Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael B, Mumphrey"'
Autor:
Michael B. Mumphrey, Noshad Hosseini, Abhijit Parolia, Jie Geng, Weiping Zou, Malini Raghavan, Arul Chinnaiyan, Marcin Cieslik
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112965- (2023)
Summary: Disruption of antigen presentation via loss of major histocompatibility complex (MHC) expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy. Here, we develop the personalized genomic
Externí odkaz:
https://doaj.org/article/d0c6d870f1f846c894747d75024f6dd8
Autor:
Brandon B. Boland, Michael B. Mumphrey, Zheng Hao, R. Leigh Townsend, Benji Gill, Stephanie Oldham, Sarah Will, Christopher D. Morrison, Sangho Yu, Heike Münzberg, Christopher J. Rhodes, James L. Trevaskis, Hans-Rudolf Berthoud
Publikováno v:
Molecular Metabolism, Vol 25, Iss , Pp 64-72 (2019)
Objective: Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity and metabolic disease. A
Externí odkaz:
https://doaj.org/article/f00f453e8c54473090de2a31207bdf75
Autor:
Justine Faramia, Zheng Hao, Michael B. Mumphrey, R. Leigh Townsend, Stéphanie Miard, Anne-Marie Carreau, Mélanie Nadeau, Frédérique Frisch, Elena-Dana Baraboi, Thomas Grenier-Larouche, Christophe Noll, Meng Li, Laurent Biertho, Simon Marceau, Frédéric-Simon Hould, Stéfane Lebel, Christopher D. Morrison, Heike Münzberg, Denis Richard, André C. Carpentier, André Tchernof, Hans-Rudolf Berthoud, Frédéric Picard
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100248- (2021)
Summary: Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health. Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching hig
Externí odkaz:
https://doaj.org/article/317635759b854ab9b3c219568d105c04
Autor:
Christopher D. Morrison, Zheng Hao, Michael B. Mumphrey, R. Leigh Townsend, Heike Münzberg, Jianping Ye, Hans-Rudolf Berthoud
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 1006-1014 (2016)
Objective: The mechanisms by which bariatric surgeries so effectively and lastingly reduce body weight and normalize metabolic dysfunction are not well understood. Fibroblast growth fator-21 (FGF21) is a key regulator of metabolism and is currently c
Externí odkaz:
https://doaj.org/article/4e6fe274582049b480824ea4da9d1624
Autor:
Amanpreet Kaur, Avrokin Surnilla, Anita J. Zaitouna, Venkatesha Basrur, Michael B. Mumphrey, Irina Grigorova, Marcin Cieslik, Mary Carrington, Alexey I. Nesvizhskii, Malini Raghavan
Activation of CD8+T cells against pathogens and cancers involves the recognition of antigenic peptides bound to human leukocyte antigen (HLA) class-I proteins. Peptide binding to HLA class I proteins is coordinated by a multi-protein complex called t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a3ec88401d9090057345e28aee3b96a
https://doi.org/10.1101/2023.02.26.530125
https://doi.org/10.1101/2023.02.26.530125
Loss of HLA expression in tumor cells is a commonly observed phenotype that is known to be associated with T-cell evasion. Proteogenomic characterizations of the molecular mechanisms underpinning this loss of HLA expression are hindered by the polymo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52d9e2aab497903cb886ce55b41360d8
https://doi.org/10.1101/2023.01.29.526142
https://doi.org/10.1101/2023.01.29.526142
MotivationAccurate detection of copy number variation (CNV) and loss of heterozygosity (LOH) in the major histocompatibility complex (MHC) locus is of great significance to both clinicians and researchers since it has the potential to inform treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc79805bcda13c973f21aecdac188e2b
https://doi.org/10.1101/2023.01.29.526131
https://doi.org/10.1101/2023.01.29.526131
Autor:
Christopher J. Rhodes, R. Leigh Townsend, Sangho Yu, Hans-Rudolf Berthoud, James L. Trevaskis, Michael B. Mumphrey, Stephanie Oldham, Brandon B. Boland, Zheng Hao, Sarah Will, Heike Münzberg, Benji Gill, Christopher D. Morrison
Publikováno v:
Molecular Metabolism, Vol 25, Iss, Pp 64-72 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity and metabolic disease. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560ece653d077ad2f9e5615bfb2a03fd
http://www.sciencedirect.com/science/article/pii/S2212877819302339
http://www.sciencedirect.com/science/article/pii/S2212877819302339
Autor:
R. Leigh Townsend, Michael B. Mumphrey, Hans-Rudolf Berthoud, Zheng Hao, Presheet Patkar, Andrew Shin
Publikováno v:
International journal of obesity (2005)
Objectives: Dieting often fails because weight loss triggers strong counter-regulatory biological responses such as increased hunger and hypometabolism that are thought to be critically dependent on the master fuel sensor in the mediobasal hypothalam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e3d403210faef9837f3e0d4e22fee0
https://doi.org/10.1038/s41366-019-0328-x
https://doi.org/10.1038/s41366-019-0328-x
Autor:
Christopher J Lelliott, Andrea Ahnmark, Therese Admyre, Ingela Ahlstedt, Lorraine Irving, Feenagh Keyes, Laurel Patterson, Michael B Mumphrey, Mikael Bjursell, Tracy Gorman, Mohammad Bohlooly-Y, Andrew Buchanan, Paula Harrison, Tristan Vaughan, Hans-Rudolf Berthoud, Daniel Lindén
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112109 (2014)
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose c
Externí odkaz:
https://doaj.org/article/b7aa8b820e4f483cb303314c37c5602a