Zobrazeno 1 - 10
of 616
pro vyhledávání: '"Michael B. A. Oldstone"'
Autor:
Michael B. A. Oldstone, Brian C. Ware, Amanda Davidson, Mark C. Prescott, Robert J. Beynon, Jane L. Hurst
Publikováno v:
Viruses, Vol 13, Iss 6, p 1180 (2021)
Mature male mice produce a particularly high concentration of major urinary proteins (MUPs) in their scent marks that provide identity and status information to conspecifics. Darcin (MUP20) is inherently attractive to females and, by inducing rapid a
Externí odkaz:
https://doaj.org/article/20417bf018774bca9b7b2806b7221c22
Publikováno v:
Viruses, Vol 13, Iss 7, p 1189 (2021)
During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to this loss of function, CD8 T cells with the highest affinity for viral antigen can be physic
Externí odkaz:
https://doaj.org/article/c0f54536b8c94e5a9911dad543a997ee
Autor:
Stephanie M LaVergne, Saori Sakabe, Mambu Momoh, Lansana Kanneh, Nell Bond, Robert F Garry, Donald S Grant, Juan Carlos de la Torre, Michael B A Oldstone, John S Schieffelin, Brian M Sullivan
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010882 (2022)
IntroductionLassa virus is a priority pathogen for vaccine research and development, however the duration of cellular immunity and protection in Lassa fever (LF) survivors remains unclear.MethodsWe investigated Lassa virus specific CD8+ T cell respon
Externí odkaz:
https://doaj.org/article/05c06e0c5ecb4de5ae3d196d12bee36a
Autor:
Michael B. A. Oldstone M.D
The story of viruses and humanity is a story of fear and ignorance, of grief and heartbreak, and of great bravery and sacrifice. Michael Oldstone tells all these stories as he illuminates the history of the devastating diseases that have tormented hu
Autor:
Jaroslav Zak, Isaraphorn Pratumchai, Brett S. Marro, Kristi L. Marquardt, Reza Beheshti Zavareh, Luke L. Lairson, Michael B. A. Oldstone, Judith A. Varner, Veronika Bachanova, John R. Teijaro
Unleashing anti-tumor T cell activity by checkpoint inhibition is effective in many cancer patients but clinical response rates remain limited. Myeloid derived suppressor cells erode antitumor lymphocyte numbers and function, and correlate with resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd14018787c7a6913d7e2905fa89cd8
https://doi.org/10.1101/2022.06.24.497435
https://doi.org/10.1101/2022.06.24.497435
Autor:
Luke L. Lairson, Reza Beheshti Zavareh, Michael B. A. Oldstone, Jaroslav Zak, John R. Teijaro, Brett S. Marro
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3293-3302.e3 (2019)
Summary: Inhibitory receptors (IRs) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression o
Publikováno v:
PLoS Pathogens, Vol 11, Iss 1, p e1004588 (2015)
Many persistent viral infections are characterized by a hypofunctional T cell response and the upregulation of negative immune regulators. These events occur days after the initiation of infection. However, the very early host-virus interactions that
Externí odkaz:
https://doaj.org/article/08b1164fefcf4e30919e0f7d366a70b5
Publikováno v:
Viruses, Vol 13, Iss 1189, p 1189 (2021)
Viruses
Volume 13
Issue 7
Viruses
Volume 13
Issue 7
During chronic viral infections, CD8 T cells rapidly lose antiviral and immune-stimulatory functions in a sustained program termed exhaustion. In addition to this loss of function, CD8 T cells with the highest affinity for viral antigen can be physic
Autor:
Michael B. A. Oldstone, Brian M. Sullivan, Brett S. Marro, Kevin P. Campbell, Toru Egashira, Stephanie LaVergne, John H. Elder, Brian C. Ware
Publikováno v:
Proceedings of the National Academy of Sciences. 116:18001-18008
Lymphocytic choriomeningitis virus (LCMV) WE variant 2.2 (v2.2) generated a high level of the major mouse urinary protein: MUP. Mice infected with LCMV WE v54, which differed from v2.2 by a single amino acid in the viral glycoprotein, failed to gener
Autor:
Hugh Rosen, Michael B. A. Oldstone
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine
The severity of coronavirus disease 2019 (COVID‐19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine‐1‐phosphate (S1P) along with severity markers, in COVID‐19 patien