Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michael B Oldstone"'
Autor:
Margery G Smelkinson, Annabel Guichard, John R Teijaro, Meghana Malur, Maria Eugenia Loureiro, Prashant Jain, Sundar Ganesan, Elina I Zúñiga, Robert M Krug, Michael B Oldstone, Ethan Bier
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006588 (2017)
The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions. We report here on a new role for NS1 in modifying cell-cell signaling via the Hedgehog (Hh) pathway. Genetic epi
Externí odkaz:
https://doaj.org/article/8296206c2f914e29bb8799c937494a0b
Autor:
Cyrus Bett, Tim D Kurt, Melanie Lucero, Margarita Trejo, Annemieke J Rozemuller, Qingzhong Kong, K Peter R Nilsson, Eliezer Masliah, Michael B Oldstone, Christina J Sigurdson
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003280 (2013)
Infectious prions cause diverse clinical signs and form an extraordinary range of structures, from amorphous aggregates to fibrils. How the conformation of a prion dictates the disease phenotype remains unclear. Mice expressing GPI-anchorless or GPI-
Externí odkaz:
https://doaj.org/article/26526db1ef1344248a306b62cee33ac9
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002915 (2012)
Plasmacytoid dendritic cells (pDCs) are the major producers of type I IFN in response to viral infection and have been shown to direct both innate and adaptive immune responses in vitro. However, in vivo evidence for their role in viral infection is
Externí odkaz:
https://doaj.org/article/b572b0d142c942798b5146414ebbf07c
Autor:
Jaroslav Zak, Isaraphorn Pratumchai, Brett S. Marro, Kristi L. Marquardt, Michael B. Oldstone, Judith A. Varner, Veronika Bachanova, John R. Teijaro
Publikováno v:
Cancer Research. 83:5743-5743
Background: Checkpoint inhibitors have achieved a wide adoption for treatment of advanced cancer, but the majority of patients fail to respond. Among the underlying causes are redundant mechanisms driving cytotoxic lymphocyte dysfunction. Motivated b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c58daacab096b99f45bd3e7b9795c4ba
https://doi.org/10.1158/1538-7445.am2023-5743
https://doi.org/10.1158/1538-7445.am2023-5743
Autor:
Brian Martin Sullivan, Saori Sakabe, Jessica N Hartnett, Nhi Nho, Augustine Goba, Mambu Momoh, John Demby Sandi, Lansana Kanneh, Beatrice Cubitt, Selma D Garcia, Brian C Ware, Dylan Kotliar, Refugio Robles-Sikisaka, Karthik Gangavarapu, Juan Carlos de la Torre, Pardis C Sabeti, Kristian G Andersen, Robert F Garry, Donald S Grant, John S Schieffelin, Michael B Oldstone
Publikováno v:
The Journal of Immunology. 204:140.17-140.17
Many factors contribute to the selection of epitope-specific T cells. Often, candidate epitopes are generated through in silico prediction of various biological processes, mainly peptide generation and MHC binding, that are then tested in relevant bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be68eeb53b6906a23c2f940b60e3007e
https://doi.org/10.4049/jimmunol.204.supp.140.17
https://doi.org/10.4049/jimmunol.204.supp.140.17
Autor:
Brian Martin Sullivan, Saori Sakabe, Jessica Hartnett, Augustine Goba, Mambu Momoh, John Demby Sandi, John S. Schieffelin, Juan Carlos de la Torre, Donald S. Grant, Robert F. Garry, Michael B. Oldstone
Publikováno v:
The Journal of Immunology. 200:126.10-126.10
Primary infection with Ebola virus protects against subsequent challenge, thus an optimal vaccine should generate immune responses similar to those found in disease survivors. To this end, we characterized CD8 and CD4 T cell responses in Ebola surviv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43c01ebba6d2033bcdfa01406b217dbc
https://doi.org/10.4049/jimmunol.200.supp.126.10
https://doi.org/10.4049/jimmunol.200.supp.126.10
Publikováno v:
The Journal of Immunology. 200:126.22-126.22
Lassa fever (LF) is an acute disease characterized by enhanced vascular permeability resulting from infection with Lassa virus (LV), a non-lytic, Old World arenavirus. Animal models of arenavirus-induced vascular damage suggest that cytotoxic CD8+ T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::767efbe89a1456acadfa0b4758da1f2d
https://doi.org/10.4049/jimmunol.200.supp.126.22
https://doi.org/10.4049/jimmunol.200.supp.126.22
Autor:
Michael B. Oldstone
AIDS is caused by the human immunodeficiency virus (HIV) and constitutes a major health hazard to military and civilian populations. Our goal with this contract is to understand pathogenesis and to obtain a rational strategy for developing a vaccine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46340caa5cd17d63e62fa2445e2f7259
https://doi.org/10.21236/ada246936
https://doi.org/10.21236/ada246936
Autor:
Michael B. Oldstone
HIV (Human Immunodeficiency Virus) causes a persistent infection that results in AIDS, (Acquired Immune Deficiency Syndrome) a major health hazard to military and civilian populations. We have and continue to design and synthesize a variety of amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c888847c2dee6c78ba6274483ddbdf
https://doi.org/10.21236/ada232068
https://doi.org/10.21236/ada232068
Publikováno v:
The Journal of Immunology. 178:S61-S61
By definition persistent viral infections are accompanied by immune evasion, and most notably the failure to sustain robust T cell responses, responses that are essential to control of these infections. Identifying and understanding the immunoregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bf9c719c7585b04082c4f39fd04ed65
https://doi.org/10.4049/jimmunol.178.supp.46.3
https://doi.org/10.4049/jimmunol.178.supp.46.3