Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Michael B Sherman"'
Autor:
Jing Jin, Michael B Sherman, Daniel Chafets, Nuntana Dinglasan, Kai Lu, Tzong-Hae Lee, Lars-Anders Carlson, Marcus O Muench, Graham Simmons
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006693 (2018)
BACKGROUND:Chikungunya virus (CHIKV) is the most common alphavirus infecting humans worldwide, causing acute and chronically debilitating arthralgia at a great economic expense. METHODOLOGY/PRINCIPAL FINDINGS:To facilitate our study of CHIKV, we gene
Externí odkaz:
https://doaj.org/article/a2c9ded61f2a4fa1a4fbaed72ca3e21e
Autor:
Wenshuo Zhou, Michael Woodson, Biswas Neupane, Fengwei Bai, Michael B Sherman, Kyung H Choi, Girish Neelakanta, Hameeda Sultana
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006764 (2018)
Molecular determinants and mechanisms of arthropod-borne flavivirus transmission to the vertebrate host are poorly understood. In this study, we show for the first time that a cell line from medically important arthropods, such as ticks, secretes ext
Externí odkaz:
https://doaj.org/article/e38ce0540a6b42aeb5f460528cb3c817
Autor:
Annette E. LaBauve, Edwin A. Saada, Iris K. A. Jones, Richard Mosesso, Achraf Noureddine, Jessica Techel, Andrew Gomez, Nicole Collette, Michael B. Sherman, Rita E. Serda, Kimberly S. Butler, C. Jeffery Brinker, Joseph S. Schoeniger, Darryl Sasaki, Oscar A. Negrete
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Emerging and re-emerging viral pathogens present a unique challenge for anti-viral therapeutic development. Anti-viral approaches with high flexibility and rapid production times are essential for combating these high-pandemic risk viruses.
Externí odkaz:
https://doaj.org/article/64420571e4d74ee3884a72d980b6c8ad
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 307-326 (2019)
ABSTRACTThe harmful effects of ZIKA virus (ZIKV) infection are reflected by severe neurological manifestations such as microcephaly in neonates and other complications associated with Guillain-Barré syndrome in adults. The transmission dynamics of Z
Externí odkaz:
https://doaj.org/article/7fe57c9a89df48c2b87221addb0b4025
Publikováno v:
Nature Structural & Molecular Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d878eaf4937cce483ffcfd17027ef41
https://doi.org/10.1038/s41594-023-00980-2
https://doi.org/10.1038/s41594-023-00980-2
Autor:
Jing Jin, Nathan M. Liss, Dong-Hua Chen, Maofu Liao, Julie M. Fox, Raeann M. Shimak, Rachel H. Fong, Daniel Chafets, Sonia Bakkour, Sheila Keating, Marina E. Fomin, Marcus O. Muench, Michael B. Sherman, Benjamin J. Doranz, Michael S. Diamond, Graham Simmons
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2553-2564 (2015)
We evaluated the mechanism by which neutralizing human monoclonal antibodies inhibit chikungunya virus (CHIKV) infection. Potently neutralizing antibodies (NAbs) blocked infection at multiple steps of the virus life cycle, including entry and release
Externí odkaz:
https://doaj.org/article/73ebf265434a4ebbbb248581331d2655
Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Publikováno v:
Nature communications. 13(1)
During translation initiation, initiation factor 2 (IF2) holds initiator transfer RNA (fMet-tRNAifMet) in a specific orientation in the peptidyl (P) site of the ribosome. Upon subunit joining IF2 hydrolyzes GTP and, concomitant with inorganic phospha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946b55a187687224100b4d4e56fb0342
https://pubmed.ncbi.nlm.nih.gov/35697706
https://pubmed.ncbi.nlm.nih.gov/35697706
Autor:
Hong Q. Smith, Christiane E. Wobus, B. Montgomery Pettitt, Alexis N. Williams, Thomas J. Smith, Michael B. Sherman, Stefan Taube
Publikováno v:
J Virol
Human norovirus is the leading cause of gastroenteritis worldwide, with no approved vaccine or antiviral treatment to mitigate infection. These plus-strand RNA viruses have T = 3 icosahedral protein capsids with 90 pronounced protruding (P) domain di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15749a6426a114dc97d65d03394a0219
https://doi.org/10.1128/jvi.01471-21
https://doi.org/10.1128/jvi.01471-21
Autor:
Thomas J. Smith, Christiane E. Wobus, Alexis N. Williams, Hong Q. Smith, B. Montgomery Pettitt, Michael B. Sherman
Publikováno v:
Viruses
Viruses, Vol 13, Iss 2162, p 2162 (2021)
Viruses, Vol 13, Iss 2162, p 2162 (2021)
Noroviruses are responsible for almost a fifth of all cases of gastroenteritis worldwide. The calicivirus capsid is composed of 180 copies of VP1 with a molecular weight of ~58 kDa. This coat protein is divided into the N-terminus (N), the shell (S)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0528cc040c1729fb7005914a16879c73
http://europepmc.org/articles/PMC8621758
http://europepmc.org/articles/PMC8621758
Autor:
Sima Mafimoghaddam, Yuechuan Xu, Michael B. Sherman, Elena V. Orlova, Prashant Karki, Mehmet A. Orman, Peter G. Vekilov
Publikováno v:
Journal of Biological Chemistry. 298:102662
Fibrillization of the protein amyloid β is assumed to trigger Alzheimer's pathology. Approaches that target amyloid plaques, however, have garnered limited clinical success, and their failures may relate to the scarce understanding of the impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3abeeb504e1529edbf2b3516612194d
https://doi.org/10.1016/j.jbc.2022.102662
https://doi.org/10.1016/j.jbc.2022.102662