Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Michael B, O'Connor"'
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0305696 (2024)
In Drosophila coordinated proliferation of two neural stem cells, neuroblasts (NB) and neuroepithelial (NE) cells, is pivotal for proper larval brain growth that ultimately determines the final size and performance of an adult brain. The larval brain
Externí odkaz:
https://doaj.org/article/b576fd81785f40f09d6fe7d7e8af800b
Autor:
Aidan J Peterson, Stephen J Murphy, Melinda G Mundt, MaryJane Shimell, Edward B Leof, Michael B O'Connor
Publikováno v:
PLoS Biology, Vol 20, Iss 5, p e3001660 (2022)
In polarized epithelial cells, receptor-ligand interactions can be restricted by different spatial distributions of the 2 interacting components, giving rise to an underappreciated layer of regulatory complexity. We explored whether such regulation o
Externí odkaz:
https://doaj.org/article/cc3cee1f4bca4e6cb80a132153bce699
Autor:
Maciej Maselko, Nathan Feltman, Ambuj Upadhyay, Amanda Hayward, Siba Das, Nathan Myslicki, Aidan J. Peterson, Michael B. O’Connor, Michael J. Smanski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Natural speciation can be driven by pre-zygotic and post-zygotic barriers. Here the authors use a dominant lethal transgene coupled to a recessive resistance allele to engineer species-like barriers in Drosophila.
Externí odkaz:
https://doaj.org/article/270db01c945544cf80596ef77ef97a8d
Autor:
Agapi Dimitriadou, Nasia Chatzianastasi, Panagiota I. Zacharaki, MaryJane O’Connor, Samuel L. Goldsmith, Michael B. O’Connor, Christos Consoulas, Stuart J. Newfeld
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 5, Pp 1697-1706 (2020)
The CORL family of CNS-specific proteins share a Smad-binding region with mammalian SnoN and c-Ski protooncogenes. In this family Drosophila CORL has two mouse and two human relatives. Roles for the mouse and human CORL proteins are largely unknown.
Externí odkaz:
https://doaj.org/article/c6b3a725dfec484a9ef361bf9fcff13a
Autor:
Samuel L Goldsmith, MaryJane Shimell, Petra Tauscher, Samantha M Daly, Osamu Shimmi, Michael B O’Connor, Stuart J Newfeld
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 4 (2022)
AbstractGenes on the long arm of the Drosophila melanogasterBloom syndrome helicaserecombination defective
Externí odkaz:
https://doaj.org/article/70077ddd1ab34674bbb50257a895457a
Autor:
Shu Yang, Xuefeng Wu, Euphrosyne I Daoutidou, Ya Zhang, MaryJane Shimell, Kun-Han Chuang, Aidan J Peterson, Michael B O'Connor, Xiaoyan Zheng
Publikováno v:
eLife, Vol 11 (2022)
Hedgehog (Hh) and Bone Morphogenetic Proteins (BMPs) pattern the developing Drosophila wing by functioning as short- and long-range morphogens, respectively. Here, we show that a previously unknown Hh-dependent mechanism fine-tunes the activity of BM
Externí odkaz:
https://doaj.org/article/5383f019d9724b6689d2cd6c1cae0d03
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Metabolism, growth, and development are intrinsically linked, and their coordination is dependent upon inter-organ communication mediated by anabolic, catabolic, and steroid hormones. In Drosophila melanogaster, the corpora cardiaca (CC) influences m
Externí odkaz:
https://doaj.org/article/de14b8579ff24f38b09b95659342312f
Autor:
Heidi Bretscher, Michael B. O’Connor
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Maintaining energy homeostasis is critical for ensuring proper growth and maximizing survival potential of all organisms. Here we review the role of somatic muscle in regulating energy homeostasis in insects. The muscle is not only a large consumer o
Externí odkaz:
https://doaj.org/article/711d9579e44341d38127d0f630de6a89
Publikováno v:
eLife, Vol 9 (2020)
Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by
Externí odkaz:
https://doaj.org/article/49a02b373917452e814ba36176baaeb0
Autor:
Helen M Deeks, Rebecca K Walters, Stephanie R Hare, Michael B O'Connor, Adrian J Mulholland, David R Glowacki
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0228461 (2020)
Simulating drug binding and unbinding is a challenge, as the rugged energy landscapes that separate bound and unbound states require extensive sampling that consumes significant computational resources. Here, we describe the use of interactive molecu
Externí odkaz:
https://doaj.org/article/aba2e856f8de4d2a823980ea9b1932d7