Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Michael Allgäuer"'
Autor:
Seyer Safi, Maximilian Robert Gysan, Dorothea Weber, Rouven Behnisch, Thomas Muley, Michael Allgäuer, Hauke Winter, Hans Hoffmann, Martin Eichhorn
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Reports from case series suggest that operative outcomes are comparable amongst different age groups following surgery with curative intent for non-small cell lung cancer (NSCLC). The purpose of this study was to compare morbidity
Externí odkaz:
https://doaj.org/article/977a1c2356d14261aaa0dc48afbf32cf
Autor:
Michael Menzel, Martina Kirchner, Klaus Kluck, Markus Ball, Susanne Beck, Michael Allgäuer, Christin Assmann, Johannes Schnorbach, Anna‐Lena Volckmar, Timothy Kwang Yong Tay, Hannah Goldschmid, Daniel SW Tan, Michael Thomas, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger, Petros Christopoulos
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract This study analyzed whether extended molecular profiling can predict the development of epidermal growth factor receptor (EGFR) gene T790M mutation, which is the most frequent resistance alteration in non‐small cell lung cancer (NSCLC) aft
Externí odkaz:
https://doaj.org/article/592032d0cf624a62bd5f0cb57fe2198c
Autor:
Michael Menzel, Stephan Ossowski, Sebastian Kral, Patrick Metzger, Peter Horak, Ralf Marienfeld, Melanie Boerries, Steffen Wolter, Markus Ball, Olaf Neumann, Sorin Armeanu-Ebinger, Christopher Schroeder, Uta Matysiak, Hannah Goldschmid, Vincent Schipperges, Axel Fürstberger, Michael Allgäuer, Timo Eberhardt, Jakob Niewöhner, Andreas Blaumeiser, Carolin Ploeger, Tobias Bernd Haack, Timothy Kwang Yong Tay, Olga Kelemen, Thomas Pauli, Martina Kirchner, Klaus Kluck, Alexander Ott, Marcus Renner, Jakob Admard, Axel Gschwind, Silke Lassmann, Hans Kestler, Falko Fend, Anna Lena Illert, Martin Werner, Peter Möller, Thomas Theodor Werner Seufferlein, Nisar Malek, Peter Schirmacher, Stefan Fröhling, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract A growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmenta
Externí odkaz:
https://doaj.org/article/c80cfb96a9be48f6bbb8329e92275143
Autor:
Olaf Neumann, Ulrich Lehmann, Stephan Bartels, Nicole Pfarr, Thomas Albrecht, Katharina Ilm, Jens Christmann, Anna‐Lena Volckmar, Hannah Goldschmid, Martina Kirchner, Michael Allgäuer, Maria Walker, Hans Kreipe, Andrea Tannapfel, Wilko Weichert, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 100-107 (2023)
Abstract Intrahepatic cholangiocarcinoma harbours druggable genetic lesions including FGFR2 gene fusions. Reliable and accurate detection of these fusions is becoming a critical component of the molecular work‐up, but real‐world data on the perfo
Externí odkaz:
https://doaj.org/article/766fefd6743746f48f23bf3da053da40
Autor:
Lino Möhrmann, Maximilian Werner, Małgorzata Oleś, Andreas Mock, Sebastian Uhrig, Arne Jahn, Simon Kreutzfeldt, Martina Fröhlich, Barbara Hutter, Nagarajan Paramasivam, Daniela Richter, Katja Beck, Ulrike Winter, Katrin Pfütze, Christoph E. Heilig, Veronica Teleanu, Daniel B. Lipka, Marc Zapatka, Dorothea Hanf, Catrin List, Michael Allgäuer, Roland Penzel, Gina Rüter, Ivan Jelas, Rainer Hamacher, Johanna Falkenhorst, Sebastian Wagner, Christian H. Brandts, Melanie Boerries, Anna L. Illert, Klaus H. Metzeler, C. Benedikt Westphalen, Alexander Desuki, Thomas Kindler, Gunnar Folprecht, Wilko Weichert, Benedikt Brors, Albrecht Stenzinger, Evelin Schröck, Daniel Hübschmann, Peter Horak, Christoph Heining, Stefan Fröhling, Hanno Glimm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The identification of molecular biomarkers in cancer of unknown primary site (CUP) cases may enable the improvement of prognosis in these patients. Here, the authors integrate whole genome/exome, transcriptome and methylome data in 70 CUP patients, r
Externí odkaz:
https://doaj.org/article/3ed8a79da7504e68a4003ab3bffbb8af
Autor:
Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ourailidis, Michael Allgäuer, Michael Menzel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 4, Pp 371-382 (2022)
Abstract Homologous recombination deficiency (HRD) leads to DNA double‐strand breaks and can be exploited by the use of poly (ADP‐ribose) polymerase (PARP) inhibitors to induce synthetic lethality. Extending the original therapeutic concept, the
Externí odkaz:
https://doaj.org/article/ff3298d8c2e9487488e839624f250057
Autor:
Dennis Niebel, Paula Kranert, Mark Berneburg, Konstantin Drexler, Maria Isabel vonEichborn, Jan Braess, Michael Allgäuer, Sigrid Karrer
Publikováno v:
Skin Health and Disease, Vol 3, Iss 2, Pp n/a-n/a (2023)
Abstract Carcinoma erysipelatoides (CE) is a rare clinical manifestation of cutaneous metastasis, which mimics inflammatory conditions such as erysipelas. Depending on the site of the originating tumour, unusual manifestations involving different sit
Externí odkaz:
https://doaj.org/article/1c1fcc0a611e4e78a24c207b48959a62
Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage ResponseSummary
Autor:
Victoria Neumeyer, Anna Brutau-Abia, Michael Allgäuer, Nicole Pfarr, Wilko Weichert, Christina Falkeis-Veits, Elisabeth Kremmer, Michael Vieth, Markus Gerhard, Raquel Mejías-Luque
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1071-1094 (2021)
Background & Aims: RING finger protein 43 (RNF43) is a tumor suppressor that frequently is mutated in gastric tumors. The link between RNF43 and modulation of Wingless-related integration site (WNT) signaling has not been shown clearly in the stomach
Externí odkaz:
https://doaj.org/article/472f9999d5b54f16995372b20c368717
Autor:
Farastuk Bozorgmehr, Daniel Kazdal, Inn Chung, Martina Kirchner, Nikolaus Magios, Mark Kriegsmann, Michael Allgäuer, Laura V. Klotz, Thomas Muley, Rami A. El Shafie, Jürgen R. Fischer, Martin Faehling, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundMetastatic epidermal growth factor receptor-mutated (EGFR+) non-small-cell lung cancer (NSCLC) can present de novo or following previous nonmetastatic disease (secondary). Potential differences between these two patient subsets are unclear
Externí odkaz:
https://doaj.org/article/51260c5b8fc9497c9800dfde3329757f
Autor:
Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Stefan Fröhling, Solange Peters, Barbara Seliger, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Immune checkpoint blockade (ICB) expands the therapeutic options for metastatic lung cancer nowadays representing a standard frontline strategy as monotherapy or combination therapy, as well as an option in oncogene-addicted NSCLC after exhaustion of
Externí odkaz:
https://doaj.org/article/8161f49b2e7d4570b7ef75ffd9167dba