Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Michael B, Dwinell"'
Autor:
Angela L. Zhou, Davin R. Jensen, Francis C. Peterson, Monica A. Thomas, Roman R. Schlimgen, Michael B. Dwinell, Brian C. Smith, Brian F. Volkman
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 163-169 (2023)
The mucosal chemokine CCL28 is a promising target for immunotherapy drug development due to its elevated expression level in epithelial cells and critical role in creating and maintaining an immunosuppressive tumor microenvironment. Using sulfotyrosi
Externí odkaz:
https://doaj.org/article/cda8960ad51a44dcad7771ca3279a769
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102437- (2023)
Summary: Triphenylphosphonium (TPP+) compounds like mito-metformin (MMe) target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. Here, we present a protocol for synthesizing TPP+ analogs with selectivity for mammalian
Externí odkaz:
https://doaj.org/article/497bda50d3b54c428bd4084a75c9748d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Surgery or radiation therapy is nearly universally applied for pediatric solid tumors. In many cases, in diverse tumor types, distant metastatic disease is present and evades surgery or radiation. The systemic host response to these local control mod
Externí odkaz:
https://doaj.org/article/fc60fa83cf054983a326dbbe52fc010d
Autor:
Mahmoud AbuEid, Robert F. Keyes, Donna McAllister, Francis Peterson, Ishaque Pulikkal Kadamberi, Daniel J. Sprague, Pradeep Chaluvally-Raghavan, Brian C. Smith, Michael B. Dwinell
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105670- (2022)
Summary: Triphenylphosphonium (TPP+) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date, studies have focused on modifying either the linker or the cargo of TPP+-conjugate
Externí odkaz:
https://doaj.org/article/99c2993a07b44cb29438e9d937acc2d1
Autor:
Deepak Parashar, Anjali Geethadevi, Donna McAllister, Johnathan Ebben, Francis C. Peterson, Davin R. Jensen, Erin Bishop, Sunila Pradeep, Brian F. Volkman, Michael B. Dwinell, Pradeep Chaluvally-Raghavan, Michael A. James
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-13 (2021)
Abstract Recurrence of therapy-resistant tumors is a principal problem in solid tumor oncology, particularly in ovarian cancer. Despite common complete responses to first line, platinum-based therapies, most women with ovarian cancer recur, and event
Externí odkaz:
https://doaj.org/article/c7efb85699a44039a124ea4253dbf709
Autor:
Emily P. Vonderhaar, Nicholas S. Barnekow, Donna McAllister, Laura McOlash, Mahmoud Abu Eid, Matthew J. Riese, Vera L. Tarakanova, Bryon D. Johnson, Michael B. Dwinell
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 41-58 (2021)
Background & Aims: Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor microenvironment renders patients resistant to emerging immune-targeted therapie
Externí odkaz:
https://doaj.org/article/040336860c1f40a1a33eef7faad56fe7
Autor:
Guillermo Urrutia, Thiago Milech de Assuncao, Angela J. Mathison, Ann Salmonson, Romica Kerketta, Atefeh Zeighami, Timothy J. Stodola, Volkan Adsay, Burcin Pehlivanoglu, Michael B. Dwinell, Michael T. Zimmermann, Juan L. Iovanna, Raul Urrutia, Gwen Lomberk
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, painful disease with a 5-year survival rate of only 9%. Recent evidence indicates that distinct epigenomic landscapes underlie PDAC progression, identifying the H3K9me pathway as important to
Externí odkaz:
https://doaj.org/article/27246750f4cb4ec1b8c2a0e0e807cec6
Autor:
Mahmoud AbuEid, Donna M. McAllister, Laura McOlash, Megan Cleland Harwig, Gang Cheng, Donovan Drouillard, Kathleen A. Boyle, Micael Hardy, Jacek Zielonka, Bryon D. Johnson, R. Blake Hill, Balaraman Kalyanaraman, Michael B. Dwinell
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102653- (2021)
Summary: Metabolic heterogeneity within the tumor microenvironment promotes cancer cell growth and immune suppression. We determined the impact of mitochondria-targeted complex I inhibitors (Mito-CI) in melanoma. Mito-CI decreased mitochondria comple
Externí odkaz:
https://doaj.org/article/3630e5359dc747fea35d724c0b59cc72
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C167-C182
Chemokines are chemotactic cytokines whose canonical functions govern movement of receptor-expressing cells along chemical gradients. Chemokines are a physiological system that is finely tuned by ligand and receptor expression, ligand or receptor oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fd89c1e6b013455641f10d1363c2262
https://doi.org/10.1152/ajpcell.00151.2022
https://doi.org/10.1152/ajpcell.00151.2022
Autor:
Gang Cheng, Micael Hardy, Jacek Zielonka, Katherine Weh, Monika Zielonka, Kathleen A. Boyle, Mahmoud Abu Eid, Donna McAllister, Brian Bennett, Laura A. Kresty, Michael B. Dwinell, Balaraman Kalyanaraman
Publikováno v:
Cancer Treatment and Research Communications, Vol 25, Iss , Pp 100210- (2020)
Introduction: Melanoma is an aggressive form of skin cancer for which there are no effective drugs for prolonged treatment. The existing kinase inhibitor antiglycolytic drugs (B-Raf serine/threonine kinase or BRAF inhibitors) are effective for a shor
Externí odkaz:
https://doaj.org/article/39fdb841981f481cb80f9c25c3e0961d