template-competitive RT inhibitors (TCRTIs) were analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679a2973865ead18d2f73b5ef2cdefaa
https://doi.org/10.1081/ncn-120021428
https://doi.org/10.1081/ncn-120021428
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:4131-4141
Analogues of a novel class of template-competitive reverse transcriptase inhibitors (Li, K.; Lin, W.; Chong, K. H.; Moore, B. M.; Doughty, M. B. Bioorg. Med. Chem. 2002 , 10 , 507) were analyzed as photoprobes of HIV-1 reverse transcriptase (RT) hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5875da9f9ede0b869a1ab682fe149b
https://doi.org/10.1016/s0968-0896(02)00259-6
https://doi.org/10.1016/s0968-0896(02)00259-6
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:507-515
We report the design, synthesis and activity studies on a novel class of template-competitive reverse transcriptase inhibitors (TCRTIs). The TCRTIs are 1,N(6)-etheno analogues of a series of dATP-based template-competitive DNA polymerase inhibitors s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d587a02dfb7047e0c5eb977241f9f813
https://doi.org/10.1016/s0968-0896(01)00297-8
https://doi.org/10.1016/s0968-0896(01)00297-8
Publikováno v:
Biochemistry. 35:11634-11641
DNA polymerase photoprobes 2-[(4-azidophenacyl)thio]-2'-deoxyadenosine 5'-triphosphate (1), 2-[(4-azidophenylsulfenyl)thio]-2'-deoxyadenosine 5'-triphosphate (2), and 2-[(4-azido-2-nitrophenyl)-thio]-2'-deoxyadenosine 5'-triphosphate (3) were designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e341697f0522ca2ce07b8f23e8ea1e9
https://doi.org/10.1021/bi952514u
https://doi.org/10.1021/bi952514u
Publikováno v:
Journal of the American Chemical Society. 117:8502-8510
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba5a6377220863e39ac9ee98664ff05a
https://doi.org/10.1021/ja00138a002
https://doi.org/10.1021/ja00138a002
Publikováno v:
Nucleosides and Nucleotides. 14:65-76
We prepared 2-azido-1, N6-etheno-2′-deoxyadenosine 5′-monophosphate (7b) by activation of the 2-thio analog 4b by two methods. In the preferred method, 4b was treated with 2,4-dinitrofluorobenzene in 50% aqueous acetonitrile, and the resultant th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a344e3456a1ee0ab925ca2153ce03743
https://doi.org/10.1080/15257779508014653
https://doi.org/10.1080/15257779508014653
Autor:
Michael J. McLeish, Michael B. Doughty, Katherine J. Nielsen, Lidia V. Najbar, John D. Wade, David J. Craik, Feng Lin
Publikováno v:
Biochemistry. 33:11174-11183
The conformation, in solution, of a peptide corresponding to residues 59-81 from T4 lysozyme [LYS(59-81)] has been determined by H-1 NMR and CD spectroscopy. This peptide spans the region corresponding to helix C in the crystal structure of T4 lysozy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369e7afe0c41687d8d8d57a70d22ffd4
https://doi.org/10.1021/bi00203a013
https://doi.org/10.1021/bi00203a013
Publikováno v:
Journal of Medicinal Chemistry. 37:2242-2248
We synthesized a new series of benextramine analogs as neuropeptide Y (NPY) functional group mimetics and tested them for N-[propionyl-3H]NPY ([3]NPY) displacement activity in rat brain membrane homogenates and for NPY receptor antagonist activity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e021b1b1757824525b70d5cad07bfbe
https://doi.org/10.1021/jm00040a018
https://doi.org/10.1021/jm00040a018
Publikováno v:
Neuropeptides. 25:289-298
Effects of calcium-free buffer, nifedipine, or prior cumulative neuropeptide Y (NPY) receptor agonist concentration exposure on vasoconstrictive responsiveness to the agonists were assessed in norepinephrine (NE)-conditioned isolated rat femoral arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c68d8ce430057a904abf133ecc0327
https://doi.org/10.1016/0143-4179(93)90046-d
https://doi.org/10.1016/0143-4179(93)90046-d
Publikováno v:
ChemInform. 33
We report the design, synthesis and activity studies on a novel class of template-competitive reverse transcriptase inhibitors (TCRTIs). The TCRTIs are 1,N(6)-etheno analogues of a series of dATP-based template-competitive DNA polymerase inhibitors s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab4b0749d07f0ea8448934506d2e53ea
https://doi.org/10.1002/chin.200220172
https://doi.org/10.1002/chin.200220172