Výsledky vyhledávání - "Michael Anthony William Eaton"

Synthesis of Cholesteryl Polyamine Carbamates: pKa Studies and Condensation of Calf Thymus DNA

Autor: Richard J. K. Taylor, Ian S. Blagbrough, Michael Anthony William Eaton, Mark E. Earll, Andrew J. Geall

Publikováno v: Bioconjugate Chemistry. 11:314-326

Novel polyamine carbamates have been designed and prepared from cholesterol. Our synthesis uses an orthogonal protection strategy based upon trifluoroacetyl and Boc-protecting groups. These unsymmetrical polyamine carbamates have been prepared from s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7af0935d7ffaac0ad657798babe5c4
https://doi.org/10.1021/bc990115w

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ChemInform Abstract: The Synthesis of Novel Bifunctional Linker Molecules

Autor: A. T. Millican, John Mann, K. Millar, Rikki P. Alexander, Michael Anthony William Eaton, Susan Billington, Paula Quazi

Publikováno v: ChemInform. 22

We describe the synthesis of the novel bifunctional linker molecule 2-methyl, 2-(3-carboxypropyl)-cyclopent-4-en-1,3-dione and various related compounds. These compounds are highly thiol-specific.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::088431dc9c4ca48dc3a16d66cf2d8767
https://doi.org/10.1002/chin.199140110

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The synthesis of novel bifunctional linker molecules

Autor: John Mann, A. T. Millican, Paula Quazi, Susan Billington, Rikki P. Alexander, Michael Anthony William Eaton, K. Millar

Publikováno v: Tetrahedron. 47:5231-5236

We describe the synthesis of the novel bifunctional linker molecule 2-methyl, 2-(3-carboxypropyl)-cyclopent-4-en-1,3-dione and various related compounds. These compounds are highly thiol-specific.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::697dd9d3b686711863a9ec64c3f3be38
https://doi.org/10.1016/s0040-4020(01)87134-9

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The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates

Autor: Nigel Robert Arnold Beeley, C Walker, Andrew S. Craig, SK Rhind, A Turner, J.M. Sansom, Amanda M. Randall, Alice Harrison, Jonathan P. L. Cox, Kenneth Millar, David Parker, Michael Anthony William Eaton, L. Chaplin, R.A. Boyce, A Farnsworth, Karl J. Jankowski, Andrew T. Millican, D.S. Secher

Publikováno v: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 18:469-476

Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90 Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90 Y-ligand complexes. Levels of 90 Y in fem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d3b59e56d2e8ec1983582d40de2663
https://doi.org/10.1016/0883-2897(91)90107-v

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The First Fluorescence Test of Vesicle Membrane Permeability without Chromatography

Autor: James Turner, Michael Anthony William Eaton, Claus Endisch, Andrea Schulz, Jürgen-Hinrich Fuhrhop

Publikováno v: Langmuir. 15:3707-3709

Endosome-type vesicle membranes containing 50% cholesterol were prepared in the presence of 10-6 M of a β-tetrapyridiniumporphyrin. Strong fluorescence at 640 nm was observed. Addition of a slight excess (1.5 × 10-6 M) of copper(II) meso-tetrapheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bda40e95d6456bb6072417ca71abdd63
https://doi.org/10.1021/la981712u

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Towards tumour targeting with copper-radiolabelled macrocycle–antibody conjugates: synthesis, antibody linkage, and complexation behaviour

Autor: J. Richard Morphy, Alice Harrison, David Parker, Michael Anthony William Eaton, Andrew T. Millican, Carol Walker, Rikki P. Alexander, Ritu Kataky

Publikováno v: J. Chem. Soc., Perkin Trans. 2. :573-585

A set of four tetra-azamacrocyclic ligands bearing aminomethylphenyl substituents have been prepared and may be attached to a monoclonal antibody via an intermediate thiol-specific vinylpyridine linker molecule. The resultant conjugates may be effici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d088b517c15937e430af7aded278d5af
https://doi.org/10.1039/p29900000573

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The regiochemical distribution of positive charges along cholesterol polyamine carbamates plays significant roles in modulating DNA binding affinity and lipofection

Autor: Ian S. Blagbrough, Terry Baker, Michael Anthony William Eaton, Andrew J. Geall, Catherine Fiona Catterall

Publikováno v: FEBS letters. 459(3)

We have quantified the effects of the regiochemical distribution of positive charges along the polyamine moiety in lipopolyamines for DNA molecular recognition. High affinity binding leads to charge neutralisation, DNA condensation and ultimately to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892439b160aa53bb9728c9a9c5ed6593
https://pubmed.ncbi.nlm.nih.gov/10526161

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