Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Michael B, Jordan"'
Autor:
Michael B. Jordan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Type I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere with viral replication. While type II IFN (IFN-γ) largely protects against intracellular bacteria
Externí odkaz:
https://doaj.org/article/3e1029cdb09b448fa6f5750e3251f9da
Autor:
Pooja Khandelwal, Vijaya Chaturvedi, Erika Owsley, Yvonne A. Efebera, Hannah Choe, Matthew Bostic, Prashanti Kumchala, Girish Rajgolikar, Parvathi Ranganathan, Ramiro Garzon, Kelly Lake, Bridget Litts, Alexandra Duell, Patrick Elder, Stella M. Davies, Adam Lane, Michael B. Jordan, Sumithra Vasu, Steven Devine, Rebecca A. Marsh
Publikováno v:
Transplantation Reports, Vol 7, Iss 3, Pp 100100- (2022)
Introduction: We conducted a prospective validation study at Cincinnati Children's Hospital Medical Center and Ohio State University Medical Center to test if absolute CD38 bright CD8+TEM cells > 30/µL would predict acute GVHD, similar to our pilot
Externí odkaz:
https://doaj.org/article/6ad48f022f3d4a8582460eb163004509
Autor:
Denny K. Gao, Nathan Salomonis, Maggie Henderlight, Christopher Woods, Kairavee Thakkar, Alexei A. Grom, Sherry Thornton, Michael B. Jordan, Kathryn A. Wikenheiser-Brokamp, Grant S. Schulert
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Macrophage activation syndrome (MAS) is a life-threatening cytokine storm complicating systemic juvenile idiopathic arthritis (SJIA) driven by IFN-γ. SJIA and MAS are also associated with an unexplained emerging inflammatory lung disease (SJIA-LD),
Externí odkaz:
https://doaj.org/article/47d1d93c929347e5ab460781fc2d3411
Autor:
Greg Davis, Allen J York, Willis Clark Bacon, Suh-Chin Lin, Monica Malone McNeal, Alexander E Yarawsky, Joseph J Maciag, Jeanette L C Miller, Kathryn C S Locker, Michelle Bailey, Rebecca Stone, Michael Hall, Judith Gonzalez, Alyssa Sproles, E Steve Woodle, Kristen Safier, Kristine A Justus, Paul Spearman, Russell E Ware, Jose A Cancelas, Michael B Jordan, Andrew B Herr, David A Hildeman, Jeffery D Molkentin
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254667 (2021)
The world is currently in a pandemic of COVID-19 (Coronavirus disease-2019) caused by a novel positive-sense, single-stranded RNA β-coronavirus referred to as SARS-CoV-2. Here we investigated rates of SARS-CoV-2 infection in the greater Cincinnati,
Externí odkaz:
https://doaj.org/article/567754193c2d4608b6803f79e3e2b6ff
Autor:
Alice Y. Chan, Jennifer W. Leiding, Xuerong Liu, Brent R. Logan, Lauri M. Burroughs, Eric J. Allenspach, Suzanne Skoda-Smith, Gulbu Uzel, Luigi D. Notarangelo, Mary Slatter, Andrew R. Gennery, Angela R. Smith, Sung-Yun Pai, Michael B. Jordan, Rebecca A. Marsh, Morton J. Cowan, Christopher C. Dvorak, John A. Craddock, Susan E. Prockop, Shanmuganathan Chandrakasan, Neena Kapoor, Rebecca H. Buckley, Suhag Parikh, Deepak Chellapandian, Benjamin R. Oshrine, Jeffrey J. Bednarski, Megan A. Cooper, Shalini Shenoy, Blachy J. Davila Saldana, Lisa R. Forbes, Caridad Martinez, Elie Haddad, David C. Shyr, Karin Chen, Kathleen E. Sullivan, Jennifer Heimall, Nicola Wright, Monica Bhatia, Geoffrey D. E. Cuvelier, Frederick D. Goldman, Isabelle Meyts, Holly K. Miller, Markus G. Seidel, Mark T. Vander Lugt, Rosa Bacchetta, Katja G. Weinacht, Jeffrey R. Andolina, Emi Caywood, Hey Chong, Maria Teresa de la Morena, Victor M. Aquino, Evan Shereck, Jolan E. Walter, Morna J. Dorsey, Christine M. Seroogy, Linda M. Griffith, Donald B. Kohn, Jennifer M. Puck, Michael A. Pulsipher, Troy R. Torgerson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Primary Immune Regulatory Disorders (PIRD) are an expanding group of diseases caused by gene defects in several different immune pathways, such as regulatory T cell function. Patients with PIRD develop clinical manifestations associated with diminish
Externí odkaz:
https://doaj.org/article/a25da82b983d4175a8a4ab79f5cbf956
Autor:
Andrew R. Patterson, Mehari Endale, Kristin Lampe, Halil I. Aksoylar, Aron Flagg, Jim R. Woodgett, David Hildeman, Michael B. Jordan, Harinder Singh, Zeynep Kucuk, Jack Bleesing, Kasper Hoebe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β act
Externí odkaz:
https://doaj.org/article/09487aa202ff4465abb8756803164dd9
Autor:
Anna Hayden, Molly Lin, Sujin Park, Morris Pudek, Marion Schneider, Michael B. Jordan, Andre Mattman, Luke Y.C. Chen
Publikováno v:
Blood Advances, Vol 1, Iss 26, Pp 2529-2534 (2017)
Abstract: Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults. We conducted a single-center retrospective study of
Externí odkaz:
https://doaj.org/article/f0a1c3366c91438ca120f9581c9d23c8
Autor:
Nazanin Navabi, Jordan Whitt, Shu-en Wu, Vivienne Woo, Jessica Moncivaiz, Michael B. Jordan, Bruce A. Vallance, Sing Sing Way, Theresa Alenghat
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1165-1175 (2017)
Mucosal tissues are constantly in direct contact with diverse beneficial and pathogenic microbes, highlighting the need for orchestrating complex microbial signals to sustain effective host defense. Here, we show an essential role for intestinal epit
Externí odkaz:
https://doaj.org/article/cf9c6531f7a7493785cf44c32e72b6ad
Autor:
Adi Zoref-Lorenz, Jun Murakami, Liron Hofstetter, Uri Abadi, Swaminathan P. Iyer, Shehab Fareed Mohamed, Abd El Haleem Natour, Shiri Weinstein, Joanne Yacobovich, Shai Izraeli, Sarah Nikiforow, Ronit Gurion, Inbar Cohen, Oren Pasvolsky, Pia Raanani, Arnon Nagler, Nancy Berliner, Naval Daver, Martin H. Ellis, Gaurav Goyal, Michael B Jordan
Publikováno v:
Blood. 140:8326-8328
Autor:
Josselyn E. Garcia-Perez, Ryan M. Baxter, Daniel S. Kong, Richard Tobin, Martin McCarter, John M. Routes, James Verbsky, Michael B. Jordan, Cullen M. Dutmer, Elena W. Y. Hsieh
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
CTLA-4 is essential for immune tolerance. Heterozygous CTLA4 mutations cause immune dysregulation evident in defective regulatory T cells with low levels of CTLA-4 expression. Biallelic mutations in LRBA also result in immune dysregulation with low l
Externí odkaz:
https://doaj.org/article/c80be548f8aa430a82d406e1f50aadde