Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Michael B Yaffe"'
Autor:
Fred C. Lam, Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael B Yaffe, Scott R Floyd, Paula T Hammond
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The blood-brain barrier often limits effective delivery of treatments for glioblastoma . In this study, the authors develop transferrin-functionalized nanoparticles able to traverse the intact blood-brain barrier and deliver combination temozolomide
Externí odkaz:
https://doaj.org/article/7b4a074c2e9340cbb338535cafd8e632
Autor:
Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, Brian A Joughin, Chad J Miller, Nasir Haider, Craig D Simpson, Rune Linding, Vuk Stambolic, Benjamin E Turk, Michael B Yaffe
Publikováno v:
eLife, Vol 8 (2019)
Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We systematically determined the phosphorylation-site motifs for the entire Nek kinase family, except for Nek11. While all Nek kinases st
Externí odkaz:
https://doaj.org/article/2383e1c7cf71416b992c19851aaee933
Autor:
Chad J Miller, Hua Jane Lou, Craig Simpson, Bert van de Kooij, Byung Hak Ha, Oriana S Fisher, Natasha L Pirman, Titus J Boggon, Jesse Rinehart, Michael B Yaffe, Rune Linding, Benjamin E Turk
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e2006540 (2019)
Specificity within protein kinase signaling cascades is determined by direct and indirect interactions between kinases and their substrates. While the impact of localization and recruitment on kinase-substrate targeting can be readily assessed, evalu
Externí odkaz:
https://doaj.org/article/4ebc7355466a4a8d843960e4922a2832
Autor:
Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Wouter W. Wiegant, Pau Creixell, Merula Stout, Brian A. Joughin, Julia Vornberger, Matthias Altmeyer, Marcel A. T. M. van Vugt, Michael B. Yaffe, Haico van Attikum
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract During the repair of interstrand crosslinks (ICLs) a DNA double-strand break (DSB) is generated. The Fanconi anemia (FA) core complex, which is recruited to ICLs, promotes high-fidelity repair of this DSB by homologous recombination (HR). Ho
Externí odkaz:
https://doaj.org/article/8089b7910a9a4e0b88480d0ad31ef39a
Autor:
Ting Dong, Guangan Hu, Zhongqi Fan, Huirui Wang, Yinghui Gao, Sisi Wang, Hao Xu, Michael B. Yaffe, Matthew G. Vander Heiden, Guoyue Lv, Jianzhu Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Kupffer cells are liver resident macrophages and play critical role in fatty liver disease, yet the underlying mechanisms remain unclear. Here, we show that activation of G-protein coupled receptor 3 (GPR3) in Kupffer cells stimulates glycol
Externí odkaz:
https://doaj.org/article/83d25661a3af40cb9b261bb33f972632
Autor:
Wendy Niedelman, Daniel A Gold, Emily E Rosowski, Joris K Sprokholt, Daniel Lim, Ailan Farid Arenas, Mariane B Melo, Eric Spooner, Michael B Yaffe, Jeroen P J Saeij
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002784 (2012)
The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the immune response allowing it to establish a chronic infection. Crosses between the types I, II and III strains, which are prevalent
Externí odkaz:
https://doaj.org/article/8d15070ac0ea4b4a99ca429118b77d59
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 7, p e1002119 (2011)
Advances in proteomic technologies continue to substantially accelerate capability for generating experimental data on protein levels, states, and activities in biological samples. For example, studies on receptor tyrosine kinase signaling networks c
Externí odkaz:
https://doaj.org/article/af8d764284f24510982dfb8530f1e089
Autor:
Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000287 (2010)
DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage ch
Externí odkaz:
https://doaj.org/article/4f174f4259f044698e196166a19c278f
Autor:
Mark E Burkard, John Maciejowski, Verónica Rodriguez-Bravo, Michael Repka, Drew M Lowery, Karl R Clauser, Chao Zhang, Kevan M Shokat, Steven A Carr, Michael B Yaffe, Prasad V Jallepalli
Publikováno v:
PLoS Biology, Vol 7, Iss 5, p e1000111 (2009)
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues pr
Externí odkaz:
https://doaj.org/article/efcc32a4efcb4dc7bae4cafa4776e364
Autor:
Renske van Leuken, Linda Clijsters, Wouter van Zon, Dan Lim, XueBiao Yao, Rob M F Wolthuis, Michael B Yaffe, René H Medema, Marcel A T M van Vugt
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5282 (2009)
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also required for
Externí odkaz:
https://doaj.org/article/5bdd7095f17b43e5addb2cbe505d25b1