Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Michael B, Stout"'
Autor:
Jessica D. Hense, Driele N. Garcia, Bianka M. Zanini, Mariana M. Barreto, Giulia C. Perreira, José V. V. Isola, Camila de Brito, Michal Fornalik, Samim A. Mondal, Bianca M. Ávila, Thais L. Oliveira, Heather C. Rice, Charles I. Lacy, Rodrigo A. Vaucher, Jeffrey B. Mason, Michal M. Masternak, Michael B. Stout, Augusto Schneider
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effectiveness of senolytic drugs in reducing liver damage in mice with MASLD is not clear. Additionally, M
Externí odkaz:
https://doaj.org/article/326ef71c5c2c449693e78d894c2773a5
Autor:
Samim Ali Mondal, Shivani N. Mann, Carl van der Linden, Roshini Sathiaseelan, Maria Kamal, Snehasis Das, Matthew P. Bubak, Sreemathi Logan, Benjamin F. Miller, Michael B. Stout
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Metabolic dysfunction underlies several chronic diseases. Dietary interventions can reverse metabolic declines and slow aging but remaining compliant is difficult. 17α-estradiol (17α-E2) treatment improves metabolic parameters and slows ag
Externí odkaz:
https://doaj.org/article/969dd770bf374f9b85eea15768f7a62d
Autor:
Collyn M. Kellogg, Kevin Pham, Sunghwan Ko, Jillian E.J. Cox, Adeline H. Machalinski, Michael B. Stout, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108413- (2023)
Summary: Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (12 m.o.). While anecdotally reported as problematic, there are no publishe
Externí odkaz:
https://doaj.org/article/efa2f29c8faf4f80b3c9fffa0d593cbf
Autor:
Maria F. Mendez Garcia, Satoshi Matsuzaki, Albert Batushansky, Ryan Newhardt, Caroline Kinter, Yan Jin, Shivani N. Mann, Michael B. Stout, Haiwei Gu, Ying Ann Chiao, Michael Kinter, Kenneth M. Humphries
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107131- (2023)
Summary: A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production contributes to mitochondrial dysfunction and cardiomyopa
Externí odkaz:
https://doaj.org/article/ffdebaa794634e58a940833770287078
Autor:
Noah S Rozich, Samara E Lewis, Sixia Chen, Kenneth E Stewart, Michael B Stout, William C Dooley, Laura E Fischer, Katherine T Morris
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250726 (2021)
BackgroundWe hypothesize that women undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis from appendiceal cancer will have a survival advantage compared to men.MethodsThe National
Externí odkaz:
https://doaj.org/article/298e0e7bd8374e76924b1491e36d4003
Autor:
Kavitha Kurup, Shivani N Mann, Jordan Jackson, Stephanie Matyi, Michelle Ranjo-Bishop, Willard M Freeman, Michael B Stout, Arlan Richardson, Archana Unnikrishnan
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0237199 (2021)
Nutritional manipulations early in life have been shown to influence growth rate and elicit long lasting effects which in turn has been found to impact lifespan. Therefore, we studied the long-term effects of pre-weaning dietary restriction implement
Externí odkaz:
https://doaj.org/article/280e20be37f448c89f16b203045c092e
Autor:
Shivani N Mann, Niran Hadad, Molly Nelson Holte, Alicia R Rothman, Roshini Sathiaseelan, Samim Ali Mondal, Martin-Paul Agbaga, Archana Unnikrishnan, Malayannan Subramaniam, John Hawse, Derek M Huffman, Willard M Freeman, Michael B Stout
Publikováno v:
eLife, Vol 9 (2020)
Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves me
Externí odkaz:
https://doaj.org/article/1b1546f66bc7437c80062d0bfab7f142
Autor:
Roshini Sathiaseelan, Bumsoo Ahn, Michael B Stout, Sreemathi Logan, Jonathan Wanagat, Hoang Van M Nguyen, Norman G Hord, Amy R Vandiver, Ramasamy Selvarani, Rojina Ranjit, Hannah Yarbrough, Anthony Masingale, Benjamin F Miller, Roman F Wolf, Steven N Austad, Arlan Richardson
Publikováno v:
The Journals of Gerontology: Series A. 78:771-779
We generated a genetically heterogenous rat model by a 4-way cross strategy using 4 inbred strains (Brown Norway [BN], Fischer 344 [F344], Lewis [LEW], and Wistar Kyoto [KY]) to provide investigators with a highly genetically diverse rat model from c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d14d314dbf4c37472b4b446932ebdc9
https://doi.org/10.1093/gerona/glad056
https://doi.org/10.1093/gerona/glad056
Autor:
Driele N. Garcia, Jéssica D. Hense, Bianka M. Zanini, José V. V. Isola, Jorgea Pradiee, Juliane B. Prosczek, Joao A. Alvarado-Rincón, Rafael G. Mondadori, Jeffrey B. Mason, Miguel A. Brieño-Enríquez, Carlos C. Barros, Michael B. Stout, Michal M. Masternak, Augusto Schneider
Publikováno v:
Physiology International.
Cellular senescence is a defense mechanism to arrest proliferation of damaged cells. The number of senescent cells increases with age in different tissues and contributes to the development of age-related diseases. Old mice treated with senolytics dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ab4ad7dd0b25a9f514218679f3d6556
https://doi.org/10.1556/2060.2023.00192
https://doi.org/10.1556/2060.2023.00192
Autor:
José V. V. Isola, Sarah R. Ocañas, Chase R. Hubbart, Sunghwan Ko, Samim Ali Mondal, Jessica D. Hense, Augusto Schneider, Susan Kovats, Willard M. Freeman, Michael B. Stout
Publikováno v:
bioRxiv
Ovarian aging leads to diminished fertility, dysregulated endocrine signaling, and increased chronic disease burden. These effects begin to emerge long before follicular exhaustion. Around 35 years old, women experience a sharp decline in fertility,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7da29af6dbf6f4593fc34414979e723
https://doi.org/10.1101/2023.04.29.538828
https://doi.org/10.1101/2023.04.29.538828
