Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Michael B Stadler"'
Autor:
Federica Zilli, Pedro Marques Ramos, Priska Auf der Maur, Charly Jehanno, Atul Sethi, Marie‐May Coissieux, Tobias Eichlisberger, Loïc Sauteur, Adelin Rouchon, Laura Bonapace, Joana Pinto Couto, Roland Rad, Michael Rugaard Jensen, Andrea Banfi, Michael B Stadler, Mohamed Bentires‐Alj
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Metastasis is the main cause of deaths related to solid cancers. Active transcriptional programmes are known to regulate the metastatic cascade but the molecular determinants of metastatic colonization remain elusive. Using an inducible pigg
Externí odkaz:
https://doaj.org/article/42ad8c50455f42c9bfe8d2e92e8ddc15
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008585 (2021)
Experimental single-cell approaches are becoming widely used for many purposes, including investigation of the dynamic behaviour of developing biological systems. Consequently, a large number of computational methods for extracting dynamic informatio
Externí odkaz:
https://doaj.org/article/c4e81451c939466c90f9213f7e7e427e
Autor:
Christina Fassnacht, Cristina Tocchini, Pooja Kumari, Dimos Gaidatzis, Michael B Stadler, Rafal Ciosk
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007252 (2018)
Endogenous RNAi (endoRNAi) is a conserved mechanism for fine-tuning gene expression. In the nematode Caenorhabditis elegans, several endoRNAi pathways are required for the successful development of reproductive cells. The CSR-1 endoRNAi pathway promo
Externí odkaz:
https://doaj.org/article/1f6d33589c4644f5957d2543a5183fbd
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006313 (2016)
XRN2 is a conserved 5'→3' exoribonuclease that complexes with proteins that contain XRN2-binding domains (XTBDs). In Caenorhabditis elegans (C. elegans), the XTBD-protein PAXT-1 stabilizes XRN2 to retain its activity. XRN2 activity is also promoted
Externí odkaz:
https://doaj.org/article/04bf6153e36f4924ad7eeb2c808ed85e
Autor:
Hélène Royo, Hervé Seitz, Elias ElInati, Antoine H F M Peters, Michael B Stadler, James M A Turner
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005461 (2015)
During the pachytene stage of meiosis in male mammals, the X and Y chromosomes are transcriptionally silenced by Meiotic Sex Chromosome Inactivation (MSCI). MSCI is conserved in therian mammals and is essential for normal male fertility. Transcriptom
Externí odkaz:
https://doaj.org/article/8cc5d14bf296465db956a49ab9f12121
Autor:
Debora Schmitz-Rohmer, Simone Probst, Zhong-Zhou Yang, Frédéric Laurent, Michael B Stadler, Aimée Zuniga, Rolf Zeller, Debby Hynx, Brian A Hemmings, Alexander Hergovich
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136566 (2015)
Studies of mammalian tissue culture cells indicate that the conserved and distinct NDR isoforms, NDR1 and NDR2, play essential cell biological roles. However, mice lacking either Ndr1 or Ndr2 alone develop normally. Here, we studied the physiological
Externí odkaz:
https://doaj.org/article/654538069ff24c9aa7e82c33a337670c
Autor:
Cristina Tocchini, Jeremy J Keusch, Sarah B Miller, Susanne Finger, Heinz Gut, Michael B Stadler, Rafal Ciosk
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004533 (2014)
The mechanisms controlling cell fate determination and reprogramming are fundamental for development. A profound reprogramming, allowing the production of pluripotent cells in early embryos, takes place during the oocyte-to-embryo transition. To unde
Externí odkaz:
https://doaj.org/article/98c8ffd77d664743a968903775a146ad
Autor:
Dimos Gaidatzis, Lukas Burger, Rabih Murr, Anita Lerch, Sophie Dessus-Babus, Dirk Schübeler, Michael B Stadler
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004143 (2014)
For the most part metazoan genomes are highly methylated and harbor only small regions with low or absent methylation. In contrast, partially methylated domains (PMDs), recently discovered in a variety of cell lines and tissues, do not fit this parad
Externí odkaz:
https://doaj.org/article/0f2046972cf84a5babcedf1731f6616c
Publikováno v:
Basic and Clinical Andrology, Vol 33, Iss 1, Pp 1-10 (2023)
Abstract Background Cryptorchid boys with defective mini-puberty and impaired differentiation of Ad spermatogonia (high infertility risk) have altered expression of several genes encoding histone methyltransferases compared to patients with intact di
Externí odkaz:
https://doaj.org/article/91295b31d63845eba3ba385f0a6befae
Autor:
Florian Lienert, Fabio Mohn, Vijay K Tiwari, Tuncay Baubec, Tim C Roloff, Dimos Gaidatzis, Michael B Stadler, Dirk Schübeler
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002090 (2011)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional p
Externí odkaz:
https://doaj.org/article/edf8fc02c7a84692b1783486f21c2db6