Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael B Doud"'
Autor:
Michael B. Doud, Animesh Gupta, Victor Li, Sarah J. Medina, Caesar A. De La Fuente, Justin R. Meyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract A major challenge in evolutionary biology is explaining how populations navigate rugged fitness landscapes without getting trapped on local optima. One idea illustrated by adaptive dynamics theory is that as populations adapt, their newly en
Externí odkaz:
https://doaj.org/article/f05ce5ec0d4d47bea8fccdb8e6850b5b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Influenza A virus can escape antibodies, but it is unclear how the ease of escape depends on the epitope targeted by an antibody. Here, the authors show that neutralization breadth is an imperfect indicator of the ease of viral escape by single mutat
Externí odkaz:
https://doaj.org/article/876257bdebd1481d98820158c8928e1b
Autor:
Angela M Phillips, Michael B Doud, Luna O Gonzalez, Vincent L Butty, Yu-Shan Lin, Jesse D Bloom, Matthew D Shoulders
Publikováno v:
eLife, Vol 7 (2018)
We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the
Externí odkaz:
https://doaj.org/article/bde65080ca6046dca52b4266f86786eb
Publikováno v:
PeerJ, Vol 5, p e3657 (2017)
It has recently become possible to experimentally measure the effects of all amino-acid point mutations to proteins using deep mutational scanning. These experimental measurements can inform site-specific phylogenetic substitution models of gene evol
Externí odkaz:
https://doaj.org/article/5bcdaa8ba5e64fc8abc1ab6350f1143b
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006288 (2017)
The innate-immune restriction factor MxA inhibits influenza replication by targeting the viral nucleoprotein (NP). Human influenza virus is more resistant than avian influenza virus to inhibition by human MxA, and prior work has compared human and av
Externí odkaz:
https://doaj.org/article/1ca1d5f6cd6e453ab63832fb53cfdf83
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006271 (2017)
Identifying viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution. We describe a high-throughput approach to quantify the selection that monoclonal antibodies exert on all s
Externí odkaz:
https://doaj.org/article/e6ff75ab62b2430ab1d93bff33dab506
Autor:
Michael B. Doud, Jesse D. Bloom
Publikováno v:
Viruses, Vol 8, Iss 6, p 155 (2016)
Influenza genes evolve mostly via point mutations, and so knowing the effect of every amino-acid mutation provides information about evolutionary paths available to the virus. We and others have combined high-throughput mutagenesis with deep sequenci
Externí odkaz:
https://doaj.org/article/23d76d6f332b4aa08cd228040dc9dca3
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so. Here, we ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d599ce77fb061b8fbccc21e6f0a096
https://doaj.org/article/876257bdebd1481d98820158c8928e1b
https://doaj.org/article/876257bdebd1481d98820158c8928e1b
Autor:
Michael B. Doud, Luna O Gonzalez, Yu-Shan Lin, Vincent L. Butty, Angela M Phillips, Matthew D. Shoulders, Jesse D. Bloom
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c895f7d2fbf77f03779f4e5b4a4332
http://europepmc.org/articles/PMC6172027
http://europepmc.org/articles/PMC6172027
